questionsmedicales.fr
Phénomènes microbiologiques
Interactions microbiennes
Interactions microbiennes : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Dysbiose
Analyse microbiologique
Séquençage ADN
Métagénomique
Diversité microbienne
Analyse statistique
Symptômes
5
Déséquilibre microbien
Troubles digestifs
Infection opportuniste
Symptômes
Allergies
Réponse immunitaire
Infections bactériennes
Signes cliniques
Prévention
5
Prévention des infections
Hygiène
Alimentation
Flore microbienne
Traitements
5
Antibiotiques
Antifongiques
Probiotiques
Santé intestinale
Antibiotiques
Flore microbienne
Immunomodulateurs
Réponse immunitaire
Complications
5
Infections chroniques
Système immunitaire
Infections opportunistes
Immunodéprimés
Santé mentale
Déséquilibres microbiens
Antibiotiques
Résistance bactérienne
Facteurs de risque
5
Facteurs de risque
Immunodépression
Médicaments
Flore microbienne
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Interactions microbiennes : Questions médicales les plus fréquentes",
"headline": "Interactions microbiennes : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Interactions microbiennes : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-06-01",
"dateModified": "2025-02-26",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Interactions microbiennes"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Phénomènes microbiologiques",
"url": "https://questionsmedicales.fr/mesh/D008827",
"about": {
"@type": "MedicalCondition",
"name": "Phénomènes microbiologiques",
"code": {
"@type": "MedicalCode",
"code": "D008827",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "G06"
}
}
},
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Détection du quorum",
"alternateName": "Quorum Sensing",
"url": "https://questionsmedicales.fr/mesh/D053038",
"about": {
"@type": "MedicalCondition",
"name": "Détection du quorum",
"code": {
"@type": "MedicalCode",
"code": "D053038",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "G06.550.700"
}
}
}
],
"about": {
"@type": "MedicalCondition",
"name": "Interactions microbiennes",
"alternateName": "Microbial Interactions",
"code": {
"@type": "MedicalCode",
"code": "D056265",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Rachel J Dutton",
"url": "https://questionsmedicales.fr/author/Rachel%20J%20Dutton",
"affiliation": {
"@type": "Organization",
"name": "School of Biological Science, University of California San Diego, San Diego, 92093, USA. rjdutton@ucsd.edu."
}
},
{
"@type": "Person",
"name": "Ophelia S Venturelli",
"url": "https://questionsmedicales.fr/author/Ophelia%20S%20Venturelli",
"affiliation": {
"@type": "Organization",
"name": "Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706."
}
},
{
"@type": "Person",
"name": "Alan R Pacheco",
"url": "https://questionsmedicales.fr/author/Alan%20R%20Pacheco",
"affiliation": {
"@type": "Organization",
"name": "Graduate Program in Bioinformatics and Biological Design Center, Boston University, 24 Cummington Mall, Boston, MA, 02215, USA."
}
},
{
"@type": "Person",
"name": "Daniel Segrè",
"url": "https://questionsmedicales.fr/author/Daniel%20Segr%C3%A8",
"affiliation": {
"@type": "Organization",
"name": "Graduate Program in Bioinformatics and Biological Design Center, Boston University, 24 Cummington Mall, Boston, MA, 02215, USA."
