Renal medullary carcinomas depend upon
Alleles
Animals
CRISPR-Cas Systems
Carcinoma, Medullary
/ drug therapy
Cell Cycle
Cell Line, Tumor
Exome
Female
Humans
In Situ Hybridization, Fluorescence
Kidney
/ metabolism
Kidney Neoplasms
/ drug therapy
Mice
Mice, Nude
Mutation
Neoplasm Transplantation
Proteasome Endopeptidase Complex
/ genetics
Proteasome Inhibitors
/ pharmacology
RNA Interference
SMARCB1 Protein
/ genetics
Sequence Analysis, RNA
Ubiquitin
/ chemistry
Whole Genome Sequencing
MLN2238
SMARCB1
cancer biology
cell cycle
human
human biology
medicine
renal medullary carcinoma
ubiquitin-proteasome system
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
12 03 2019
12 03 2019
Historique:
received:
05
12
2018
accepted:
03
03
2019
pubmed:
13
3
2019
medline:
21
4
2020
entrez:
13
3
2019
Statut:
epublish
Résumé
Renal medullary carcinoma (RMC) is a rare and deadly kidney cancer in patients of African descent with sickle cell trait. We have developed faithful patient-derived RMC models and using whole-genome sequencing, we identified loss-of-function intronic fusion events in one
Identifiants
pubmed: 30860482
doi: 10.7554/eLife.44161
pii: 44161
pmc: PMC6436895
doi:
pii:
Substances chimiques
Proteasome Inhibitors
0
SMARCB1 Protein
0
SMARCB1 protein, human
0
Ubiquitin
0
Proteasome Endopeptidase Complex
EC 3.4.25.1
Banques de données
GEO
['GSE111787', 'GSE64019', 'GSE70421', 'GSE70678', 'GSE36133', 'GSE94321']
dbGaP
['phs001800.v1.p1']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : American Cancer Society
ID : 132943-MRSG-18-202-01-TBG
Pays : International
Organisme : NCI NIH HHS
ID : T32 CA136432
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007226
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD052896
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA101942
Pays : United States
Organisme : CureSearch for Children's Cancer
ID : 328545
Pays : International
Organisme : Alex's Lemonade Stand Foundation for Childhood Cancer
ID : Young Investigator Award
Pays : International
Organisme : U.S. Department of Defense
ID : W81XWH-15-1-0659
Pays : International
Organisme : NCI NIH HHS
ID : U01 CA176058
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA188073
Pays : United States
Organisme : Dana-Farber Cancer Institute
ID : Wong Family Award
Pays : International
Organisme : American Association for Cancer Research
ID : 14-40-31-HONG
Pays : International
Organisme : Boston Children's Hospital
ID : OFD BTREC CDA
Pays : International
Organisme : NCI NIH HHS
ID : U01 CA217848
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG002295
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007753
Pays : United States
Informations de copyright
© 2019, Hong et al.
Déclaration de conflit d'intérêts
AH, YT, JW, WK, BK, MD, GK, GS, TH, JL, XY, MT, MG, AS, RD, AW, BM, KL, PK, AT, CC, CC, AC, BC, KJ, BV, DS, OG, SS, DR, PG, SC, EM, CR, KL, JB No competing interests declared, PB, RB is a consultant for Novartis (Cambridge, MA), PC is an adviser for Pfizer, Inc (Groton, CT), CK is a Scientific Founder, member of the Board of Director, Scientific Advisory Board member, Shareholder, and Consultant for Foghorn Therapeutics, Inc (Cambridge, MA). Disclosure information for CK is also found at: http://www.kadochlab.org, WH is a consultant for Thermo Fisher, Aju IB, MPM Capital and Paraxel. W.C.H. is a founder and shareholder and serves on the scientific advisory board of KSQ Therapeutics
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