Functionally Related Genes Cluster into Genomic Regions That Coordinate Transcription at a Distance in Saccharomyces cerevisiae.
Saccharomyces cerevisiae
coregulation
gene expression
genomics
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
13 03 2019
13 03 2019
Historique:
entrez:
15
3
2019
pubmed:
15
3
2019
medline:
21
5
2019
Statut:
epublish
Résumé
Balancing gene expression is a fundamental challenge of all cell types. To properly regulate transcription on a genome-wide level, there are myriad mechanisms employed by the cell. One layer to this regulation is through spatial positioning, with particular chromosomal loci exerting an influence on transcription throughout a region. Many coregulated gene families utilize spatial positioning to coordinate transcription, with functionally related genes clustering together which can allow coordinated expression via adjacent gene coregulation. The mechanisms underlying this process have not been elucidated, though there are many coregulated gene families that exhibit this genomic distribution. In the present study, we tested for a role for the enhancer-promoter (EP) hypothesis, which demonstrates that regulatory elements can exert transcriptional effects over a broad distance, in coordinating transcriptional coregulation using budding yeast,
Identifiants
pubmed: 30867326
pii: 4/2/e00063-19
doi: 10.1128/mSphere.00063-19
pmc: PMC6416364
pii:
doi:
Substances chimiques
Heat-Shock Proteins
0
Ribosomal Proteins
0
Transcription Factors
0
Nitrogen
N762921K75
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 Cera et al.
Références
Genes Dev. 2011 Jan 1;25(1):29-40
pubmed: 21156811
Nat Genet. 2000 Oct;26(2):183-6
pubmed: 11017073
Genes Dev. 2014 Apr 1;28(7):672-82
pubmed: 24696452
Mol Syst Biol. 2010 Nov 30;6:435
pubmed: 21119629
Eukaryot Cell. 2014 Jun;13(6):738-48
pubmed: 24706020
Transcription. 2017 Aug 8;8(4):254-260
pubmed: 28448767
Nat Commun. 2011 Aug 16;2:433
pubmed: 21847107
Hum Genomics. 2017 Dec 21;11(1):35
pubmed: 29268782
Mol Biol Cell. 2000 Dec;11(12):4241-57
pubmed: 11102521
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Nature. 2004 Jun 3;429(6991):571-4
pubmed: 15175754
Annu Rev Genet. 2012;46:43-68
pubmed: 22934649
Mol Cell Biol. 2007 Aug;27(15):5575-86
pubmed: 17526727
Mol Cell. 2011 May 20;42(4):536-49
pubmed: 21596317
Cell. 2012 Aug 3;150(3):549-62
pubmed: 22863008
Genetics. 2015 Oct;201(2):599-612
pubmed: 26281848
Cold Spring Harb Perspect Biol. 2013 Aug 01;5(8):a017780
pubmed: 23906716
Biotechnol Biofuels. 2017 Jul 18;10:189
pubmed: 28729884
Nucleic Acids Res. 2016 Mar 18;44(5):e50
pubmed: 26602688
BMC Genomics. 2007 Jan 22;8:25
pubmed: 17241460
Nat Methods. 2012 Feb 05;9(4):373-8
pubmed: 22306811
Transcription. 2011 Mar;2(2):71-77
pubmed: 21468232
Int J Mol Sci. 2009 Aug 21;10(8):3658-70
pubmed: 20111688
Curr Opin Genet Dev. 2017 Apr;43:73-81
pubmed: 28110180
Eukaryot Cell. 2011 Jan;10(1):43-53
pubmed: 21115740
Cell. 1990 Nov 16;63(4):751-62
pubmed: 2225075
Genome Res. 2004 Jun;14(6):1060-7
pubmed: 15173112
Gene. 2003 Aug 14;313:17-42
pubmed: 12957375
Cell. 2013 Feb 14;152(4):685-9
pubmed: 23375745
Nat Rev Genet. 2014 Apr;15(4):272-86
pubmed: 24614317
Nat Cell Biol. 2008 Sep;10(9):1106-13
pubmed: 19160492
Genes Dev. 2005 Nov 15;19(22):2695-704
pubmed: 16291644
J Biol. 2002;1(1):5
pubmed: 12144710
Nat Rev Mol Cell Biol. 2015 Mar;16(3):178-89
pubmed: 25650798
Trends Genet. 2014 Jun;30(6):211-9
pubmed: 24774859
Mol Cell Biol. 2001 Dec;21(24):8638-50
pubmed: 11713296
mSphere. 2018 Jun 13;3(3):
pubmed: 29898982
Curr Opin Cell Biol. 2009 Dec;21(6):855-63
pubmed: 19796927
Mol Biol Cell. 1998 Dec;9(12):3273-97
pubmed: 9843569
Cell. 2015 Aug 27;162(5):948-59
pubmed: 26317464
G3 (Bethesda). 2016 Dec 7;6(12):4167-4174
pubmed: 27799341
BMC Genomics. 2012 Oct 10;13:546
pubmed: 23051624
Yeast. 2006 Mar;23(4):293-306
pubmed: 16544271