Finite element analysis of zonular forces.
To determine the effect of zonular forces on lens capsule topography, a finite element (FE) analyses of lens capsules with no lens stroma and constant and variable thickness with anterior capsulotomie...
N-terminal acetyltransferase E : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une déficience en N-terminal acetyltransferase E ?
Le diagnostic repose sur des tests génétiques et des analyses enzymatiques.
#2
Quels tests sont utilisés pour évaluer l'activité de cette enzyme ?
Des tests biochimiques mesurant l'acétylation des protéines sont utilisés.
#3
Y a-t-il des biomarqueurs associés à cette enzyme ?
Actuellement, il n'existe pas de biomarqueurs spécifiques largement reconnus.
#4
Quels symptômes peuvent indiquer un problème avec cette enzyme ?
Des troubles métaboliques ou neurologiques peuvent suggérer une anomalie.
#5
Peut-on détecter des mutations génétiques liées à cette enzyme ?
Oui, des mutations dans le gène codant pour l'enzyme peuvent être identifiées.
Symptômes 5
#1
Quels sont les symptômes d'une déficience en N-terminal acetyltransferase E ?
Les symptômes peuvent inclure des troubles neurologiques et des anomalies de croissance.
#2
Les symptômes varient-ils selon l'âge ?
Oui, les symptômes peuvent se manifester différemment selon l'âge du patient.
#3
Y a-t-il des symptômes spécifiques à surveiller ?
Des retards de développement et des troubles cognitifs sont à surveiller.
#4
Les symptômes sont-ils réversibles ?
Certains symptômes peuvent être gérés, mais d'autres peuvent être permanents.
#5
Comment les symptômes évoluent-ils avec le temps ?
Les symptômes peuvent s'aggraver avec le temps sans intervention appropriée.
Prévention 5
#1
Peut-on prévenir les troubles liés à cette enzyme ?
La prévention est difficile, mais un diagnostic précoce peut aider à gérer les symptômes.
#2
Y a-t-il des conseils diététiques pour les patients ?
Une alimentation équilibrée et riche en nutriments est recommandée.
#3
Les tests génétiques peuvent-ils aider à la prévention ?
Oui, les tests génétiques peuvent identifier les porteurs et les risques.
#4
Les vaccinations sont-elles importantes pour ces patients ?
Les vaccinations sont importantes pour prévenir les infections, surtout chez les enfants.
#5
Comment le suivi médical aide-t-il à la prévention ?
Un suivi régulier permet d'identifier et de traiter rapidement les complications.
Traitements 5
#1
Quels traitements sont disponibles pour cette condition ?
Les traitements incluent la thérapie symptomatique et le soutien nutritionnel.
#2
Y a-t-il des médicaments spécifiques pour cette enzyme ?
Actuellement, il n'existe pas de médicaments spécifiques ciblant cette enzyme.
#3
La thérapie génique est-elle une option ?
La thérapie génique est en recherche, mais pas encore disponible cliniquement.
#4
Comment la physiothérapie peut-elle aider ?
La physiothérapie peut améliorer la mobilité et la fonction physique des patients.
#5
Les traitements sont-ils personnalisés ?
Oui, les traitements peuvent être adaptés en fonction des symptômes et des besoins.
Complications 5
#1
Quelles complications peuvent survenir avec cette condition ?
Les complications incluent des troubles neurologiques graves et des retards de développement.
#2
Les complications sont-elles évitables ?
Certaines complications peuvent être évitées avec un traitement précoce et approprié.
#3
Comment les complications affectent-elles la qualité de vie ?
Les complications peuvent significativement réduire la qualité de vie des patients.
#4
Y a-t-il des risques de complications à long terme ?
Oui, des risques de complications à long terme existent sans intervention adéquate.
#5
Les complications peuvent-elles être gérées ?
Oui, de nombreuses complications peuvent être gérées avec un suivi médical approprié.
Facteurs de risque 5
#1
Quels sont les facteurs de risque associés à cette enzyme ?
Les facteurs de risque incluent des antécédents familiaux et des mutations génétiques.
#2
L'environnement joue-t-il un rôle dans cette condition ?
Des facteurs environnementaux peuvent influencer l'expression des gènes liés à l'enzyme.
#3
Les facteurs de risque sont-ils modifiables ?
