questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Protéines membranaires
Glycoprotéines membranaires
Syndécanes
Syndécane-3
Syndécane-3 : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Syndécane-3
Tests génétiques
Biopsie
Immunohistochimie
Dosage sanguin
Syndécane-3
Marqueurs tumoraux
Cytokines
Symptômes
5
Dysfonction
Anomalies tissulaires
Cancer
Maladies inflammatoires
Anomalies cutanées
Syndécane-3
Prévention
5
Prévention
Mode de vie sain
Facteurs de risque
Inflammation chronique
Traitements
5
Thérapies ciblées
Anticorps monoclonaux
Effets secondaires
Réactions immunitaires
Traitements expérimentaux
Évaluation
Suivi
Réponse au traitement
Complications
5
Complications
Métastases tumorales
Complications cardiovasculaires
Syndécane-3
Complications neurologiques
Recherche
Gestion
Approche multidisciplinaire
Réversibilité
Traitement approprié
Facteurs de risque
5
Facteurs de risque
Antécédents familiaux
Obésité
Dysfonctionnements
Facteurs environnementaux
Polluants
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"@type": "Question",
"name": "Comment diagnostiquer une anomalie du syndécane-3 ?",
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"text": "Le diagnostic repose sur des tests génétiques et des analyses de tissus pour évaluer l'expression du syndécane-3."
}
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{
"@type": "Question",
"name": "Quels examens sont utilisés pour évaluer le syndécane-3 ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des biopsies et des analyses immunohistochimiques peuvent être réalisées pour évaluer le syndécane-3."
}
},
{
"@type": "Question",
"name": "Le dosage sanguin peut-il aider au diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de dosage sanguin standardisé pour le syndécane-3."
}
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{
"@type": "Question",
"name": "Quels marqueurs sont associés au syndécane-3 ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des marqueurs tumoraux et des cytokines peuvent être associés à l'expression du syndécane-3."
}
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{
"@type": "Question",
"name": "Le diagnostic est-il difficile à établir ?",
"position": 5,
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"@type": "Question",
"name": "Quels symptômes sont liés à une dysfonction du syndécane-3 ?",
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"@type": "Question",
"name": "Le syndécane-3 est-il lié à des maladies spécifiques ?",
"position": 7,
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"@type": "Question",
"name": "Peut-on observer des symptômes cutanés ?",
"position": 8,
"acceptedAnswer": {
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"text": "Des anomalies cutanées peuvent survenir en raison de l'implication du syndécane-3 dans la peau."
}
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{
"@type": "Question",
"name": "Y a-t-il des symptômes systémiques associés ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes systémiques comme la fatigue et la douleur peuvent être observés dans certains cas."
}
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"@type": "Question",
"name": "Les symptômes varient-ils d'un patient à l'autre ?",
"position": 10,
"acceptedAnswer": {
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"text": "Oui, les symptômes peuvent varier considérablement selon l'individu et la pathologie associée."
}
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{
"@type": "Question",
"name": "Peut-on prévenir les dysfonctionnements du syndécane-3 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention est difficile, mais un mode de vie sain peut réduire certains risques associés."
}
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{
"@type": "Question",
"name": "Y a-t-il des facteurs de risque connus ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des facteurs comme l'inflammation chronique et des prédispositions génétiques sont identifiés."
}
},
{
"@type": "Question",
"name": "Des dépistages réguliers sont-ils recommandés ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des dépistages peuvent être recommandés pour les personnes à risque élevé de maladies associées."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle le syndécane-3 ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut influencer positivement l'expression du syndécane-3."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur le syndécane-3 ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut affecter l'expression du syndécane-3 et contribuer à des maladies."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent le syndécane-3 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies ciblées et des anticorps monoclonaux peuvent être utilisés pour cibler le syndécane-3."
}
},
{
"@type": "Question",
"name": "Le traitement est-il efficace ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'efficacité du traitement dépend de la pathologie et de l'expression du syndécane-3."
}
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{
"@type": "Question",
"name": "Y a-t-il des effets secondaires des traitements ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent entraîner des effets secondaires comme des réactions immunitaires."
}
},
{
"@type": "Question",
"name": "Des traitements expérimentaux existent-ils ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des traitements expérimentaux sont en cours d'évaluation pour cibler le syndécane-3."
}
},
{
"@type": "Question",
"name": "Le suivi est-il nécessaire après traitement ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi régulier est essentiel pour évaluer la réponse au traitement et ajuster si nécessaire."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec le syndécane-3 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme des métastases tumorales et des troubles immunitaires peuvent survenir."
