Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia.

Adult Autism Spectrum Disorder / genetics Autistic Disorder / genetics Basal Ganglia / pathology Brain / pathology Chromosome Deletion Chromosome Disorders / genetics Chromosome Duplication Chromosomes, Human, Pair 16 / genetics DNA Copy Number Variations / genetics Databases, Factual Female Globus Pallidus / pathology Humans Image Processing, Computer-Assisted / methods Intellectual Disability / genetics Magnetic Resonance Imaging / methods Male Middle Aged Neurodevelopmental Disorders / genetics Organ Size / genetics Putamen / pathology Schizophrenia / genetics

Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
03 2020
Historique:
received: 12 02 2018
accepted: 25 05 2018
revised: 02 05 2018
pubmed: 5 10 2018
medline: 15 1 2021
entrez: 5 10 2018
Statut: ppublish

Résumé

Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = -0.71 to -1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = -0.95, P = 0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P = 0.0032, 8.9 × 10

Identifiants

DOI: 10.1038/s41380-018-0118-1 PMID: 30283035 PMC: PMC7042770
pubmed: 30283035
doi: 10.1038/s41380-018-0118-1
pii: 10.1038/s41380-018-0118-1
pmc: PMC7042770
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

584-602

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH081802
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089995
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB005846
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB006841
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH078111
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB000840
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH083824
Pays : United States
Organisme : NIMH NIH HHS
ID : RC1 MH089257
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089951
Pays : United States
Organisme : NIMH NIH HHS
ID : K08 MH068540
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103472
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085772
Pays : United States
Organisme : NCRR NIH HHS
ID : P41 RR014075
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD050735
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR001066
Pays : United States
Organisme : NCRR NIH HHS
ID : P20 RR021938
Pays : United States
Organisme : NCRR NIH HHS
ID : U24 RR021992
Pays : United States

Commentaires et corrections

Type : ErratumIn

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Auteurs

Ida E Sønderby (IE)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Ómar Gústafsson (Ó)

deCODE Genetics/Amgen, Reykjavik, Iceland.

Nhat Trung Doan (NT)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Derrek P Hibar (DP)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, USA.
Janssen Research and Development, La Jolla, CA, USA.

Sandra Martin-Brevet (S)

Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.

Abdel Abdellaoui (A)

Biological Psychology, Vrije Universiteit Amsterdam, van Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.

David Ames (D)

National Ageing Research Institute, Melbourne, Australia.
Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia.

Katrin Amunts (K)

Institute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Wilhelm-Johnen-Str., 52425, Juelich, Germany.
C. and O. Vogt Institute for Brain Research, Medical Faculty, University of Dusseldorf, Merowingerplatz 1A, 40225, Dusseldorf, Germany.
JARA-BRAIN, Juelich-Aachen Research Alliance, Wilhelm-Johnen-Str., 52425, Juelich, Germany.

Michael Andersson (M)

Umeå Center for Functional Brain Imaging (UFBI), Umeå University, 90187, Umeå, Sweden.

Nicola J Armstrong (NJ)

Mathematics and Statistics, Murdoch University, Perth, Australia.

Manon Bernard (M)

The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, Canada.

Nicholas Blackburn (N)

South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, One West University Blvd., 78520, Brownsville, TX, USA.

John Blangero (J)

South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, One West University Blvd., 78520, Brownsville, TX, USA.

Dorret I Boomsma (DI)

Netherlands Twin Register, Vrije Universiteit, van der Boechorststraat 1, 1081BT, Amsterdam, Netherlands.

Janita Bralten (J)

Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.

Hans-Richard Brattbak (HR)

Department of Clinical Science, University of Bergen, Bergen, Norway.
Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.

Henry Brodaty (H)

Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, UNSW, Sydney, Australia.

Rachel M Brouwer (RM)

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

Robin Bülow (R)

Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.

Vince Calhoun (V)

The Mind Research Network, The University of New Mexico, Albuquerque, NM, Mexico.

Svenja Caspers (S)

Institute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Wilhelm-Johnen-Str., 52425, Juelich, Germany.
C. and O. Vogt Institute for Brain Research, Medical Faculty, University of Dusseldorf, Merowingerplatz 1A, 40225, Dusseldorf, Germany.
JARA-BRAIN, Juelich-Aachen Research Alliance, Wilhelm-Johnen-Str., 52425, Juelich, Germany.