Certains facteurs, comme le mode de vie, peuvent être modifiés pour réduire les risques.
#4
Y a-t-il des groupes à risque plus élevé ?
Oui, les individus avec des antécédents familiaux de troubles métaboliques sont à risque.
#5
Les tests de dépistage sont-ils recommandés pour les familles à risque ?
Oui, le dépistage génétique est recommandé pour les familles avec des antécédents.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 27/02/2025
Contenu vérifié selon les dernières recommandations médicales
Auteurs principaux
Thomas Arnesen
10 publications dans cette catégorie
Affiliations :
- Department of Biological Sciences, University of Bergen, Bergen, Norway.
- Department of Biomedicine, University of Bergen, Bergen, Norway.
- Department of Surgery, Haukeland University Hospital, Bergen, Norway.
Publications dans "N-terminal acetyltransferase E" :
-
Dynamics-function relationship in the catalytic domains of N-terminal acetyltransferases.
Computational and structural biotechnology journal 2020-03-03
-
Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80.
Frontiers in chemistry 2023-06-20
-
Using cell lysates to assess N-terminal acetyltransferase activity and impairment.
Methods in enzymology 2023-03-24
-
Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
The Journal of biological chemistry 2022-12-22
-
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.
Molecular cell 2019-03-13
Ronen Marmorstein
5 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Pennsylvania, Philadelphia, PA, United States; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Electronic address: marmor@upenn.edu.
Publications dans "N-terminal acetyltransferase E" :
-
Biochemical and structural analysis of N-terminal acetyltransferases.
Methods in enzymology 2019-08-12
-
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.
Journal of medicinal chemistry 2021-06-10
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
bioRxiv : the preprint server for biology 2023-04-03
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
Sunbin Deng
4 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Publications dans "N-terminal acetyltransferase E" :
-
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.
Journal of medicinal chemistry 2021-06-10
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
bioRxiv : the preprint server for biology 2023-04-03
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
Antonis Kirmizis
4 publications dans cette catégorie
Affiliations :
- Epigenetics and Gene Regulation Laboratory, Department of Biological Sciences, University of Cyprus, Nicosia 2109, Cyprus.
Publications dans "N-terminal acetyltransferase E" :
-
Biochemical Characterisation of the Short Isoform of Histone N-Terminal Acetyltransferase NAA40.
Biomolecules 2024-09-02
-
N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours.
Cancers 2020-09-15
-
Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance.
Oncogene 2021-11-16
-
Yeast Nat4 regulates DNA damage checkpoint signaling through its N-terminal acetyltransferase activity on histone H4.
PLoS genetics 2024-10-02
Henriette Aksnes
4 publications dans cette catégorie
Affiliations :
- Department of Biomedicine, University of Bergen, Bergen, Norway. Electronic address: henriette.aksnes@uib.no.
Publications dans "N-terminal acetyltransferase E" :
-
Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
The Journal of biological chemistry 2022-12-22
-
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.
Molecular cell 2019-03-13
-
Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae.
Nature communications 2023-07-27
-
Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly.
Genetics in medicine : official journal of the American College of Medical Genetics 2021-07-06
Owen A Collars
3 publications dans cette catégorie
Affiliations :
- Department of Biological Sciences, University of Notre Dame , Notre Dame, Indiana, USA.
- Eck Institute for Global Health, University of Note Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferase E" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Daniel D Hu
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferase E" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Simon D Weaver
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferase E" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Matthew M Champion
3 publications dans cette catégorie
Affiliations :
- Eck Institute for Global Health, University of Note Dame , Notre Dame, Indiana, USA.
- Department of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferase E" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Patricia A Champion
3 publications dans cette catégorie
Affiliations :
- Department of Biological Sciences, University of Notre Dame , Notre Dame, Indiana, USA.
- Eck Institute for Global Health, University of Note Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferase E" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Jonas Weidenhausen
3 publications dans cette catégorie
Affiliations :
- Heidelberg University Biochemistry Center, 69120 Heidelberg, Germany.
Publications dans "N-terminal acetyltransferase E" :
-
Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Structure (London, England : 1993) 2021-01-04
-
Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.
International journal of molecular sciences 2022-09-16
-
HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana.
Cell reports 2024-02-15
Markus Wirtz
3 publications dans cette catégorie
Affiliations :
- Centre for Organismal Studies, Heidelberg University, 69120 Heidelberg, Germany.
