Small open reading frames and cellular stress responses.
Journal
Molecular omics
ISSN: 2515-4184
Titre abrégé: Mol Omics
Pays: England
ID NLM: 101713384
Informations de publication
Date de publication:
01 04 2019
01 04 2019
Historique:
pubmed:
28
2
2019
medline:
30
7
2019
entrez:
28
2
2019
Statut:
ppublish
Résumé
Small open reading frames (smORFs) encoding polypeptides of less than 100 amino acids in eukaryotes (50 amino acids in prokaryotes) were historically excluded from genome annotation. However, recent advances in genomics, ribosome footprinting, and proteomics have revealed thousands of translated smORFs in genomes spanning evolutionary space. These smORFs can encode functional polypeptides, or act as cis-translational regulators. Herein we review evidence that some smORF-encoded polypeptides (SEPs) participate in stress responses in both prokaryotes and eukaryotes, and that some upstream ORFs (uORFs) regulate stress-responsive translation of downstream cistrons in eukaryotic cells. These studies provide insight into a regulated subclass of smORFs and suggest that at least some SEPs may participate in maintenance of cellular homeostasis under stress.
Identifiants
pubmed: 30810554
doi: 10.1039/c8mo00283e
pmc: PMC6662920
mid: NIHMS1014944
doi:
Substances chimiques
Peptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Pagination
108-116Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM122984
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM067543
Pays : United States
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