HLA testing in the molecular diagnostic laboratory.
HLA
Immunogenetics
Molecular
SSO
SSP
Transplantation
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
20
07
2018
accepted:
27
11
2018
pubmed:
6
12
2018
medline:
21
3
2019
entrez:
6
12
2018
Statut:
ppublish
Résumé
The human leukocyte antigen (HLA) system is a highly polymorphic family of genes involved in immunity and responsible for identifying self versus non-self. HLA typing is essential for solid organ and bone marrow transplantation as well as in non-transplant settings such as disease association and pharmacogenomics. Typing of HLA genes differs from most molecular testing as, rather than evaluating differences from an accepted "wild-type" gene, it must distinguish between thousands of similar, but distinct alleles. This article will describe the HLA system and nomenclature. We will then discuss clinical uses of HLA typing including solid organ transplantation, hematopoietic stem cell transplantation, evaluation of platelet refractory patients, disease association, and pharmacogenetics. Finally, we describe common molecular methods of HLA typing.
Identifiants
pubmed: 30515565
doi: 10.1007/s00428-018-2501-3
pii: 10.1007/s00428-018-2501-3
doi:
Substances chimiques
HLA Antigens
0
Histocompatibility Antigens Class II
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
139-147Références
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