A Diagnostic Algorithm To Investigate Pyrazinamide and Ethambutol Resistance in Rifampin-Resistant Mycobacterium tuberculosis Isolates in a Low-Incidence Setting.
Mycobacterium tuberculosis
ethambutol
pyrazinamide
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
23
08
2018
accepted:
31
10
2018
pubmed:
21
11
2018
medline:
28
1
2020
entrez:
21
11
2018
Statut:
epublish
Résumé
Phenotypic drug susceptibility testing (DST) for the two first-line tuberculosis drugs ethambutol and pyrazinamide is known to yield unreliable and inaccurate results. In this prospective study, we propose a diagnostic algorithm combining phenotypic DST with Sanger sequencing to inform clinical decision-making for drug-resistant
Identifiants
pubmed: 30455227
pii: AAC.01798-18
doi: 10.1128/AAC.01798-18
pmc: PMC6355586
pii:
doi:
Substances chimiques
Antitubercular Agents
0
Pyrazinamide
2KNI5N06TI
Ethambutol
8G167061QZ
Rifampin
VJT6J7R4TR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 Andres et al.
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