Urinary Metabolomics Profiles Associated to Bovine Meat Ingestion in Humans.
Acetylcarnitine
/ urine
Adult
Animals
Biomarkers
/ urine
Cattle
Chromatography, High Pressure Liquid
/ methods
Cooking
Eating
Female
Glutamine
/ analogs & derivatives
Healthy Volunteers
Humans
Male
Metabolome
Methylhistidines
/ urine
Nitrogen Isotopes
/ urine
Red Meat
Tandem Mass Spectrometry
/ methods
Urine
/ chemistry
UPLC-QTOF-MS
acute intervention study
meat
non-targeted metabolite profiling
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
05
10
2017
revised:
21
12
2017
pubmed:
23
2
2018
medline:
15
5
2019
entrez:
23
2
2018
Statut:
ppublish
Résumé
The impact of meat consumption on human health is widely examined in nutritional epidemiological studies, especially due to the connection between the consumption of red and processed meat and the risk of colon cancer. Food questionnaires do not assess the exposure to different methods of meat cooking. This study aimed to identify biomarkers of the acute ingestion of bovine meat cooked with two different processes. Non-targeted UPLC-MS metabolite profiling was done on urine samples obtained from 24 healthy volunteers before and 8 h after the ingestion of a single meal composed of intrinsically Meat ingestion led to the excretion of several nitrogen-containing compounds, but although a metabolic signature was detected for meat ingestion, the impact of the cooking process was not detectable at the level of urinary metabolic signature in our experimental conditions.
Identifiants
pubmed: 29468821
doi: 10.1002/mnfr.201700834
doi:
Substances chimiques
Biomarkers
0
Methylhistidines
0
Nitrogen Isotopes
0
Glutamine
0RH81L854J
Acetylcarnitine
6DH1W9VH8Q
phenylacetylglutamine
92358I79RG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1700834Informations de copyright
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.