Comment diagnostiquer une dysfonction de MAPK3 ?

Des tests génétiques et des analyses de signalisation cellulaire peuvent être utilisés.

Quels tests sont utilisés pour évaluer MAPK3 ?

Les tests de phosphorylation et les analyses protéomiques sont courants.

Y a-t-il des biomarqueurs associés à MAPK3 ?

Des niveaux anormaux de certaines protéines peuvent indiquer une dysfonction de MAPK3.

MAPK3 est-elle impliquée dans des maladies spécifiques ?

Oui, elle est liée à des cancers et des maladies inflammatoires.

Quels symptômes peuvent indiquer un problème avec MAPK3 ?

Des symptômes variés selon la maladie, comme la fatigue ou des douleurs chroniques.

Quels symptômes sont liés à une activation excessive de MAPK3 ?

Une activation excessive peut entraîner une inflammation et des douleurs.

MAPK3 affecte-t-elle le système immunitaire ?

Oui, elle joue un rôle dans la régulation de la réponse immunitaire.

Quels signes cliniques sont associés à MAPK3 ?

Des signes comme des éruptions cutanées ou des troubles métaboliques peuvent apparaître.

Y a-t-il des symptômes neurologiques liés à MAPK3 ?

Des troubles neurologiques peuvent survenir en cas de dysfonction de MAPK3.

Comment la MAPK3 influence-t-elle le stress cellulaire ?

Elle régule les réponses au stress, affectant la survie cellulaire et l'apoptose.

Comment prévenir les dysfonctionnements de MAPK3 ?

Un mode de vie sain, incluant une bonne nutrition et de l'exercice, est recommandé.

Y a-t-il des habitudes à éviter pour MAPK3 ?

Éviter le tabagisme et une alimentation riche en graisses saturées est conseillé.

Le stress peut-il affecter MAPK3 ?

Oui, le stress chronique peut perturber la signalisation de MAPK3.

Des exercices spécifiques aident-ils MAPK3 ?

Des exercices réguliers peuvent améliorer la régulation de MAPK3.

La gestion du poids influence-t-elle MAPK3 ?

Maintenir un poids santé peut aider à réguler l'activité de MAPK3.

Quels traitements ciblent MAPK3 ?

Des inhibiteurs spécifiques de MAPK3 sont en développement pour traiter certains cancers.

La thérapie génique peut-elle corriger MAPK3 ?

La thérapie génique est une approche potentielle pour corriger des mutations de MAPK3.

Quels médicaments affectent la voie MAPK3 ?

Des médicaments comme les inhibiteurs de MEK peuvent moduler l'activité de MAPK3.

Y a-t-il des traitements naturels pour MAPK3 ?

Certaines plantes médicinales peuvent influencer la signalisation de MAPK3.

Comment la nutrition influence-t-elle MAPK3 ?

Une alimentation riche en antioxydants peut moduler l'activité de MAPK3.

Quelles complications peuvent survenir avec une dysfonction de MAPK3 ?

Des complications comme le cancer, l'inflammation chronique et des troubles métaboliques peuvent survenir.

MAPK3 est-elle liée à des maladies auto-immunes ?

Oui, des anomalies dans MAPK3 peuvent contribuer à des maladies auto-immunes.

Comment MAPK3 affecte-t-elle le cancer ?

Une activation aberrante de MAPK3 est souvent observée dans divers types de cancer.

Y a-t-il des risques cardiovasculaires liés à MAPK3 ?

Des études suggèrent un lien entre MAPK3 et des maladies cardiovasculaires.

MAPK3 peut-elle influencer le vieillissement ?

Des dysfonctionnements de MAPK3 sont associés à des processus de vieillissement prématuré.

Quels facteurs de risque sont associés à MAPK3 ?

Des facteurs comme l'obésité, le tabagisme et le stress sont des risques connus.

L'âge influence-t-il l'activité de MAPK3 ?

Oui, l'activité de MAPK3 peut diminuer avec l'âge, affectant la signalisation cellulaire.

Y a-t-il des prédispositions génétiques pour MAPK3 ?

Certaines mutations génétiques peuvent prédisposer à des dysfonctionnements de MAPK3.

Le mode de vie influence-t-il MAPK3 ?

Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent les risques.

Des infections peuvent-elles affecter MAPK3 ?

Certaines infections virales peuvent perturber la signalisation de MAPK3.

Mitogen-Activated Protein Kinase 3 - Informations médicales vérifiées

Unsupervised home spirometry

30 Sep 2023

DOI: 10.1183/16000617.0248-2022 PMID: 37673426

The number of patients completing unsupervised home spirometry has recently increased due to more widely available portable technology and the COVID-19 pandemic, despite a lack of solid evidence to su... We searched four databases to find studies that directly compared unsupervised home spirometry with supervised clinic spirometry using a quantitative comparison (... 3607 records were identified and screened, with 155 full texts assessed for eligibility. We included 28 studies that quantitatively compared spirometry measurements, 17 of which reported a Bland-Altma... Analysis under the conditions of the included studies indicated that unsupervised spirometry is not interchangeable with supervised spirometry for individual patients owing to variability and underest...

Humans COVID-19 Forced Expiratory Volume Pandemics Respiratory Tract Diseases +1 autres

[Repeatability of spirometrys expiratory flows].

08 Jan 2024

DOI: 10.5281/zenodo.10278119 PMID: 39110813

The quality of the spirometry is estimated with criteria of acceptability and repeatability. The repeatability criteria accepted by consensus is < 0.150 L.... To know the repeatability in quality A spirometry.... Analytical cross-sectional design. The demographic variables and the 3 best spirometry curves with normal, suggestive of restriction and bronchial obstruction profiles were obtained from consecutive s... 630 curves from 210 subjects were accepted. Group age 60 ± 15 years. Female predominance 113 (53.8%), occupation: domestic services 61 (29%), and diagnosed with chronic obstructive pulmonary disease: ... The repeatability obtained in spirometry with quality A validates the use of the repeatability criterion of 0.150 L....

Humans Cross-Sectional Studies Spirometry Female Male +9 autres

How to interpret spirometry in a child with suspected asthma.

12 2022

DOI: 10.1136/archdischild-2022-324308 PMID: 36008112

Asthma is one of the most common chronic disorders of childhood. The typical symptoms are a result of reversible airway obstruction. There is no 'gold-standard' test to diagnose asthma, but the most c...

Child Humans Forced Expiratory Volume Spirometry Bronchodilator Agents +2 autres

Comparison of New Spirometry Measures to Diagnose COPD.

Mar 2023

DOI: 10.4187/respcare.10191 PMID: 36414276

COPD is diagnosed by using FEV... We conducted a cross-sectional diagnostic test study in 765 consecutive subjects referred for spirometry because of respiratory symptoms. We compared the reproducibility and accuracy of the proposed m... The subjects had a mean age of 65.8 y, 57% were women, and 35% had COPD. The test-retest intraclass correlation coefficient values were 0.89, 0.85, and 0.83 for FEV... The FEV...

Humans Female Aged Male Pulmonary Disease, Chronic Obstructive +5 autres

Airwave oscillometry and spirometry in children with asthma or wheeze.

06 2023

DOI: 10.1080/02770903.2022.2134795 PMID: 36218195

Lung function testing is used in diagnosing asthma and assessing asthma control. Spirometry is most commonly used, but younger children can find performing this test challenging. Non-volitional tests ... AOS was conducted alongside routine lung function testing. Resistance at 5 Hz (R5), the difference between the resistance at 5 and 20 Hz (R5-20) and the area under the reactance curve (AX) were assess... Lung function testing was performed in 47 children of whom 46 (98%) and 32 (68%) performed acceptable baseline oscillometry and spirometry, respectively (... Oscillometry is a useful adjunct to spirometry in assessing young asthmatic children's lung function. The degree of airway obstruction, however, might affect the comparability of the results of the tw...

Humans Child Child, Preschool Adolescent Asthma +4 autres

Normal spirometry prediction equations for the Iranian population.