}
},
{
"@type": "Person",
"name": "Kai Feng",
"url": "https://questionsmedicales.fr/author/Kai%20Feng",
"affiliation": {
"@type": "Organization",
"name": "CAS Key Laboratory of Environmental Biotechnology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Establishment of a novel protocol for formalin-fixed paraffin-embedded organoids and spheroids.",
"datePublished": "2023-05-16",
"url": "https://questionsmedicales.fr/article/37191105",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1242/bio.059882"
}
},
{
"@type": "ScholarlyArticle",
"name": "Panfungal PCR on formalin-fixed, paraffin-embedded tissue: to proceed or not proceed?",
"datePublished": "2023-05-23",
"url": "https://questionsmedicales.fr/article/37316383",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.pathol.2023.03.011"
}
},
{
"@type": "ScholarlyArticle",
"name": "Residual Humidity in Paraffin-Embedded Tissue Reduces Nucleic Acid Stability.",
"datePublished": "2023-04-28",
"url": "https://questionsmedicales.fr/article/37175716",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/ijms24098010"
}
},
{
"@type": "ScholarlyArticle",
"name": "The Application of Guanidinium to Improve Biomolecule Quality in Fixed, Paraffin-embedded Tissue.",
"datePublished": "2023-03-04",
"url": "https://questionsmedicales.fr/article/36869703",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1369/00221554231159451"
}
},
{
"@type": "ScholarlyArticle",
"name": "Immunohistochemical detection of double-stranded RNA in formalin-fixed paraffin-embedded tissue.",
"datePublished": "2023-03-01",
"url": "https://questionsmedicales.fr/article/36776120",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1111/apm.13300"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Phénomènes microbiologiques",
"item": "https://questionsmedicales.fr/mesh/D008827"
},
{
"@type": "ListItem",
"position": 3,
"name": "Interactions microbiennes",
"item": "https://questionsmedicales.fr/mesh/D056265"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Interactions microbiennes - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Interactions microbiennes",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-10",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Interactions microbiennes",
"description": "Comment diagnostiquer une dysbiose microbienne ?\nQuels tests sont utilisés pour identifier les interactions microbiennes ?\nQuels signes indiquent une infection microbienne ?\nComment évaluer la diversité microbienne ?\nQuels marqueurs biologiques sont utilisés pour le diagnostic ?",
"url": "https://questionsmedicales.fr/mesh/D056265?mesh_terms=Paraffin+Embedding#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Interactions microbiennes",
"description": "Quels symptômes sont liés aux déséquilibres microbiens ?\nComment les interactions microbiennes affectent-elles la santé ?\nQuels symptômes indiquent une infection opportuniste ?\nLes allergies peuvent-elles être liées aux interactions microbiennes ?\nQuels signes cliniques sont associés aux infections bactériennes ?",
"url": "https://questionsmedicales.fr/mesh/D056265?mesh_terms=Paraffin+Embedding#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Interactions microbiennes",
"description": "Comment prévenir les infections microbiennes ?\nLes probiotiques peuvent-ils prévenir les infections ?\nQuelles mesures d'hygiène sont recommandées ?\nComment l'alimentation influence-t-elle la santé microbienne ?\nLes vaccinations aident-elles à prévenir les infections ?",
"url": "https://questionsmedicales.fr/mesh/D056265?mesh_terms=Paraffin+Embedding#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Interactions microbiennes",
"description": "Quels traitements sont efficaces contre les infections microbiennes ?\nComment les probiotiques influencent-ils les interactions microbiennes ?\nQuels sont les traitements pour la dysbiose ?\nLes antibiotiques affectent-ils la flore microbienne ?\nComment les traitements immunomodulateurs agissent-ils ?",
"url": "https://questionsmedicales.fr/mesh/D056265?mesh_terms=Paraffin+Embedding#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Interactions microbiennes",
"description": "Quelles complications peuvent survenir avec une dysbiose ?\nComment les infections microbiennes peuvent-elles devenir chroniques ?\nQuels risques sont associés aux infections opportunistes ?\nLes déséquilibres microbiens peuvent-ils affecter la santé mentale ?\nQuelles complications peuvent résulter d'un traitement antibiotique inapproprié ?",
"url": "https://questionsmedicales.fr/mesh/D056265?mesh_terms=Paraffin+Embedding#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Interactions microbiennes",
"description": "Quels facteurs augmentent le risque d'infections microbiennes ?\nComment le stress influence-t-il les interactions microbiennes ?\nL'alimentation joue-t-elle un rôle dans les infections ?\nQuels médicaments peuvent perturber la flore microbienne ?\nLes voyages peuvent-ils augmenter le risque d'infections ?",
"url": "https://questionsmedicales.fr/mesh/D056265?mesh_terms=Paraffin+Embedding#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une dysbiose microbienne ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un diagnostic se fait par analyse des échantillons microbiens et évaluation des symptômes."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour identifier les interactions microbiennes ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de culture, séquençage ADN et métagénomique sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une infection microbienne ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre, inflammation, douleur et fatigue sont des signes courants d'infection."