Gianpiero Cavalleri (G)

The Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

Chi-Hua Chen (CH)

Department of Radiology, University of California San Diego, La Jolla, USA.
Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, USA.

Sven Cichon (S)

Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organisation of the Brain, Genomic Imaging, Research Centre Juelich, Leo-Brandt-Strasse 5, 52425, Jülich, Germany.
Human Genomics Research Group, Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland.
Institute of Medical Genetics and Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031, Basel, Switzerland.

Simone Ciufolini (S)

Psychosis Studies, Insitute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespingy Park, SE5 8AF, London, United Kingdom.

Aiden Corvin (A)

Neuropsychiatric Genetics Research Group, Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

Benedicto Crespo-Facorro (B)

Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, 39008, Santander, Spain.
CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, 39011, Spain.

Joanne E Curran (JE)

South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, One West University Blvd., 78520, Brownsville, TX, USA.

Anders M Dale (AM)

Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, USA.

Shareefa Dalvie (S)

Department of Psychiatry and Mental Health, Anzio Road, 7925, Cape Town, South Africa.

Paola Dazzan (P)

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, SE5 8AF, London, United Kingdom.
National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, United Kingdom.

Eco J C de Geus (EJC)

Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit, van der Boechorststraat 1, 1081 BT, Amsterdam, Netherlands.
Amsterdam Neuroscience, VU University medical center, van der Boechorststraat 1, 1081 BT, Amsterdam, NH, Netherlands.

Greig I de Zubicaray (GI)

Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.

Sonja M C de Zwarte (SMC)

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

Norman Delanty (N)

The Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.
Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, 4860 Y Street, Suite 3700, Sacramento, California, 95817, USA.

Anouk den Braber (A)

Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit, van der Boechorststraat 1, 1081 BT, Amsterdam, Netherlands.
Alzheimer Center and Department of Neurology, VU University Medical Center, De Boelelaan 1105, 1081HV, Amsterdam, Netherlands.

Sylvane Desrivières (S)

Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.

Gary Donohoe (G)

Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition & Genomics Centre (NICOG) & NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, H91 TK33, Galway, Ireland.
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 8, Ireland.

Bogdan Draganski (B)

LREN - Département des neurosciences cliniques, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Stefan Ehrlich (S)

Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, 01307, Dresden, Germany.
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA.
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, 02129, USA.

Thomas Espeseth (T)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Department of Psychology, University of Oslo, Oslo, Norway.

Simon E Fisher (SE)

Language and Genetics Department, Max Planck Institute for Psycholinguistics, Wundtlaan 1, 6525 XD, Nijmegen, Netherlands.
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.

Barbara Franke (B)

Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.

Vincent Frouin (V)

NeuroSpin, CEA, Université Paris-Saclay, F-91191, Gif-sur-Yvette, France.

Masaki Fukunaga (M)

Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, Japan.

Thomas Gareau (T)

NeuroSpin, CEA, Université Paris-Saclay, F-91191, Gif-sur-Yvette, France.

David C Glahn (DC)

Yale University School of Medicine, 40 Temple Street, Suite 6E, 6511, New Haven, Vaud, USA.
Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, 300 George Street, 6106, Hartford, CT, USA.

Hans Grabe (H)

Department of Psychiatry und Psychotherapy, University Medicine Greifswald, Greifswald, Germany.

Nynke A Groenewold (NA)

Department of Psychiatry and Mental Health, Anzio Road, 7925, Cape Town, South Africa.

Jan Haavik (J)

K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.

Asta Håberg (A)

Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Ryota Hashimoto (R)

Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan.

Jayne Y Hehir-Kwa (JY)

Princess Máxima Center for Pediatric Oncology, Lundlaan 6, 3584 EA, Utrecht, The Netherlands.

Andreas Heinz (A)

Dept. of Psychiatry and Psychotherapie, Charite, Humboldt University, Chariteplatz 1, 10017, Berlin, Germany.

Manon H J Hillegers (MHJ)

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Child and adolescent Psychiatry / Psychology, Erasmus medical center-Sophia's Childerens hospitaal, Rotterdam, Wytemaweg 8, 3000 CB, Rotterdam, The Netherlands.

