Translation of Small Open Reading Frames: Roles in Regulation and Evolutionary Innovation.
de novo protein
micropeptide
open reading frame
ribosome profiling
translatome
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
12
10
2018
accepted:
07
12
2018
pubmed:
5
1
2019
medline:
9
1
2020
entrez:
5
1
2019
Statut:
ppublish
Résumé
The translatome can be defined as the sum of the RNA sequences that are translated into proteins in the cell by the ribosomal machinery. Until recently, it was generally assumed that the translatome was essentially restricted to evolutionary conserved proteins encoded by the set of annotated protein-coding genes. However, it has become increasingly clear that it also includes small regulatory open reading frames (ORFs), functional micropeptides, de novo proteins, and the pervasive translation of likely nonfunctional proteins. Many of these ORFs have been discovered thanks to the development of ribosome profiling, a technique to sequence ribosome-protected RNA fragments. To fully capture the diversity of translated ORFs, we propose a comprehensive classification that includes the new types of translated ORFs in addition to standard proteins.
Identifiants
pubmed: 30606460
pii: S0168-9525(18)30222-1
doi: 10.1016/j.tig.2018.12.003
pii:
doi:
Substances chimiques
RNA
63231-63-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
186-198Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.