Comment diagnostiquer une dysfonction de PI3K ?

Des tests génétiques et des analyses biochimiques peuvent être utilisés pour diagnostiquer les anomalies de PI3K.

Quels tests sont utilisés pour évaluer PI3K ?

Les tests d'activité enzymatique et les dosages de métabolites spécifiques sont courants.

Les biopsies sont-elles nécessaires pour le diagnostic ?

Des biopsies peuvent être nécessaires pour évaluer l'expression de PI3K dans les tissus.

Quels symptômes peuvent indiquer un problème avec PI3K ?

Des symptômes variés comme des troubles métaboliques ou des anomalies de croissance peuvent survenir.

Y a-t-il des marqueurs spécifiques pour PI3K ?

Des marqueurs moléculaires comme PIK3CA peuvent indiquer une activation anormale de PI3K.

Quels sont les symptômes d'une activation anormale de PI3K ?

Les symptômes incluent des troubles métaboliques, des anomalies de croissance et des cancers.

Comment PI3K affecte-t-il le métabolisme ?

PI3K régule le métabolisme en influençant la signalisation de l'insuline et la lipogenèse.

Les troubles neurologiques sont-ils liés à PI3K ?

Oui, des dysfonctionnements de PI3K peuvent être associés à des troubles neurologiques.

Y a-t-il des signes cutanés associés à PI3K ?

Des anomalies cutanées peuvent apparaître, notamment dans des syndromes génétiques liés à PI3K.

Les douleurs articulaires peuvent-elles être liées à PI3K ?

Oui, des troubles inflammatoires peuvent être exacerbés par des anomalies de PI3K.

Peut-on prévenir les troubles liés à PI3K ?

Une alimentation saine et un mode de vie actif peuvent réduire les risques associés à PI3K.

Y a-t-il des tests de dépistage pour PI3K ?

Des tests génétiques peuvent être recommandés pour les personnes à risque de troubles liés à PI3K.

Les habitudes alimentaires influencent-elles PI3K ?

Oui, une alimentation riche en acides gras oméga-3 peut moduler l'activité de PI3K.

L'exercice physique aide-t-il à réguler PI3K ?

Oui, l'exercice régulier peut améliorer la signalisation de PI3K et la santé métabolique.

Les facteurs environnementaux affectent-ils PI3K ?

Oui, l'exposition à certains toxiques peut influencer l'activité de PI3K et le risque de maladies.

Quels traitements ciblent PI3K ?

Des inhibiteurs de PI3K sont utilisés dans le traitement de certains cancers et maladies métaboliques.

Les thérapies géniques peuvent-elles aider ?

Oui, la thérapie génique peut corriger des mutations dans les gènes codant pour PI3K.

Y a-t-il des effets secondaires des inhibiteurs de PI3K ?

Les effets secondaires peuvent inclure des troubles gastro-intestinaux et des infections.

Comment la nutrition influence-t-elle PI3K ?

Une alimentation équilibrée peut moduler l'activité de PI3K et améliorer la santé métabolique.

Les traitements sont-ils personnalisés pour PI3K ?

Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques de PI3K.

Quelles complications peuvent survenir avec PI3K ?

Des complications incluent des cancers, des troubles métaboliques et des maladies cardiovasculaires.

Les maladies cardiovasculaires sont-elles liées à PI3K ?

Oui, des anomalies de PI3K peuvent contribuer à des maladies cardiovasculaires par des mécanismes inflammatoires.

Comment PI3K influence-t-il le cancer ?

PI3K est souvent activé dans divers cancers, favorisant la croissance tumorale et la survie cellulaire.

Y a-t-il des risques de résistance aux traitements ?

Oui, des mutations dans PI3K peuvent entraîner une résistance aux inhibiteurs de PI3K.

Les troubles métaboliques sont-ils réversibles ?

Certains troubles métaboliques liés à PI3K peuvent être gérés par des changements de mode de vie.

Quels sont les facteurs de risque pour les troubles de PI3K ?

Les facteurs incluent des prédispositions génétiques, l'obésité et un mode de vie sédentaire.

L'âge influence-t-il le risque lié à PI3K ?

Oui, le risque de troubles liés à PI3K augmente avec l'âge en raison de l'accumulation de mutations.

Le stress a-t-il un impact sur PI3K ?

Oui, le stress chronique peut affecter la signalisation de PI3K et contribuer à des maladies.

Les antécédents familiaux jouent-ils un rôle ?

Oui, des antécédents familiaux de cancers ou de troubles métaboliques augmentent le risque.

