questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Protéines et peptides de signalisation intracellulaire
Phosphatidylinositol 3-kinases
Phosphatidylinositol-4-phosphate 3-kinase
Phosphatidylinositol-4-phosphate 3-kinase : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Kinases
Diagnostic médical
Tests de laboratoire
Phosphatidylinositols
Biopsie
Phosphatidylinositols
Symptômes
Phosphatidylinositols
Marqueurs biologiques
Phosphatidylinositols
Symptômes
5
Symptômes
Phosphatidylinositols
Troubles neurologiques
Phosphatidylinositols
Anomalies cutanées
Phosphatidylinositols
Douleurs articulaires
Phosphatidylinositols
Prévention
5
Prévention
Mode de vie sain
Dépistage
Tests génétiques
Habitudes alimentaires
Phosphatidylinositols
Exercice physique
Métabolisme
Facteurs environnementaux
Phosphatidylinositols
Traitements
5
Inhibiteurs
Traitement du cancer
Thérapie génique
Phosphatidylinositols
Effets secondaires
Inhibiteurs
Médecine personnalisée
Phosphatidylinositols
Complications
5
Complications
Phosphatidylinositols
Maladies cardiovasculaires
Phosphatidylinositols
Cancer
Phosphatidylinositols
Résistance aux traitements
Phosphatidylinositols
Troubles métaboliques
Phosphatidylinositols
Facteurs de risque
5
Facteurs de risque
Obésité
Âge
Phosphatidylinositols
Stress
Phosphatidylinositols
Antécédents familiaux
Phosphatidylinositols
Alimentation
Phosphatidylinositols
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"name": "Comment diagnostiquer une dysfonction de PI3K ?",
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"text": "Des tests génétiques et des analyses biochimiques peuvent être utilisés pour diagnostiquer les anomalies de PI3K."
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"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer PI3K ?",
"position": 2,
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"@type": "Question",
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"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec PI3K ?",
"position": 4,
"acceptedAnswer": {
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"@type": "Question",
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"@type": "Question",
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"@type": "Question",
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"@type": "Question",
"name": "Les troubles neurologiques sont-ils liés à PI3K ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des dysfonctionnements de PI3K peuvent être associés à des troubles neurologiques."
}
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{
"@type": "Question",
"name": "Y a-t-il des signes cutanés associés à PI3K ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies cutanées peuvent apparaître, notamment dans des syndromes génétiques liés à PI3K."
}
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{
"@type": "Question",
"name": "Les douleurs articulaires peuvent-elles être liées à PI3K ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles inflammatoires peuvent être exacerbés par des anomalies de PI3K."
}
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"@type": "Question",
"name": "Peut-on prévenir les troubles liés à PI3K ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation saine et un mode de vie actif peuvent réduire les risques associés à PI3K."
}
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{
"@type": "Question",
"name": "Y a-t-il des tests de dépistage pour PI3K ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques peuvent être recommandés pour les personnes à risque de troubles liés à PI3K."
}
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{
"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles PI3K ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en acides gras oméga-3 peut moduler l'activité de PI3K."
}
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{
"@type": "Question",
"name": "L'exercice physique aide-t-il à réguler PI3K ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la signalisation de PI3K et la santé métabolique."
}
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"@type": "Question",
"name": "Les facteurs environnementaux affectent-ils PI3K ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certains toxiques peut influencer l'activité de PI3K et le risque de maladies."
}
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"@type": "Question",
"name": "Quels traitements ciblent PI3K ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs de PI3K sont utilisés dans le traitement de certains cancers et maladies métaboliques."
}
},
{
"@type": "Question",
"name": "Les thérapies géniques peuvent-elles aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la thérapie génique peut corriger des mutations dans les gènes codant pour PI3K."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets secondaires des inhibiteurs de PI3K ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires peuvent inclure des troubles gastro-intestinaux et des infections."
}
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{
"@type": "Question",
"name": "Comment la nutrition influence-t-elle PI3K ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut moduler l'activité de PI3K et améliorer la santé métabolique."
}
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"@type": "Question",
"name": "Les traitements sont-ils personnalisés pour PI3K ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques de PI3K."
}
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{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec PI3K ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des cancers, des troubles métaboliques et des maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Les maladies cardiovasculaires sont-elles liées à PI3K ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anomalies de PI3K peuvent contribuer à des maladies cardiovasculaires par des mécanismes inflammatoires."
}
},
{
"@type": "Question",
"name": "Comment PI3K influence-t-il le cancer ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "PI3K est souvent activé dans divers cancers, favorisant la croissance tumorale et la survie cellulaire."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de résistance aux traitements ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des mutations dans PI3K peuvent entraîner une résistance aux inhibiteurs de PI3K."
}
},
{
"@type": "Question",
"name": "Les troubles métaboliques sont-ils réversibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains troubles métaboliques liés à PI3K peuvent être gérés par des changements de mode de vie."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les troubles de PI3K ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des prédispositions génétiques, l'obésité et un mode de vie sédentaire."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque lié à PI3K ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque de troubles liés à PI3K augmente avec l'âge en raison de l'accumulation de mutations."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur PI3K ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter la signalisation de PI3K et contribuer à des maladies."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de cancers ou de troubles métaboliques augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle le risque de troubles de PI3K ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en sucres et graisses saturées peut augmenter le risque."
