Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection.
3T3-L1 Cells
Adipocytes
/ drug effects
Amino Acyl-tRNA Synthetases
/ metabolism
Animals
Cyclin-Dependent Kinase 5
/ metabolism
Enzyme Activation
HEK293 Cells
Hep G2 Cells
Humans
Insulin
/ pharmacology
Interferon-gamma
/ pharmacology
Lipid Metabolism
/ drug effects
Mechanistic Target of Rapamycin Complex 1
/ metabolism
Mice
Myeloid Cells
/ drug effects
Phosphorylation
Protein Processing, Post-Translational
Proteomics
/ methods
Ribosomal Protein S6 Kinases, 70-kDa
/ genetics
Ribosomal Protein S6 Kinases, 90-kDa
/ genetics
Signal Transduction
Substrate Specificity
U937 Cells
CdK 5
EPRS
S6K1
adipocyte
coenzyme A synthase
cortactin
insulin
lipocalin-2
mTORC1
phosphocode
Journal
Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571
Informations de publication
Date de publication:
07 02 2019
07 02 2019
Historique:
received:
21
05
2018
revised:
16
10
2018
accepted:
15
11
2018
pubmed:
8
1
2019
medline:
31
5
2019
entrez:
8
1
2019
Statut:
ppublish
Résumé
Multisite phosphorylation of kinases can induce on-off or graded regulation of catalytic activity; however, its influence on substrate specificity remains unclear. Here, we show that multisite phosphorylation of ribosomal protein S6 kinase 1 (S6K1) alters target selection. Agonist-inducible phosphorylation of glutamyl-prolyl tRNA synthetase (EPRS) by S6K1 in monocytes and adipocytes requires not only canonical phosphorylation at Thr
Identifiants
pubmed: 30612880
pii: S1097-2765(18)30987-0
doi: 10.1016/j.molcel.2018.11.017
pmc: PMC6415305
mid: NIHMS1517579
pii:
doi:
Substances chimiques
Insulin
0
Interferon-gamma
82115-62-6
Cyclin-Dependent Kinase 5
EC 2.7.11.1
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Ribosomal Protein S6 Kinases, 70-kDa
EC 2.7.11.1
Ribosomal Protein S6 Kinases, 90-kDa
EC 2.7.11.1
Rps6ka1 protein, mouse
EC 2.7.11.1
ribosomal protein S6 kinase, 70kD, polypeptide 1
EC 2.7.11.1
CDK5 protein, human
EC 2.7.11.22
Cdk5 protein, mouse
EC 2.7.11.22
Amino Acyl-tRNA Synthetases
EC 6.1.1.-
glutamyl-prolyl-tRNA synthetase
EC 6.1.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
446-457.e6Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL029582
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL076491
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM086430
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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