Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing⁻Remitting Multiple Sclerosis.
Adult
Case-Control Studies
Female
Humans
Kynurenine
/ metabolism
Male
Metabolome
Middle Aged
Multiple Sclerosis, Chronic Progressive
/ cerebrospinal fluid
Multiple Sclerosis, Relapsing-Remitting
/ cerebrospinal fluid
Phenylalanine
/ metabolism
Pyrimidines
/ metabolism
Serotonin
/ metabolism
Tryptophan
/ metabolism
cerebrospinal fluid
mass spectrometry
metabolomics
multiple sclerosis
pyrimidine
tryptophan
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
24 01 2019
24 01 2019
Historique:
received:
14
12
2018
revised:
16
01
2019
accepted:
22
01
2019
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
27
1
2019
Statut:
epublish
Résumé
To better understand the pathophysiological differences between secondary progressive multiple sclerosis (SPMS) and relapsing-remitting multiple sclerosis (RRMS), and to identify potential biomarkers of disease progression, we applied high-resolution mass spectrometry (HRMS) to investigate the metabolome of cerebrospinal fluid (CSF). The biochemical differences were determined using partial least squares discriminant analysis (PLS-DA) and connected to biochemical pathways as well as associated to clinical and radiological measures. Tryptophan metabolism was significantly altered, with perturbed levels of kynurenate, 5-hydroxytryptophan, 5-hydroxyindoleacetate, and
Identifiants
pubmed: 30678351
pii: cells8020084
doi: 10.3390/cells8020084
pmc: PMC6406712
pii:
doi:
Substances chimiques
Pyrimidines
0
Serotonin
333DO1RDJY
Kynurenine
343-65-7
Phenylalanine
47E5O17Y3R
Tryptophan
8DUH1N11BX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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