Second update of the International Registry of HLA Epitopes. I. The HLA-ABC Epitope Database.
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
15
08
2018
revised:
11
11
2018
accepted:
16
11
2018
pubmed:
21
11
2018
medline:
27
6
2019
entrez:
21
11
2018
Statut:
ppublish
Résumé
The International Registry of HLA Epitopes (http://www.epregistry.com.br) is a website-based resource for HLA epitopes important in transplant rejection and platelet transfusion refractoriness. Its primary goal is to document epitopes that are verified experimentally with specific antibodies. Such epitopes can be defined by single eplets and by eplets paired with certain polymorphic residues within a 15-Å radius, the dimension of the corresponding structural epitope. This report is an update of the HLA-ABC repertoire including descriptions of 72 antibody-verifications of epitopes defined by eplets and/or eplet pairs. The newly updated version 2.0 EpRegistry shows also the polymorphic residue compositions of structural epitopes corresponding to eplets shared between groups of alleles. At present, 151 eplets have not been antibody-verified, and we ranked them with a so-called ElliPro score as a potential predictor of immunogenicity. Sixty eplets with low ElliPro scores might be considered non-epitopes incapable of inducing specific antibodies.
Identifiants
pubmed: 30458204
pii: S0198-8859(18)30665-7
doi: 10.1016/j.humimm.2018.11.007
pii:
doi:
Substances chimiques
HLA Antigens
0
Immunodominant Epitopes
0
Isoantibodies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103-106Informations de copyright
Copyright © 2018. Published by Elsevier Inc.