Per Hoffmann (P)

Human Genomics Research Group, Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland.
Institute of Medical Genetics and Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031, Basel, Switzerland.
Institute of Human Genetics, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.

Laurena Holleran (L)

The Centre for Neuroimaging & Cognitive Genomics (NICOG) and NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland.

Jouke-Jan Hottenga (JJ)

Biological Psychology, Vrije Universiteit Amsterdam, van Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.

Hilleke E Hulshoff (HE)

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

Masashi Ikeda (M)

Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.

Neda Jahanshad (N)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, USA.

Terry Jernigan (T)

Center for Human Development, University of California San Diego, San Diego, CA, USA.

Christiane Jockwitz (C)

Institute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Wilhelm-Johnen-Str., 52425, Juelich, Germany.
JARA-BRAIN, Juelich-Aachen Research Alliance, Wilhelm-Johnen-Str., 52425, Juelich, Germany.
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Medical Faculty, Pauwelsstraße 30, 52074, Aachen, Germany.

Stefan Johansson (S)

Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.

Gudrun A Jonsdottir (GA)

deCODE Genetics/Amgen, Reykjavik, Iceland.

Erik G Jönsson (EG)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Karolinska University Hospital Solna, R5:00, SE-17176, Stockholm, Sweden.

Rene Kahn (R)

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

Tobias Kaufmann (T)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Sinead Kelly (S)

The Centre for Neuroimaging & Cognitive Genomics (NICOG) and NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland.

Masataka Kikuchi (M)

Department of Genome Informatics, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.

Emma E M Knowles (EEM)

Department of Psychiatry, Yale University, 40 Temple Street, 6515, New Haven, CT, USA.

Knut K Kolskår (KK)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Department of Psychology, University of Oslo, Oslo, Norway.
Sunnaas Rehabilitation Hospital HT, Nesodden, Norway.

John B Kwok (JB)

Brain and Mind Centre, University of Sydney, Sydney, Australia.

Stephanie Le Hellard (SL)

NORMENT - KG Jebsen Centre, Department of Clinical Science, University of Bergen, Jonas Lies veg 87, 5021, Bergen, Norway.
Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Jonas Lies veg 87, 5021, Bergen, Norway.

Costin Leu (C)

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Institute of Neurology, University College London, London, United Kingdom.

Jingyu Liu (J)

The Mind Research Network, 1101 Yale Blvd., 87106, Albuquerque, CT, USA.
Dept. of Electrical and Computer Engineering, University of New Mexico, 87131, Albuquerque, New Mexico, USA.

Astri J Lundervold (AJ)

K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
Department of Biological and Medical Psychology, Jonas Lies vei 91, N-5009, Bergen, Norway.

Arvid Lundervold (A)

Department of Biomedicine, University of Bergen, 5009, Bergen, Norway.

Nicholas G Martin (NG)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Karen Mather (K)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, 2052, Australia.

Samuel R Mathias (SR)

Department of Psychiatry, Yale University, 40 Temple Street, 6515, New Haven, CT, USA.

Mark McCormack (M)

Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St. Stephens Green, D02 YN77, Dublin, Ireland.
Centre for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, Netherlands.

Katie L McMahon (KL)

Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.

Allan McRae (A)

Program in Complex Trait Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia.

Yuri Milaneschi (Y)

Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands, Oldenaller 1, 1081 HJ, Amsterdam, The Netherlands.

Clara Moreau (C)

CHU Sainte-Justine Research Center, Université de Montréal, Montréal, QC, Canada.

Derek Morris (D)

Cognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition & Genomics Centre (NICOG) & NCBES Galway Neuroscience Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, H91 TK33, Galway, Ireland.
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 8, Ireland.

David Mothersill (D)

The Centre for Neuroimaging & Cognitive Genomics (NICOG) and NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland.

Thomas W Mühleisen (TW)

Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organisation of the Brain, Genomic Imaging, Research Centre Juelich, Leo-Brandt-Strasse 5, 52425, Jülich, Germany.
Human Genomics Research Group, Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland.

Robin Murray (R)

Departments of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.