Publications dans "N-terminal acetyltransferase E" :
-
Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Structure (London, England : 1993) 2021-01-04
-
Dual lysine and N-terminal acetyltransferases reveal the complexity underpinning protein acetylation.
Molecular systems biology
-
HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana.
Cell reports 2024-02-15
Irmgard Sinning
3 publications dans cette catégorie
Affiliations :
- Heidelberg University Biochemistry Center, 69120 Heidelberg, Germany. Electronic address: irmi.sinning@bzh.uni-heidelberg.de.
Publications dans "N-terminal acetyltransferase E" :
-
Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Structure (London, England : 1993) 2021-01-04
-
Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.
International journal of molecular sciences 2022-09-16
-
HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana.
Cell reports 2024-02-15
Sarah M Gardner
3 publications dans cette catégorie
Affiliations :
- Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Publications dans "N-terminal acetyltransferase E" :
-
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.
Journal of medicinal chemistry 2021-06-10
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
Costas Koufaris
3 publications dans cette catégorie
Affiliations :
- Epigenetics and Gene Regulation Laboratory, Department of Biological Sciences, University of Cyprus, Nicosia 2109, Cyprus.
- Cyprus Cancer Research Institute, Nicosia 2109, Cyprus.
Publications dans "N-terminal acetyltransferase E" :
-
Biochemical Characterisation of the Short Isoform of Histone N-Terminal Acetyltransferase NAA40.
Biomolecules 2024-09-02
-
N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours.
Cancers 2020-09-15
-
Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance.
Oncogene 2021-11-16
Yan Li
3 publications dans cette catégorie
Affiliations :
- College of Life Sciences, Capital Normal University, Beijing, 100048, China.
Publications dans "N-terminal acetyltransferase E" :
-
The N-terminal acetyltransferase Naa50 regulates tapetum degradation and pollen development in Arabidopsis.
Plant science : an international journal of experimental plant biology 2022-01-11
-
The N-Terminal Acetyltransferase Naa50 Regulates Arabidopsis Growth and Osmotic Stress Response.
Plant & cell physiology
-
N-Terminalized Ti
Small (Weinheim an der Bergstrasse, Germany) 2023-10-12
Rasmus Ree
3 publications dans cette catégorie
Affiliations :
- Department of Biomedicine, University of Bergen, 5020 Bergen, Norway.
Publications dans "N-terminal acetyltransferase E" :
-
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.
Molecular cell 2019-03-13
-
Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae.
Nature communications 2023-07-27
-
Mechanism of actin N-terminal acetylation.
Science advances 2020-04-08
Buyan Pan
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Pennsylvania, 231 South 34(th) Street, Philadelphia, PA 19104, USA.
Publications dans "N-terminal acetyltransferase E" :
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
bioRxiv : the preprint server for biology 2023-04-03
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
E James Petersson
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Pennsylvania, 231 South 34(th) Street, Philadelphia, PA 19104, USA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Publications dans "N-terminal acetyltransferase E" :
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
bioRxiv : the preprint server for biology 2023-04-03
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
Veronique Jonckheere
2 publications dans cette catégorie
Affiliations :
- Department of Biochemistry and Microbiology, Ghent University, K. L. Ledeganckstraat 35, 9000 Ghent, Belgium.
Publications dans "N-terminal acetyltransferase E" :
-
N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.
International journal of molecular sciences 2021-04-01
-
Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
The Journal of biological chemistry 2022-12-22
Sources (10000 au total)
Continuum finite element analysis generalizes
Fragility of trabecular bone (Tb) microstructure is increased in osteoporosis, which is associated with rapid bone loss and enhanced fracture-risk. Accurate assessment of Tb strength using...
Mechanism of scaphoid waist fracture: finite element analysis.
The mechanism of scaphoid waist fracture is not completely understood. We used finite element analysis to study the formation of scaphoid waist fractures. Clinical computed tomography scans of 12 wris...
Disease-Specific Finite element Analysis of the Foot and Ankle.
Finite-element analysis is a computational modeling technique that can be used to quantify parameters that are difficult or impossible to measure externally in a geometrically complex structure such a...
Finite Elements Analysis of Tooth-A Comparative Analysis of Multiple Failure Criteria.
