A widespread alternative squalene epoxidase participates in eukaryote steroid biosynthesis.

Biosynthetic Pathways Coenzymes Diatoms / enzymology Eukaryota / classification Gene Expression Genetic Complementation Test Membrane Proteins / chemistry Mixed Function Oxygenases / chemistry Phylogeny Protein Conformation Saccharomyces cerevisiae / drug effects Squalene / analogs & derivatives Squalene Monooxygenase / chemistry Steroids / biosynthesis Terbinafine / pharmacology

Journal

Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869

Informations de publication

Date de publication:
02 2019
Historique:
received: 01 08 2018
accepted: 24 10 2018
pubmed: 28 11 2018
medline: 28 5 2019
entrez: 28 11 2018
Statut: ppublish

Résumé

Steroids are essential triterpenoid molecules that are present in all eukaryotes and modulate the fluidity and flexibility of cell membranes. Steroids also serve as signalling molecules that are crucial for growth, development and differentiation of multicellular organisms

Identifiants

DOI: 10.1038/s41564-018-0305-5 PMID: 30478288
pubmed: 30478288
doi: 10.1038/s41564-018-0305-5
pii: 10.1038/s41564-018-0305-5
doi:

Substances chimiques

2,3-oxidosqualene 0
Coenzymes 0
Membrane Proteins 0
Steroids 0
Squalene 7QWM220FJH
Mixed Function Oxygenases EC 1.-
Squalene Monooxygenase EC 1.14.14.17
Terbinafine G7RIW8S0XP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

226-233

Commentaires et corrections

Type : CommentIn

Auteurs

Jacob Pollier (J)

Ghent University, Department of Plant Biotechnology and Bioinformatics, Ghent, Belgium.
VIB Center for Plant Systems Biology, Ghent, Belgium.
ORCID: 0000-0002-1134-9238

Emmelien Vancaester (E)

Ghent University, Department of Plant Biotechnology and Bioinformatics, Ghent, Belgium.
VIB Center for Plant Systems Biology, Ghent, Belgium.
ORCID: 0000-0002-9177-8808

Unnikrishnan Kuzhiumparambil (U)

Climate Change Cluster, University of Technology Sydney, Ultimo, New South Wales, Australia.

Claudia E Vickers (CE)

CSIRO Synthetic Biology Future Science Platform, Brisbane, Queensland, Australia.
Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, Queensland, Australia.

Klaas Vandepoele (K)

Ghent University, Department of Plant Biotechnology and Bioinformatics, Ghent, Belgium.
VIB Center for Plant Systems Biology, Ghent, Belgium.

Alain Goossens (A)

Ghent University, Department of Plant Biotechnology and Bioinformatics, Ghent, Belgium. alain.goossens@psb.vib-ugent.be.
VIB Center for Plant Systems Biology, Ghent, Belgium. alain.goossens@psb.vib-ugent.be.
ORCID: 0000-0002-1599-551X

Michele Fabris (M)

Climate Change Cluster, University of Technology Sydney, Ultimo, New South Wales, Australia.
CSIRO Synthetic Biology Future Science Platform, Brisbane, Queensland, Australia.

Articles similaires

Comprehensive comparative analysis and development of molecular markers for Lasianthus species based on complete chloroplast genome sequences.

Yue Zhang, Meifang Song, Deying Tang et al.
1.00
Genome, Chloroplast Phylogeny Genetic Markers Base Composition High-Throughput Nucleotide Sequencing

Decoding the genomic terrain: functional insights into 14 chemosensory proteins in whitefly Bemisia tabaci Asia II-1.

M N Rudra Gouda, Sabtharishi Subramanian
1.00
Animals Hemiptera Insect Proteins Phylogeny Insecticides

Multiple NADPH-cytochrome P450 reductases from Lycoris radiata involved in Amaryllidaceae alkaloids biosynthesis.

Yuqing Wu, Yifeng Zhang, Haitong Fan et al.
1.00
Amaryllidaceae Alkaloids Lycoris NADPH-Ferrihemoprotein Reductase Gene Expression Regulation, Plant Plant Proteins

Systematical characterization of Rab7 gene family in Gossypium and potential functions of GhRab7B3-A gene in drought tolerance.

Mengyuan Yan, Zhiwei Dong, Tian Pan et al.
1.00
Drought Resistance Gene Expression Profiling Gene Expression Regulation, Plant Gossypium Multigene Family

Classifications MeSH

questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Voies de biosynthèse › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Enzymes et coenzymes › Coenzymes › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Eucaryotes › Straménopiles › Diatomées › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Eucaryotes › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Croisements génétiques › Test de complémentation › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Squalène › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Squalene monooxygenase › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › A widespread alternative squalene epoxidase...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Terbinafine › A widespread alternative squalene epoxidase...