}
},
{
"@type": "Question",
"name": "Comment évaluer la diversité microbienne ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'évaluation se fait par des méthodes de séquençage et d'analyse statistique."
}
},
{
"@type": "Question",
"name": "Quels marqueurs biologiques sont utilisés pour le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les marqueurs incluent les cytokines, les métabolites et les biomarqueurs spécifiques."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés aux déséquilibres microbiens ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent troubles digestifs, fatigue, et infections récurrentes."
}
},
{
"@type": "Question",
"name": "Comment les interactions microbiennes affectent-elles la santé ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent provoquer des maladies, influencer l'immunité et le métabolisme."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une infection opportuniste ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre, éruptions cutanées et infections persistantes peuvent indiquer une infection opportuniste."
}
},
{
"@type": "Question",
"name": "Les allergies peuvent-elles être liées aux interactions microbiennes ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines interactions peuvent moduler la réponse immunitaire et provoquer des allergies."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques sont associés aux infections bactériennes ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Rougeur, chaleur, gonflement et douleur sont des signes cliniques d'infections bactériennes."
}
},
{
"@type": "Question",
"name": "Comment prévenir les infections microbiennes ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir une bonne hygiène, se faire vacciner et éviter les contacts à risque."
}
},
{
"@type": "Question",
"name": "Les probiotiques peuvent-ils prévenir les infections ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les probiotiques peuvent renforcer la barrière intestinale et prévenir certaines infections."
}
},
{
"@type": "Question",
"name": "Quelles mesures d'hygiène sont recommandées ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Se laver les mains régulièrement et désinfecter les surfaces sont essentielles."
}
},
{
"@type": "Question",
"name": "Comment l'alimentation influence-t-elle la santé microbienne ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en fibres et en probiotiques favorise une flore microbienne saine."
}
},
{
"@type": "Question",
"name": "Les vaccinations aident-elles à prévenir les infections ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les vaccinations protègent contre certaines infections bactériennes et virales."
}
},
{
"@type": "Question",
"name": "Quels traitements sont efficaces contre les infections microbiennes ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antibiotiques, antifongiques et antiviraux sont utilisés selon le type d'infection."
}
},
{
"@type": "Question",
"name": "Comment les probiotiques influencent-ils les interactions microbiennes ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les probiotiques rétablissent l'équilibre microbien et améliorent la santé intestinale."
}
},
{
"@type": "Question",
"name": "Quels sont les traitements pour la dysbiose ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des probiotiques, prébiotiques et modifications alimentaires."
}
},
{
"@type": "Question",
"name": "Les antibiotiques affectent-ils la flore microbienne ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les antibiotiques peuvent perturber la flore microbienne normale, causant des déséquilibres."
}
},
{
"@type": "Question",
"name": "Comment les traitements immunomodulateurs agissent-ils ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils modifient la réponse immunitaire pour aider à contrôler les infections microbiennes."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une dysbiose ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des maladies inflammatoires, allergies et infections chroniques."
}
},
{
"@type": "Question",
"name": "Comment les infections microbiennes peuvent-elles devenir chroniques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent persister si le système immunitaire est affaibli ou mal géré."
}
},
{
"@type": "Question",
"name": "Quels risques sont associés aux infections opportunistes ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les infections opportunistes peuvent entraîner des complications graves, surtout chez les immunodéprimés."
