Characterization of l-Carnitine Metabolism in Sinorhizobium meliloti.

Aerobiosis Betaine / analogs & derivatives Biotransformation Carnitine / metabolism Metabolic Networks and Pathways / genetics Metabolomics Multigene Family Sinorhizobium meliloti / genetics
l-carnitine LC-MS bacterial metabolism enzymology functional genomics metabolomics orbitrap trimethylammonium compounds

Journal

Journal of bacteriology
ISSN: 1098-5530
Titre abrégé: J Bacteriol
Pays: United States
ID NLM: 2985120R

Informations de publication

Date de publication:
01 04 2019
Historique:
received: 12 12 2018
accepted: 15 01 2019
pubmed: 24 1 2019
medline: 18 12 2019
entrez: 24 1 2019
Statut: epublish

Résumé

l-Carnitine is a trimethylammonium compound mostly known for its contribution to fatty acid transport into mitochondria. In bacteria, it is synthesized from γ-butyrobetaine (GBB) and can be used as a carbon source. l-Carnitine can be formed directly by GBB hydroxylation or synthesized via a biosynthetic route analogous to fatty acid degradation. However, this multistep pathway has not been experimentally characterized. In this work, we identified by gene context analysis a cluster of l-carnitine anabolic genes next to those involved in its catabolism and proceeded to the complete

Identifiants

DOI: 10.1128/JB.00772-18 PMID: 30670548 PMC: PMC6416908
pubmed: 30670548
pii: JB.00772-18
doi: 10.1128/JB.00772-18
pmc: PMC6416908
pii:
doi:

Substances chimiques

Betaine 3SCV180C9W
gamma-butyrobetaine 407-64-7
Carnitine S7UI8SM58A

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 American Society for Microbiology.

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Auteurs

Pascal Bazire (P)

Génomique métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, Evry, France.

Nadia Perchat (N)

Génomique métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, Evry, France.

Ekaterina Darii (E)

Génomique métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, Evry, France.

Christophe Lechaplais (C)

Génomique métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, Evry, France.

Marcel Salanoubat (M)

Génomique métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, Evry, France.

Alain Perret (A)

Génomique métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, Evry, France aperret@genoscope.cns.fr.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Aérobiose › Characterization of l-Carnitine Metabolism in...
questionsmedicales.fr › Composés chimiques organiques › Composés onium › Composés d'ammonium quaternaire › Bétaïne › Characterization of l-Carnitine Metabolism in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biotransformation › Characterization of l-Carnitine Metabolism in...
questionsmedicales.fr › Composés chimiques organiques › Amines › Composés de triméthyl-ammonium › Carnitine › Characterization of l-Carnitine Metabolism in...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Characterization of l-Carnitine Metabolism in...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Characterization of l-Carnitine Metabolism in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Famille multigénique › Characterization of l-Carnitine Metabolism in...
questionsmedicales.fr › Bactéries › Proteobacteria › Alphaproteobacteria › Rhizobiaceae › Sinorhizobium › Sinorhizobium meliloti › Characterization of l-Carnitine Metabolism in...