}
},
{
"@type": "Question",
"name": "Le syndécane-3 est-il lié à des complications cardiovasculaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des études suggèrent un lien entre le syndécane-3 et des complications cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Des complications neurologiques sont-elles possibles ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines recherches indiquent que des complications neurologiques peuvent être associées."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées au syndécane-3 ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion des complications nécessite une approche multidisciplinaire et un suivi régulier."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement approprié, d'autres non."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'âge, les antécédents familiaux et les maladies inflammatoires."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il les risques ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent les risques."
}
},
{
"@type": "Question",
"name": "Les infections jouent-elles un rôle ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections chroniques peuvent augmenter le risque de dysfonction du syndécane-3."
}
},
{
"@type": "Question",
"name": "Y a-t-il un lien avec l'obésité ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'obésité est un facteur de risque reconnu pour des dysfonctionnements associés au syndécane-3."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux sont-ils significatifs ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des polluants environnementaux peut influencer l'expression du syndécane-3."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 25/04/2025
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Department of Biochemistry, IIB, University of Liverpool, Liverpool, UK.
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA.
Publications dans "Syndécane-3" :
4 publications dans cette catégorie
Affiliations :
Department of Gynecology and Obstetrics, Münster University Hospital, Albert-Schweitzer-Campus 1, D11, 48149 Muenster, Germany.
Publications dans "Syndécane-3" :
4 publications dans cette catégorie
Affiliations :
Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Publications dans "Syndécane-3" :
3 publications dans cette catégorie
Affiliations :
Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Publications dans "Syndécane-3" :
3 publications dans cette catégorie
Affiliations :
Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Publications dans "Syndécane-3" :
3 publications dans cette catégorie
Affiliations :
Pharmacoidea Ltd., H-6726 Szeged, Hungary.
Publications dans "Syndécane-3" :
3 publications dans cette catégorie
Affiliations :
Pharmacoidea Ltd., H-6726 Szeged, Hungary.
Publications dans "Syndécane-3" :
3 publications dans cette catégorie
Affiliations :
Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.
Publications dans "Syndécane-3" :
3 publications dans cette catégorie
Affiliations :
Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.
Publications dans "Syndécane-3" :
3 publications dans cette catégorie
Affiliations :
Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.
K.G. Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway.
Publications dans "Syndécane-3" :
3 publications dans cette catégorie
Affiliations :
ICBMS, UMR 5246 CNRS - University Lyon 1, Univ Lyon, Villeurbanne, France.
Publications dans "Syndécane-3" :
3 publications dans cette catégorie
Affiliations :
Biotech Research & Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark.
Publications dans "Syndécane-3" :
3 publications dans cette catégorie
Affiliations :
Department of Gynecology and Obstetrics, Münster University Hospital, Munster, Germany.
Disciplina de Biologia Molecular, Departamento de Bioquímica, Universidade Federal de São Paulo, Sao Paulo, Brazil.
Publications dans "Syndécane-3" :
3 publications dans cette catégorie
Affiliations :
Disciplina de Biologia Molecular, Departamento de Bioquímica, Universidade Federal de São Paulo, Sao Paulo, Brazil.
Departamento de Ciências Biológicas, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Sao Paulo, Brazil.
Publications dans "Syndécane-3" :
2 publications dans cette catégorie
Affiliations :
Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Publications dans "Syndécane-3" :
2 publications dans cette catégorie
Affiliations :
Albert Szent-Györgyi Clinical Center, Department of Medicine, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary.
Publications dans "Syndécane-3" :
2 publications dans cette catégorie
Affiliations :
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA.
Publications dans "Syndécane-3" :
2 publications dans cette catégorie
Affiliations :
Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.
Bjørknes College, Oslo, Norway.
Publications dans "Syndécane-3" :
2 publications dans cette catégorie
Affiliations :
Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway.
K.G. Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway.
Publications dans "Syndécane-3" :
2 publications dans cette catégorie
Affiliations :
ICBMS, UMR 5246 CNRS - University Lyon 1, Univ Lyon, Villeurbanne, France.
Publications dans "Syndécane-3" :
The role of nimodipine and milrinone in the management of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) was studied using clinical and TCD (transcranial Doppler) param...
In this prospective observational study, patients with DCI after aneurysmal SAH presenting between November 2020 and June 2021 who were treated by either intra-arterial nimodipine (IAN) or intravenous...
Thirty-four patients fulfilled the inclusion criteria (IVM, 13/34 [38%]; IAN, 21/34 [62%]); patients in the IVM group (vs. IAN group) had poorer median Glasgow Coma Scale score (12 vs. 13), poorer mot...
In this single-center small study, patients in the IAN group had significantly less mortality compared with the IVM group in the management of DCI after aneurysmal SAH....