}
},
{
"@type": "Question",
"name": "Les déséquilibres microbiens peuvent-ils affecter la santé mentale ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des études montrent un lien entre déséquilibres microbiens et troubles mentaux."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent résulter d'un traitement antibiotique inapproprié ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Cela peut entraîner des résistances bactériennes et des infections secondaires."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'infections microbiennes ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge, le diabète, l'immunodépression et une mauvaise hygiène augmentent le risque."
}
},
{
"@type": "Question",
"name": "Comment le stress influence-t-il les interactions microbiennes ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress peut altérer la flore intestinale et affaiblir le système immunitaire."
}
},
{
"@type": "Question",
"name": "L'alimentation joue-t-elle un rôle dans les infections ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation déséquilibrée peut affaiblir l'immunité et favoriser les infections."
}
},
{
"@type": "Question",
"name": "Quels médicaments peuvent perturber la flore microbienne ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antibiotiques, les anti-inflammatoires et les immunosuppresseurs peuvent perturber la flore."
}
},
{
"@type": "Question",
"name": "Les voyages peuvent-ils augmenter le risque d'infections ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les voyages exposent à de nouveaux agents pathogènes et augmentent le risque d'infections."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 26/02/2025
Contenu vérifié selon les dernières recommandations médicales
2 publications dans cette catégorie
Affiliations :
School of Biological Science, University of California San Diego, San Diego, 92093, USA. rjdutton@ucsd.edu.
Publications dans "Interactions microbiennes" :
2 publications dans cette catégorie
Affiliations :
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706.
Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI 53706.
Publications dans "Interactions microbiennes" :
2 publications dans cette catégorie
Affiliations :
Graduate Program in Bioinformatics and Biological Design Center, Boston University, 24 Cummington Mall, Boston, MA, 02215, USA.
Publications dans "Interactions microbiennes" :
2 publications dans cette catégorie
Affiliations :
Graduate Program in Bioinformatics and Biological Design Center, Boston University, 24 Cummington Mall, Boston, MA, 02215, USA.
Department of Biomedical Engineering, Department of Biology and Department of Physics, Boston University, 24 Cummington Mall, Boston, MA, 02215, USA.
Publications dans "Interactions microbiennes" :
2 publications dans cette catégorie
Affiliations :
CAS Key Laboratory of Environmental Biotechnology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Publications dans "Interactions microbiennes" :
2 publications dans cette catégorie
Affiliations :
Institute of Marine Science and Technology, Shandong University, Qingdao, China.
Publications dans "Interactions microbiennes" :
2 publications dans cette catégorie
Affiliations :
CAS Key Laboratory of Environmental Biotechnology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Key Laboratory of Industrial Ecology and Environmental Engineering (MOE) and Dalian POCT Laboratory, School of Environmental Science and Technology, Dalian University of Technology, Dalian, China.
Publications dans "Interactions microbiennes" :
2 publications dans cette catégorie
Affiliations :
Institute of Marine Science and Technology, Shandong University, Qingdao, China.
CAS Key Laboratory of Environmental Biotechnology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, China.
Publications dans "Interactions microbiennes" :
2 publications dans cette catégorie
Affiliations :
Department of Biology, Boston College, Chestnut Hill, MA, 02467, USA. momeni@bc.edu.
Publications dans "Interactions microbiennes" :
2 publications dans cette catégorie
Affiliations :
Department of Plant & Microbial Biology, University of California, Berkeley, Berkeley, CA, USA. taga@berkeley.edu.
Publications dans "Interactions microbiennes" :
2 publications dans cette catégorie
Affiliations :
Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Wageningen, The Netherlands.
Publications dans "Interactions microbiennes" :
2 publications dans cette catégorie
Affiliations :
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA. luting@illinois.edu.
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. luting@illinois.edu.
Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA. luting@illinois.edu.
Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. luting@illinois.edu.
National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, USA. luting@illinois.edu.
Publications dans "Interactions microbiennes" :
1 publication dans cette catégorie
Affiliations :
Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA cmuzny@uabmc.edu.