Jan E Nordvik (JE)

Sunnaas Rehabilitation Hospital HT, Nesodden, Norway.

Lars Nyberg (L)

Umeå Center for Functional Brain Imaging (UFBI), Umeå University, 90187, Umeå, Sweden.

Loes M Olde Loohuis (LM)

Center for Neurobehavioral Genetics, University of California, Los Angeles, California, 90095, USA.

Roel Ophoff (R)

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Center for Neurobehavioral Genetics, University of California, Los Angeles, California, 90095, USA.

Tomas Paus (T)

Rotman Research Institute, University of Toronto, Toronto, M6A 2E1, Canada.
Department of Psychiatry, University of Toronto, Toronto, M5S 1A1, Canada.
Center for Developing Brain, Child Mind Institute, New York, NY, 10022, USA.
Department of Psychology, University of Toronto, Toronto, M5S 1A1, Canada.

Zdenka Pausova (Z)

The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, Canada.

Brenda Penninx (B)

Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical, Amsterdam, Netherlands.

Juan M Peralta (JM)

South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, One West University Blvd., 78520, Brownsville, TX, USA.

Bruce Pike (B)

Departments of Radiology & Clinical Neuroscience, University of Calgary, Calgary, T2N 1N4, Canada.

Carlos Prieto (C)

Bioinformatics Service, Nucleus, University of Salamanca (USAL), 37007, Salamanca, Spain.

Sara Pudas (S)

Umeå Center for Functional Brain Imaging (UFBI), Umeå University, 90187, Umeå, Sweden.
Department of Integrative Medical Biology, Linnéus väg 9, 901 87, Umeå, Sweden.

Erin Quinlan (E)

Centre for Population Neuroscience and Stratified Medicine, Social, Genetic and Development Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, London, UK.

Daniel S Quintana (DS)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Department of Psychology, University of Oslo, Oslo, Norway.

Céline S Reinbold (CS)

Human Genomics Research Group, Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland.
Institute of Medical Genetics and Pathology, University Hospital Basel, Schönbeinstrasse 40, 4031, Basel, Switzerland.

Tiago Reis Marques (TR)

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, SE5 8AF, London, United Kingdom.
Psychiatry Imaging Group, MRC London Institute of Medical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, W12 0NN, London, UK.

Alexandre Reymond (A)

Center for Integrative Genomics, University of Lausanne, Genopode building, CH-1015, Lausanne, Switzerland.

Genevieve Richard (G)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Department of Psychology, University of Oslo, Oslo, Norway.
Sunnaas Rehabilitation Hospital HT, Nesodden, Norway.

Borja Rodriguez-Herreros (B)

Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
CHU Sainte-Justine Research Center, Université de Montréal, Montréal, QC, Canada.

Roberto Roiz-Santiañez (R)

Department of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, 39008, Santander, Spain.
CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, 39011, Spain.

Jarek Rokicki (J)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

James Rucker (J)

National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, United Kingdom.
Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.

Perminder Sachdev (P)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, 2052, Australia.

Anne-Marthe Sanders (AM)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Department of Psychology, University of Oslo, Oslo, Norway.
Brain and Mind Centre, University of Sydney, Sydney, Australia.

Sigrid B Sando (SB)

Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Neurology, University Hospital of Trondheim, Edvard Griegs gate 8, N-7006, Trondheim, Norway.

Lianne Schmaal (L)

Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, 3502, Parkville, New Mexico, Australia.
Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, 3502, Parkville, Victoria, Australia.
Department of Psychiatry, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands.

Peter R Schofield (PR)

Neuroscience Research Australia, Randwick, Australia.
School of Medical Sciences, University of New South Wales, Sydney, Australia.

Andrew J Schork (AJ)

Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, USA.

Gunter Schumann (G)

Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.

Jean Shin (J)

The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, Canada.
Center for Neurobehavioral Genetics, University of California, Los Angeles, California, 90095, USA.

Elena Shumskaya (E)

Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.

Sanjay Sisodiya (S)

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Chalfont Centre for Epilepsy, London, UK.

Vidar M Steen (VM)

NORMENT - KG Jebsen Centre, Department of Clinical Science, University of Bergen, Jonas Lies veg 87, 5021, Bergen, Norway.
Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Jonas Lies veg 87, 5021, Bergen, Norway.

