Identification of hydroxytyrosyl oleate, a derivative of hydroxytyrosol with anti-inflammatory properties, in olive oil by-products.

Animals Anti-Inflammatory Agents / chemistry Chromatography, High Pressure Liquid Cyclooxygenase 2 / genetics Dinoprostone / metabolism Down-Regulation / drug effects Lipopolysaccharides / pharmacology Macrophages / cytology Magnetic Resonance Spectroscopy Mice Nitric Oxide / metabolism Nitric Oxide Synthase Type II / genetics Oleic Acid / chemistry Olive Oil / chemistry Phenylethyl Alcohol / analogs & derivatives RAW 264.7 Cells Tandem Mass Spectrometry
COX-2 Hydroxytyrosyl ester Inflammation Macrophages NO Olive mill waste water Olive oil PGE(2)

Journal

Food chemistry
ISSN: 1873-7072
Titre abrégé: Food Chem
Pays: England
ID NLM: 7702639

Informations de publication

Date de publication:
01 May 2019
Historique:
received: 24 07 2018
revised: 16 11 2018
accepted: 04 12 2018
entrez: 7 1 2019
pubmed: 7 1 2019
medline: 14 2 2019
Statut: ppublish

Résumé

Hydroxytyrosyl esters with short, medium and long acyl chains were evaluated for their ability to reduce nitric oxide (NO) production by lipopolysaccharide-stimulated RAW264.7 macrophages. Among the compounds tested, C18 esters, namely hydroxytyrosyl stearate (HtySte) and hydroxytyrosyl oleate (HtyOle), were found to decrease NO production in a concentration-dependent manner, while the other compounds, including the parent hydroxytyrosol, were ineffective in the tested concentration range (0.5-5 μM). Further study of the potential immune-modulating properties of HtyOle revealed a significant and concentration-dependent suppression of prostaglandin E

Identifiants

DOI: 10.1016/j.foodchem.2018.12.007 PMID: 30611468
pubmed: 30611468
pii: S0308-8146(18)32101-0
doi: 10.1016/j.foodchem.2018.12.007
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Lipopolysaccharides 0
Olive Oil 0
3,4-dihydroxyphenylethanol 10597-60-1
Oleic Acid 2UMI9U37CP
Nitric Oxide 31C4KY9ESH
Nitric Oxide Synthase Type II EC 1.14.13.39
Cyclooxygenase 2 EC 1.14.99.1
Dinoprostone K7Q1JQR04M
Phenylethyl Alcohol ML9LGA7468

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105-113

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Pierluigi Plastina (P)

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, CS, Italy. Electronic address: pierluigi.plastina@unical.it.

Cinzia Benincasa (C)

CREA - Research Centre for Olive, Citrus and Tree Fruit, C.da Li Rocchi, 87036 Rende, CS, Italy.

Enzo Perri (E)

CREA - Research Centre for Olive, Citrus and Tree Fruit, C.da Li Rocchi, 87036 Rende, CS, Italy.

Alessia Fazio (A)

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, CS, Italy.

Giuseppina Augimeri (G)

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, CS, Italy; Health Center, University of Calabria, 87036 Arcavacata di Rende, CS, Italy.

Mieke Poland (M)

Division of Human Nutrition and Health, Wageningen University, 6700 AA Wageningen, The Netherlands.

Renger Witkamp (R)

Division of Human Nutrition and Health, Wageningen University, 6700 AA Wageningen, The Netherlands.

Jocelijn Meijerink (J)

Division of Human Nutrition and Health, Wageningen University, 6700 AA Wageningen, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Cyclooxygenase 2 › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines E › Dinoprostone › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Nitric oxide synthase type II › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras monoinsaturés › Acides oléiques › Acide oléique › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Aliments et boissons › Aliments › Matières grasses alimentaires › Matières grasses alimentaires insaturées › Huile d'olive › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Alcool phénéthylique › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › Identification of hydroxytyrosyl oleate, a...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Identification of hydroxytyrosyl oleate, a...