Publications dans "Interactions microbiennes" :
1 publication dans cette catégorie
Affiliations :
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Publications dans "Interactions microbiennes" :
1 publication dans cette catégorie
Affiliations :
Centre of Biological Engineering, Laboratory of Research in Biofilms Rosário Oliveira (LIBRO), University of Minho-Gualtar Campus, Braga, Portugal.
Publications dans "Interactions microbiennes" :
1 publication dans cette catégorie
Affiliations :
Centre of Biological Engineering, Laboratory of Research in Biofilms Rosário Oliveira (LIBRO), University of Minho-Gualtar Campus, Braga, Portugal.
Publications dans "Interactions microbiennes" :
1 publication dans cette catégorie
Affiliations :
Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Publications dans "Interactions microbiennes" :
1 publication dans cette catégorie
Affiliations :
Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Publications dans "Interactions microbiennes" :
1 publication dans cette catégorie
Affiliations :
Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Publications dans "Interactions microbiennes" :
1 publication dans cette catégorie
Affiliations :
Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Publications dans "Interactions microbiennes" :
Three-dimensional (3D) cell culture models such as spheroids and organoids are widely used in the field of experimental biology. To analyze these 3D experimental models, formalin-fixed paraffin-embedd...
Performance of panfungal PCR-DNA sequencing assays for diagnosis of invasive fungal disease on formalin-fixed, paraffin-embedded tissue (FFPE) is influenced by many variables. Interpretation of a posi...
Molecular diagnostics in healthcare relies increasingly on genomic and transcriptomic methodologies and requires appropriate tissue specimens from which nucleic acids (NA) of sufficiently high quality...
Neutral buffered formalin (NBF) is the most common fixative in clinical applications. However, NBF damages proteins and nucleic acids, limiting the quality of proteomic and nucleic acid-based assays. ...
Double-stranded RNA (dsRNA) is produced during most viral infections, and immunohistochemical detection of dsRNA has been proposed as a potential screening marker for viral replication. The anti-dsRNA...
The relatively recent developments in mass spectrometry (MS) have provided novel opportunities for this technology to impact modern medicine. One of those opportunities is in biomarker discovery and d...
Positive and negative controls with known expression of target proteins are essential for the development of immunohistochemistry (IHC) assays. While tissue controls are beneficial for well-characteri...
The continued development in methylome analysis has enabled a more precise assessment of DNA methylation, but treatment of target tissue prior to analysis may affect DNA analysis. Prediction of age ba...
Determination of isocitrate dehydrogenase (IDH) 1/2 mutational status is crucial for a glioma diagnosis. It is common for IDH mutational status to be determined via a two-step algorithm that utilizes ...
Concordance between the RT-PCR and sequencing and IHC studies was 100%. This RT-PCR assay also showed concordant results with IHC for IDH1 R132H for 11 of the 12 (92%) tumor specimens with IDH mutatio...
In summary, we report that this RT-PCR assay can reliably be performed on formalin-fixed paraffin-embedded specimens and has a faster turnaround time than sequencing assays and can be clinically imple...
BRCA-deficient breast cancers (BC) are highly sensitive to platinum-based chemotherapy and PARP inhibitors due to their deficiency in the homologous recombination (HR) pathway. However, HR deficiency ...
The functional HR status of 63 diagnostic formalin-fixed paraffin-embedded (FFPE) BC samples was determined by applying the RAD51-FFPE test. Samples were screened for the presence of (epi)genetic defe...
The RAD51-FFPE test identified 23 (37%) of the tumors as HRD, including three tumors with pathogenic variants in BRCA1/2. The RAD51-FFPE test showed a sensitivity of 88% and a specificity of 76% in de...
Given its high sensitivity and compatibility with FFPE samples, the RAD51-FFPE test holds great potential to enrich for HRD tumors, including those associated with BRCA-deficiency. This potential exte...