The aim of this study was to assess the safety and efficacy of long-term milrinone therapy in children with acute decompensated heart failure due to dilated cardiomyopathy (DCM)....
A single-centre retrospective study of all children ≤18 years with acute decompensated heart failure and DCM who received continuous long-term (≥7 consecutive days) intravenous milrinone between Janua...
The 47 patients had a median age of 3.3 months [interquartile range (IQR) 1.0-18.1], weight of 5.7 kg [IQR 4.3-10.1] and fractional shortening of 11.9% [±4.7]. Idiopathic DCM (n = 19) and myocarditis ...
Long-term intravenous milrinone is safe and effective in paediatric acute decompensated DCM. Combined with conventional heart failure therapies, it can act as a bridge to recovery and thereby potentia...
Mean arterial pressure to mean pulmonary arterial pressure ratio (mAP/mPAP) has been identified as a strong predictor of perioperative complications in cardiac surgery. We therefore investigated the p...
Knowledge on the spectral properties of the tautomers of milrinone (MLR) in solvents and solid-state, as well as under light conditions is of critical importance from both theoretical and practical po...
The symptom profile of children dying from cardiac disease, especially heart failure, differs from those with cancer and other non-cardiac conditions. Treatment with vasoactive infusions at home may b...
We report our experience using outpatient milrinone in children receiving hospice care for end-stage heart failure....
Retrospective review of a contemporary cohort of all patients at Lucile Packard Children's Hospital, Stanford who were discharged on intravenous milrinone and hospice care between 2008 and 2021. Clini...
Among 8 patients, median duration of home milrinone infusion was 191 (33, 572) days with the longest support duration 1,054 days. All (100%) patients were also receiving diuretics at the time of death...
We used milrinone with oral diuretics effectively for symptom control in children with heart failure on palliative care. Our experience was that this combination can be used safely in the outpatient s...
Both milrinone and levosimendan have been used in patients undergoing surgical closure of ventricular septal defects (VSD) with pulmonary artery hypertension (PAH); however, the evidence base for thei...
A prospective, randomized, controlled trial....
At a tertiary-care center....
Children between 1 month and 12 years presenting with VSD and PAH between 2018 and 2020....
A total of 132 patients were randomized into the following 2 groups: Group L (levosimendan group) and Group M (milrinone group)....
In addition to conventional hemodynamic parameters, the authors also included a myocardial performance index assessment to compare the groups. The levosimendan group had significantly lower mean arter...
In patients undergoing surgical repair for VSD with PAH, levosimendan does not confer any additional benefit compared to milrinone. Both milrinone and levosimendan appear to be safe in this cohort....
Pulmonary hypertension (PH) and right ventricular (RV) dysfunction are major complications in cardiac surgery. This study aimed to evaluate the change in RV pressure waveform in patients receiving a c...
A prospective single-centre cohort study of adult patients undergoing cardiac surgery administered iE&iM through an ultrasonic mesh nebulizer. RV pressure waveform monitoring was obtained by continuou...
The final analysis included 26 patients receiving iE&iM. There was a significant drop in mean PA pressure (MPAP) (-4.8 ± 8.7, P = 0.010), systolic PA pressure (SPAP) (-8.2 ± 12.8, P = 0.003), RV end-d...
Coadministration of iE&iM in cardiac surgery patients presenting with PH or signs of RV dysfunction is a safe and effective treatment approach in improving RV function. Appearance of a transient incre...
The role of intravenous (IV) inotropes in the treatment of ambulatory patients with advanced heart failure (HF) remains controversial....
This was a retrospective study of patients with advanced HF. Patients on home IV milrinone, who remained on it for at least 3 months, were included. We compared the data from 3 months before starting ...
A total of 90 patients remained on continuous IV milrinone for 3 months, and 55 patients were treated for 6 months or longer. In both groups, improvements in cardiac index (1.86-2.25, p<0.001 and 1.9-...
Long-term IV use of milrinone is associated with improvement in haemodynamics, functional class, tolerance of medical therapy, and decrease in hospitalised days....
This study aims to determine the incidence of all-cause hospitalization in patients with advanced heart failure (AHF) receiving ambulatory continuous, intravenous dobutamine versus milrinone for palli...
We sought to describe and compare outcomes among advanced patients with heart failure (not candidates for orthotopic heart transplant/left ventricular assist device) on long-term milrinone or dobutami...
We included adults with refractory stage D heart failure who were not candidates for orthotopic heart transplant or left ventricular assist device and discharged on palliative dobutamine or milrinone....
The 1-year mortality from palliative inotropes remains high. Compared with dobutamine, use of milrinone was associated with improved survival owing to better optimization of guideline-directed medical...