Dan J Stein (DJ)

Dept of Psychiatry, University of Cape Town, Groote Schuur Hospital, Anzio Rd, 7925, Cape Town, South Africa.
MRC Unit on Risk & Resilience in Mental Disorders, Stellenbosch, South Africa.

Stacy Steinberg (S)

deCODE Genetics/Amgen, Reykjavik, Iceland.

Lachlan Strike (L)

Queensland Brain Institute, University of Queensland, St Lucia, Queensland, Australia.

Alexander Teumer (A)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.

Anbu Thalamuthu (A)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, 2052, Australia.

Diana Tordesillas-Gutierrez (D)

CIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, 39011, Spain.
Neuroimaging Unit, Technological Facilities. Valdecilla Biomedical Research Institute IDIVAL, Santander, Cantabria, 39011, Spain.

Jessica Turner (J)

Department of Psychology, Georgia State University, Atlanta, GA, USA.

Torill Ueland (T)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Anne Uhlmann (A)

Department of Psychiatry and Mental Health, Anzio Road, 7925, Cape Town, South Africa.
Department of Psychiatry, Stellenbosch University, TBH Francie van Zijl Avenue, 7500, Cape Town, South Africa.
Department of Psychiatry, 1 South Prospect Street, 5401, Burlington, Vermont, USA.

Magnus O Ulfarsson (MO)

deCODE Genetics/Amgen, Reykjavik, Iceland.
Faculty of Electrical and Computer Engineering, University of Iceland, Reykjavik, Iceland.

Dennis van 't Ent (D)

Biological Psychology, Vrije Universiteit Amsterdam, van Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.

Dennis van der Meer (D)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Neeltje E M van Haren (NEM)

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

Anja Vaskinn (A)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Evangelos Vassos (E)

MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, London, UK.

G Bragi Walters (GB)

deCODE Genetics/Amgen, Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Yunpeng Wang (Y)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Wei Wen (W)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, 2052, Australia.

Christopher D Whelan (CD)

Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St. Stephens Green, D02 YN77, Dublin, Ireland.

Katharina Wittfeld (K)

German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, Greifswald, Germany.

Margie Wright (M)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Centre for Advanced Imaging, University of Queensland, St Lucia, Queensland, Australia.

Hidenaga Yamamori (H)

Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Tetyana Zayats (T)

K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
Department of Biomedicine, University of Bergen, 5009, Bergen, Norway.

Ingrid Agartz (I)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Lars T Westlye (LT)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Department of Psychology, University of Oslo, Oslo, Norway.
ORCID: 0000-0001-8644-956X

Sébastien Jacquemont (S)

CHU Sainte-Justine Research Center, Université de Montréal, Montréal, QC, Canada.
Department of Pediatrics, University of Montreal, Montreal, H3C 3J7, Canada.

Srdjan Djurovic (S)

NORMENT - KG Jebsen Centre, Department of Clinical Science, University of Bergen, Jonas Lies veg 87, 5021, Bergen, Norway.
Department of Medical Genetics, Oslo University Hospital, Kirkeveien 166, 424, Oslo, Norway.

Hreinn Stefánsson (H)

deCODE Genetics/Amgen, Reykjavik, Iceland.

Kári Stefánsson (K)

deCODE Genetics/Amgen, Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Paul Thompson (P)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, USA.

Ole A Andreassen (OA)

NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. andreassen@medisin.uio.no.
ORCID: 0000-0002-4461-3568

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Trouble autistique › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Phénomènes génétiques › Ploïdies › Aneuploïdie › Monosomie › Délétion de segment de chromosome › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies chromosomiques › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Duplication chromosomique › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes de mammifère › Chromosomes humains › Chromosomes humains 16-18 › Chromosomes humains de la paire 16 › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Variation structurale du génome › Variations de nombre de copies de segment d'ADN › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Bases de données comme sujet › Bases de données factuelles › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Globus pallidus › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Traitement d'image par ordinateur › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Déficience intellectuelle › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Taille d'organe › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Néostriatum › Putamen › Dose response of the 16p11.2 distal copy...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Dose response of the 16p11.2 distal copy...