}
}
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 27/02/2025
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Cellular Organization and Signaling, National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore, 560065, India. Electronic address: praghu@ncbs.res.in.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India; Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, 611-0011 Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, 611-0011 Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, 611-0011 Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Section on Molecular Signal Transduction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA ballat@mail.nih.gov.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany. haucke@fmp-berlin.de.
Departments of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany. haucke@fmp-berlin.de.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Medical Research Institute, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan. Electronic address: afujita@vet.kagoshima-u.ac.jp.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
Department of Biochemistry, University of Toronto, ON, M5S 1A8, Toronto, Canada. greg.fairn@unityhealth.to.
Keenan Research Centre for Biomedical Sciences, St. Michael's Hospital, 209 Victoria Street, Toronto, ON, M5B 1T8, Canada. greg.fairn@unityhealth.to.
Department of Surgery, University of Toronto, Toronto, ON, M5T 1P5, Canada. greg.fairn@unityhealth.to.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
Temperature is one of the most important factors in all living organisms for survival. Being a unicellular organism, bacterium requires sensitive sensing and defense mechanisms to tolerate changes in ...
While fluctuations in healthy brain temperature have been investigated over time periods of weeks to months, dynamics over shorter time periods are less clear....
To identify physiological fluctuations in brain temperature in healthy volunteers over time scales of approximately 1 hour....
Prospective....
A total of 30 healthy volunteers (15 female; 26 ± 4 years old)....
3 T; T1-weighted magnetization-prepared rapid gradient-echo (MPRAGE) and semi-localized by adiabatic selective refocusing (sLASER) single-voxel spectroscopy....
Brain temperature was calculated from the chemical shift difference between N-acetylaspartate and water. To evaluate within-scan repeatability of brain temperature and the brain-body temperature diffe...
A hierarchical linear mixed model was used to calculate within-scan and between-scan correlations (R...
A significant difference in brain temperature was observed between scans (-0.4 °C) but body temperature was stable (P = .59). Brain temperature (37.9 ± 0.7 °C) was higher than body temperature (36.5 ±...
Significant changes in brain temperature over time scales of ~1 hour were observed. High short-term repeatability suggests temperature changes appear to be due to physiology rather than measurement er...
2 TECHNICAL EFFICACY: Stage 1....
The development of new analytical methods can save resources, time and costs if there are prediction tools like computer simulation which support the optimization process. In GC the distribution-centr...
When the ambient temperature, in which a person is situated, fluctuates, the body's surface temperature will alter proportionally. However, the body's core temperature will remain relatively steady. C...
Plan an experiment to measure temperature over a thousand times in order to get the corresponding data for human forehead, axillary, and oral temperatures at varying ambient temperatures (14-32 °C). U...
A total of 1080 tests measuring body temperature were conducted on healthy adults. The average axillary temperature was (36.7 ± 0.41) °C, the average oral temperature was (36.7 ± 0.33) °C, and the ave...
The changes in ambient temperature have a substantial impact on the temperature of the forehead. There are significant differences between the forehead and axillary temperatures, as well as the forehe...
Flexible temperature sensors with high resolution and good reliability under deformation are a major research focus for wearable electronic devices for skin temperature monitoring. In this study, a fi...
The inverse association between ambient temperature and blood pressure (BP) has been investigated in the context of excess cardiovascular mortality in winter. However, the role of skin temperature (ST...
We conducted a longitudinal analysis using repeated measurements of ambulatory BP and ST for 48 hours (30 711 daytime readings and 17 382 nighttime readings) among 584 older adults between October and...
Distal and proximal STs were significantly associated with systolic BP during the daytime (regression coefficients: -4.27 mm Hg [95% CI, -4.58 to -3.96] and -2.74 mm Hg [95% CI, -3.14 to -2.56] per SD...
ST, especially in distal regions, was inversely associated with ambulatory BP. Our results have the potential for application to interventional studies targeting ST regulation to reduce excess cardiov...
Neonatal encephalopathy is a clinical condition of altered neurological function in the first days of life. Targeted temperature management (TTM) is a validated approach to mitigate neurologic sequela...
A female newborn was born at 39 weeks' gestational age plus 4 days. At delivery, the newborn was in cardiorespiratory arrest....
After performing cardiopulmonary resuscitation and neurological examination, a hypoxic-ischemic encephalopathy was diagnosed....
After about 2 hours from birth, the newborn underwent TTM....
A total of 4642 measurements of rectal temperature and 4520 measurements of bladder temperature were collected. Agreement between the 2 sites was statistically significant with a mean difference of 0....
Bladder temperature seems to have a good reliability and not to be inferior to the other assessment site currently used. Using bladder catheter with temperature sensor could reduce the number of devic...
Despite their relatively high thermal optima (T...
Loop-mediated isothermal amplification (LAMP) is one of the most widely used isothermal amplification technologies in molecular diagnostics. However, LAMP operates at a high temperature of 65 °C; thus...
For the first time, the use of stannate-based sorbents was investigated as high temperature CO...