12 Dec 2022

DOI: 10.1186/s12890-022-02273-8 PMID: 36510197

This study aimed to establish normative spirometric equations in a healthy population of Iranian children and adults, and compare these equations with those developed by the Caucasian Global Lung Init... Spirometric data from healthy Iranian aged 4-82 years sampled in 2019 were used to derive reference equations using the generalized additive model for location (mu), shape (lambda), and scale (sigma).... A total of 418 females and 204 males were included in the study. Applying the GLI standards for the Iranian population resulted from the Z scores of FEV... It is recommended that the values and equations generated from this study should be used by physicians and technicians in their routine practice for the diagnosis and assessment of pulmonary disorders...

Adult Child Male Female Humans +9 autres

Unsupervised home spirometry is not equivalent to supervised clinic spirometry in children and young people with cystic fibrosis: Results from the CLIMB-CF study.

10 2023

DOI: 10.1002/ppul.26602 PMID: 37503909

Handheld spirometry allows monitoring of lung function at home, of particular importance during the COVID-19 pandemic. Pediatric studies are unclear on whether values are interchangeable with traditio... Data from participants in the Clinical Monitoring and Biomarkers to stratify severity and predict outcomes in children with cystic fibrosisc (CLIMB-CF) Study aged ≥ 6 years who had paired (±1 day) cli... Sixty-seven participants (median [interquartile range] age 10.7 [7.6-13.9] years) provided home and clinic FEV... In children and adolescents, home spirometry using hand-held equipment cannot be used interchangeably with clinic spirometry. Home spirometry is moderately variable during clinical stability. New hand...

Adolescent Humans Child Cystic Fibrosis Pandemics +3 autres

Spirometry in laryngotracheal stenosis: a systematic review and meta-analysis.

Nov 2023

DOI: 10.1007/s00405-023-08159-7 PMID: 37522909

This study aimed to assess the changes in spirometry parameters or indices after relieving laryngotracheal stenosis (LTS) in adult patients.... A systematic review and meta-analysis of studies from PubMed, Scopus, Web of Science, Cochrane Library, and EBSCO databases was conducted for assessing changes in spirometry values after endoscopic ba... Ten studies including 330 patients overall met the inclusion criteria. Significant improvements were observed from preoperative to postoperative mean values of different spirometry parameters and indi... Spirometry is a valuable tool for assessing patients with LTS. PEF, EDI, and PIF were the most commonly reported spirometry parameters that significantly improved after airway stenosis was relieved....

Adult Humans Constriction, Pathologic Spirometry Tracheal Stenosis +3 autres

Spirometry and respiratory oscillometry: Feasibility and concordance in schoolchildren with asthma.

Jul 2023

DOI: 10.1002/ppul.26409 PMID: 37067397

The purpose of this study was to describe the feasibility of respiratory oscillometry (RO) in schoolchildren with asthma, and the concordance of its results with those of spirometry, to determine its ... RO and spirometry were performed in 154 children (6 to 14-year-old) with asthma, following strict quality criteria for the tests. Their feasibility (probability of valid test, time of execution, numbe... There were no differences in the probability of obtaining a valid RO or spirometry (83.1% vs. 81.8%, p = 0.868). RO required a lower number of maneuvers [mean (SD) 4.2 (1.8) versus 6.0 (1.6), p < 0.00... RO and spirometry are feasible in children with asthma. RO has some practical advantages, but the concordance of its results with spirometry is low....

Child Humans Adolescent Oscillometry Feasibility Studies +3 autres

Restrictive spirometry pattern among construction trade workers.

06 2023

DOI: 10.1002/ajim.23474 PMID: 36942569

Spirometry-based studies of occupational lung disease have mostly focused on obstructive or mixed obstructive/restrictive outcomes. We wanted to determine if restrictive spirometry pattern (RSP) is as... Study participants included 18,145 workers with demographic and smoking data and repeatable spirometry. The mortality analysis cohort included 15,445 workers with known vital status and cause of death... Prevalence of RSP was very high (28.6%). Mortality hazard ratios for RSP were 1.50 for all causes, 1.86 for cardiovascular diseases, 2.31 for respiratory diseases, and 1.66 for lung cancer. All constr... Construction trade workers are at significantly increased risk for RSP independent of obesity. Individuals with RSP are at increased risk for all-cause mortality as well as mortality attributable to r...

Humans Construction Industry Cardiovascular Diseases Spirometry Respiration Disorders +2 autres

Mitogen-Activated Protein Kinase 3 : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Auteurs principaux

Sources (536 au total)