L'alimentation influence-t-elle le risque de troubles de PI3K ?

Oui, une alimentation riche en sucres et graisses saturées peut augmenter le risque.

Phosphatidylinositol-4-phosphate 3-kinase - Informations médicales vérifiées

Lipoplasty in the Overweight Patient.

Jan 2024

DOI: 10.1016/j.cps.2023.06.010 PMID: 37945074

The practice of large volume liposuction, when executed by board-certified plastic surgeons using a variety of energy-assisted liposuction devices, has been substantiated as a secure procedure, yieldi...

Humans Lipectomy Overweight Postoperative Care Skin +1 autres

Boys with overweight status lagged behind girls with overweight status in reading: evidence from mendelian randomization.

07 2023

DOI: 10.1016/j.jclinepi.2023.05.001 PMID: 37156340

We investigated the relationship between childhood weight status and academic achievement across sexes and different school subjects in Norway.... We used data from the Norwegian Mother, Father and Child Cohort Study (MoBa), which includes genetic data (N = 13,648, 8-year-old children). We employed within-family mendelian randomization, using a ... Contrary to most previous findings, we observed that overweight status (including obesity) has more detrimental effects on reading achievement in boys than in girls; the test scores of boys with overw... Previous obesity prevention studies have mainly targeted girls, based on the assumption that the obesity penalty is greater for girls. Our findings highlight that particular attention to boys with ove...

Male Child Female Humans Overweight +4 autres

Overweight grandsons and grandfathers' starvation exposure.

09 2023

DOI: 10.1016/j.jhealeco.2023.102796 PMID: 37541079

Much of the increase in the prevalence of overweight and obesity has been in developing countries with a history of famines and malnutrition. This paper is the first to examine overweight among adult ...

Adult Humans Male Middle Aged Grandparents +3 autres

Homocysteine concentrations in overweight children and adolescents.

2023

DOI: 10.1590/1806-9282.20220991 PMID: 36722654

The aim of this study was to describe homocysteine concentrations in overweight and obese children and adolescents and relate them to blood pressure levels, renal function, and insulin resistance.... This is a cross-sectional and observational study with 64 overweight children and adolescents (mean age: 11.6±3.5 years) in outpatient follow-up. The following parameters were evaluated: body mass ind... The mean body mass index z-score was 2.9±1.1. The mean homocysteine concentrations were 8.6±2.2 μmol/L (10th and 90th percentiles: 6.6 and 11.2 μmol/L, respectively), with no difference when compared ... Homocysteine concentrations in overweight children and adolescents (mean 8.6±2.2 μmol/L) were not associated with body mass index z-score, blood pressure, renal function, and insulin resistance....

Adolescent Child Humans Blood Pressure Body Mass Index +6 autres

Cancers attributable to overweight and obesity in Italy.

Dec 2023

DOI: 10.1016/j.canep.2023.102468 PMID: 37832242

Overweight and obesity are associated with multiple cancers. We quantified the burden of cancer attributable to overweight and obesity in Italy.... We estimated sex- and cancer site-specific population attributable fractions (PAFs) combining relative risks (from recent meta-analyses) with national obesity prevalence data (from a large sample surv... 3.6% of cancers in men and 4.0% in women in Italy were attributable to overweight and obesity, corresponding, respectively, to over 6900 and 7200 diagnoses in 2020. Attributable deaths were over 3600 ... The cancer burden associated with overweight and obesity in Italy is considerable, but smaller compared to other high income countries, likely because of the lower prevalence of overweight and obesity...

Male Female Humans Overweight Risk Factors +6 autres

Impact of overweight and obesity in postmenopausal women.

Dec 2023

DOI: 10.1080/13697137.2023.2228692 PMID: 37477988

This study aimed to investigate the association between overweight and obesity in postmenopausal women and different aspects related to health such as quality of life, physical activity, sleep quality... An observational cross-sectional study was carried out during 2021-2022 in Spain in postmenopausal women. Health-related quality of life was assessed using the 12-item short-form survey (SF-12). The P... A total of 395 postmenopausal women participated: 64.6% (... Obesity in postmenopausal women negatively affects perceived quality of life, sleep quality, physical activity, the development of cardiovascular problems and pelvic floor-related problems....

Female Humans Overweight Quality of Life Postmenopause +2 autres

Gene-Environment Interplay in the Development of Overweight.