Herein Finite elements analysis (FEA) study assesses the adequacy and accuracy of five failure criteria (Von Mises (VM), Tresca, maximum principal (S1), minimum principal (S3), and Hydrostatic pressur...
Biomechanical analysis of sandwich vertebrae in osteoporotic patients: finite element analysis.
The aim of this study was to investigate the biomechanical stress of sandwich vertebrae (SVs) and common adjacent vertebrae in different degrees of spinal mobility in daily life.... A finite element model of the spinal segment of T10-L2 was developed and validated. Simultaneously, T11 and L1 fractures were simulated, and a 6-ml bone cement was constructed in their center. Under t... The maximum von Mises stress of T10 in the M-T10 group was 30.68 MPa, 36.13 MPa, 34.27 MPa, 33.43 MPa, 26.86 MPa, and 27.70 MPa greater than the maximum stress value of T10 in the other groups in six ... We found that SVs did not always experience the highest stress. The most stressed vertebrae vary with the degree of curvature of the spine. Patients should be encouraged to avoid the same spinal curva...
Influence of different postballoon expansion procedures: A finite element analysis.
Postballoon expansion is considered as an appropriate procedure for adequate stent expansion for coronary bifurcation lesions. Two postballoon expansion procedures are currently recommended: proximal ... It is recognized that biomechanical factors influence the occurrence of Major Cardiovascular Adverse Events (MACE), which includes recurrent angina pectoris, acute myocardial infarction and coronary h... Based on the CT angiography (CTA) data of a patient diagnosed with coronary bifurcation lesions, a personalized coronary bifurcation lesion model was constructed, and the surgical procedure after two ... Both postexpansion procedures were successfully simulated. The malapposition rate during POT/side/POT was larger (1.2% vs. 0.42%) and stent occlusion at the SB opening from the cross-section perpendic... Numerical simulations provide a quantitative analysis to inform clinicians of the differences between preoperative planning and surgical procedures. Biomechanical analysis of the differences between t...
Finite element analysis of intraosseous distal radioulnar joint prosthesis.
Joint replacement is one of the options to retrieve the interosseous distal radioulnar joint (DRUJ) function. DRUJ prosthesis has recently been introduced clinically to treat DRUJ instability. This ar... CT images of a healthy 33 years old man were used to construct the three-dimensional geometry of the forearm bone. Then two models, a healthy foreman (Model A) and a damaged model with an inserted int... Maximum and minimum principal stresses were evaluated for bones in all conditions, and von Mises stress was considered for the prosthesis and fixing screws. In supination, the maximum stress in Model ... Our study indicates that the interosseous DRUJ prosthesis can perform the foreman's normal daily activities. This prosthesis provides the ability similar to a normal hand.... IV....
Biomechanical evaluation of percutaneous cement discoplasty by finite element analysis.
Percutaneous cement discoplasty (PCD) is a minimally invasive treatment for degenerative lumbar spine disease, but the relationship between decompression effect on the nerve root and different doses o... To investigate the indirect decompression effect of cement with different doses on nerve roots and the biomechanical changes on the spine during PCD using finite element analysis (FEA).... FEA was adapted to analyze the mechanical changes in the lumbar vertebrae before and after the application of PCD.CT scan images of adult males were utilized to establish a finite element model of the... The stress of the nerve root in model H was the largest. The nerve root stress in the model H2 was the smallest during flexion, extension, left bending, right bending, left rotation, and right rotatio... The nerve root stress increased after degeneration and decreased after intervertebral height recovery through cement injection, resulting in a significant indirect decompression effect.The stress of t...
Finite element analysis of malposition in bi-unicompartmental knee arthroplasty.
Bi-unicompartmental knee arthroplasty is a less invasive treatment than a total one, great advantage for the patient but more difficult for the surgeon because of the lower visibility during surgery; ... The geometries of the bones were acquired and uncemented fixed bearing metal-back UKAs virtually implanted in a finite elements environment. The lateral component was implanted in six different antero... Outcomes for 0° and - 3° configurations are acceptable, but the - 2° of slope configuration achieved the best ones in terms of stress on proximal tibia, load repartition, contact pressure distribution... Slight errors can happen during the surgery: performing the cut aiming to slightly posterior slopes during the surgery helps to minimize the chances of obtaining positive slopes that could lead to an ...