Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase.

Antiprotozoal Agents / chemistry Arginase / antagonists & inhibitors Binding Sites Cinnamates / chemistry Inhibitory Concentration 50 Kinetics Leishmania / drug effects Molecular Docking Simulation Protein Structure, Tertiary Protozoan Proteins / antagonists & inhibitors
Leishmania amazonensis arginase inhibition enzyme kinetics molecular modeling natural products polyamines

Journal

Chemical biology & drug design
ISSN: 1747-0285
Titre abrégé: Chem Biol Drug Des
Pays: England
ID NLM: 101262549

Informations de publication

Date de publication:
02 2019
Historique:
received: 25 05 2018
revised: 16 08 2018
accepted: 26 08 2018
pubmed: 15 9 2018
medline: 15 11 2019
entrez: 15 9 2018
Statut: ppublish

Résumé

This study describes the activity of five natural hydroxycinnamic acids and derived compound: caffeic (1), rosmarinic (2), chlorogenic (3), and cryptochlorogenic (4), acids and isoverbascoside (5). All compounds inhibited Leishmania amazonensis arginase with IC

Identifiants

DOI: 10.1111/cbdd.13391 PMID: 30216691
pubmed: 30216691
doi: 10.1111/cbdd.13391
doi:

Substances chimiques

Antiprotozoal Agents 0
Cinnamates 0
Protozoan Proteins 0
cinnamic acid 140-10-3
Arginase EC 3.5.3.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

139-146

Informations de copyright

© 2018 John Wiley & Sons A/S.

Auteurs

Edson Roberto da Silva (ER)

Department of Veterinary Medicine, Universidade de São Paulo, Pirassununga, Brazil.
ORCID: 0000-0002-6246-4404

Simone Brogi (S)

European Research Centre for Drug Discovery and Development (NatSynDrugs), Department of Biotechnology, Chemistry, and Pharmacy, Università degli Studi di Siena via Aldo Moro 2, Siena, Italy.
ORCID: 0000-0001-9375-6242

Alessandro Grillo (A)

European Research Centre for Drug Discovery and Development (NatSynDrugs), Department of Biotechnology, Chemistry, and Pharmacy, Università degli Studi di Siena via Aldo Moro 2, Siena, Italy.

Giuseppe Campiani (G)

European Research Centre for Drug Discovery and Development (NatSynDrugs), Department of Biotechnology, Chemistry, and Pharmacy, Università degli Studi di Siena via Aldo Moro 2, Siena, Italy.

Sandra Gemma (S)

European Research Centre for Drug Discovery and Development (NatSynDrugs), Department of Biotechnology, Chemistry, and Pharmacy, Università degli Studi di Siena via Aldo Moro 2, Siena, Italy.

Paulo Cezar Vieira (PC)

Department of Chemistry, Universidade Federal de São Carlos, São Carlos, Brazil.

Claudia do Carmo Maquiaveli (CDC)

Universidade Anhembi Morumbi, São Paulo, Brazil.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Cinnamic acids derived compounds with...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Ureohydrolases › Arginase › Cinnamic acids derived compounds with...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Cinnamic acids derived compounds with...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Cinnamates › Cinnamic acids derived compounds with...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Concentration inhibitrice 50 › Cinnamic acids derived compounds with...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Cinnamic acids derived compounds with...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Leishmania › Cinnamic acids derived compounds with...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Cinnamic acids derived compounds with...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Cinnamic acids derived compounds with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de protozoaire › Cinnamic acids derived compounds with...