09 2023

DOI: 10.1016/j.jadohealth.2023.04.028 PMID: 37318409

Overweight in youth is influenced by genes and environment. Gene-environment interaction (G×E) has been demonstrated in twin studies and recent developments in genetics allow for studying G×E using in... Latent class growth models of overweight were fitted using data from the TRacking Adolescents' Individual Lives Survey (n = 2720). A polygenic score for body mass index (BMI) was derived using summary... A three-class model of developmental pathways of overweight fitted the data best ("non-overweight", "adolescent-onset overweight", and "persistent overweight"). The polygenic score for BMI and socioec... Higher genetic predisposition increased the risk of developing overweight during adolescence and young adulthood and was associated with an earlier age at onset. We did not find that genetic predispos...

Adult Adolescent Humans Young Adult Longitudinal Studies +7 autres

Calcium supplementation for people with overweight or obesity.

09 May 2024

DOI: 10.1002/14651858.CD012268.pub2 PMID: 38721870

Obesity is a major health problem worldwide as it can lead to high blood pressure, heart disease, stroke, diabetes, and insulin resistance. The prevalence of overweight and obesity is increasing world... To assess the effects of calcium supplementation on weight loss in individuals living with overweight or obesity.... We searched CENTRAL, MEDLINE, Embase, LILACS (Latin American and Caribbean Health Science Information database), and two clinical trials registries. The date of the last search of all databases (excep... We included randomised controlled trials evaluating the effect of calcium in participants with overweight or obesity of any age or gender. We excluded studies in participants with absorption problems.... We used standard methodological procedures expected by Cochrane. Our primary outcomes were body weight, health-related quality of life, and adverse events. Our secondary outcomes were anthropometric m... We found 18 studies that evaluated the effect of calcium compared to placebo or control, with a total of 1873 randomised participants (950 participants in the calcium supplementation groups and 923 in... Calcium supplementation for eight weeks to 24 months may result in little to no difference in body weight in people with overweight or obesity. The current evidence is of low certainty, due to concern...

Humans Randomized Controlled Trials as Topic Overweight Obesity Dietary Supplements +10 autres

Fish Oil And/Or Probiotics Intervention in Overweight/Obese Pregnant Women and Overweight Risk in 24-Month-Old Children.

01 02 2023

DOI: 10.1097/MPG.0000000000003659 PMID: 36705702

To evaluate whether a fish oil and/or probiotics intervention in pregnant women with overweight or obesity would influence the tendency of their 24-month-old children to become overweight and alter th... Women (n = 439) were double-blindly randomized into 4 intervention groups: fish oil+placebo, probiotics+placebo, probiotics+fish oil, and placebo+placebo (fish oil: 1.9 g docosahexaenoic acid and 0.22... Probiotics+placebo [weight-for-height% adj. Odds ratio (OR) = 0.36, 95% confidence interval (CI) = 0.14-0.95] and probiotics+fish oil [weight-for-age standard deviation score (SD-score) adj. OR = 0.22... The administration of probiotics solely and in combination with fish oil during pregnancy to women with overweight or obesity lowered the overweight odds of their 24-month-old children....

Child Female Humans Pregnancy Bifidobacterium animalis +6 autres

Inflammatory profile associated with insulin resistance in non-overweight versus overweight people living with HIV in Pune, Western India.

Jul 2022

DOI: 10.1016/j.dsx.2022.102551 PMID: 35777254

People living with HIV have greater diabetes (T2DM) than the general population despite lower prevalence of overweight/obesity. Both insulin resistance (IR), a T2DM precursor, and HIV are independentl... To study the association between inflammation and IR in non-overweight and overweight people living with HIV.... In a cohort of adult people living with HIV with undetectable viral load in Pune, India, we measured fasting insulin, glucose, and 9 inflammatory markers. IR was defined as HOMA-IR ≥2, and non-overwei... Of 288 participants, 66% (n = 189) were non-overweight. Among non-overweight, prevalence of IR was 34% (n = 65). Each doubling of MCP-1 and leptin was associated with IR on univariate analysis (preval... One in 3 non-overweight people living with HIV in India with controlled viremia have IR. Leptin was associated with IR among non-overweight people living with HIV and may provide insight into the path...

Adult Biomarkers Body Mass Index Diabetes Mellitus, Type 2 HIV Infections +7 autres

Phosphatidylinositol-4-phosphate 3-kinase : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Phosphatidylinositol 3-kinases de classe I

Phosphatidylinositol 3-kinases de classe II

Phosphatidylinositol 3-kinase de classe Ia

Phosphatidylinositol 3-kinases de classe Ib

Auteurs principaux

Sources (4642 au total)