SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival: an epigenomic-smoking interaction analysis.
Adenocarcinoma of Lung
Aged
DNA Methylation
DNA, Neoplasm
/ genetics
Disease-Free Survival
Epigenomics
Female
GTPase-Activating Proteins
/ genetics
Genome-Wide Association Study
Humans
Lung Neoplasms
/ genetics
Male
Middle Aged
Neoplasm Proteins
/ genetics
Smoking
/ genetics
Smoking Cessation
Survival Rate
DNA methylation
interaction analysis
molecular cancer epidemiology
non-small-cell lung cancer
overall survival
smoking cessation
Journal
Molecular oncology
ISSN: 1878-0261
Titre abrégé: Mol Oncol
Pays: United States
ID NLM: 101308230
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
15
11
2018
revised:
13
03
2019
accepted:
18
03
2019
pubmed:
30
3
2019
medline:
23
4
2020
entrez:
30
3
2019
Statut:
ppublish
Résumé
Smoking cessation prolongs survival and decreases mortality of patients with non-small-cell lung cancer (NSCLC). In addition, epigenetic alterations of some genes are associated with survival. However, potential interactions between smoking cessation and epigenetics have not been assessed. Here, we conducted an epigenome-wide interaction analysis between DNA methylation and smoking cessation on NSCLC survival. We used a two-stage study design to identify DNA methylation-smoking cessation interactions that affect overall survival for early-stage NSCLC. The discovery phase contained NSCLC patients from Harvard, Spain, Norway, and Sweden. A histology-stratified Cox proportional hazards model adjusted for age, sex, clinical stage, and study center was used to test DNA methylation-smoking cessation interaction terms. Interactions with false discovery rate-q ≤ 0.05 were further confirmed in a validation phase using The Cancer Genome Atlas database. Histology-specific interactions were identified by stratification analysis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) patients. We identified one CpG probe (cg02268510
Identifiants
pubmed: 30924596
doi: 10.1002/1878-0261.12482
pmc: PMC6487703
doi:
Substances chimiques
DNA, Neoplasm
0
GTPase-Activating Proteins
0
Neoplasm Proteins
0
signal-induced proliferation-associated 1-like protein 3, human
0
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1235-1248Subventions
Organisme : NCI NIH HHS
ID : R01 CA092824
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197449
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES000002
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA209414
Pays : United States
Informations de copyright
© 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
Références
Annu Rev Public Health. 1997;18:83-104
pubmed: 9143713
Melanoma Res. 1996 Oct;6(5):379-85
pubmed: 8908598
Epigenetics. 2013 Mar;8(3):333-46
pubmed: 23422812
Clin Cancer Res. 2005 Sep 15;11(18):6442-9
pubmed: 16166418
Blood Cancer J. 2014 Mar 28;4:e198
pubmed: 24681962
Biochem Biophys Res Commun. 2018 Feb 26;497(1):115-121
pubmed: 29421659
Carcinogenesis. 2005 Jul;26(7):1182-95
pubmed: 15790591
Nat Cell Biol. 2010 Aug;12(8):758-67
pubmed: 20622870
Mol Oncol. 2018 Jun;12(6):913-924
pubmed: 29656435
Epigenetics. 2019 Feb;14(2):118-129
pubmed: 30665327
Nature. 2004 May 27;429(6990):457-63
pubmed: 15164071
Cell Immunol. 2010;261(1):1-8
pubmed: 19969290
J Cell Sci. 2007 Jan 1;120(Pt 1):17-22
pubmed: 17182900
Bioinformatics. 2015 Nov 1;31(21):3401-5
pubmed: 26112293
Oncogene. 2011 Apr 7;30(14):1615-30
pubmed: 21170083
Carcinogenesis. 2002 Sep;23(9):1511-8
pubmed: 12189195
Nat Rev Cancer. 2004 Feb;4(2):143-53
pubmed: 14732866
Med Oncol. 2015 Jan;32(1):339
pubmed: 25429831
Br J Cancer. 2017 Oct 10;117(8):1224-1232
pubmed: 28898236
Crit Rev Oncog. 2011;16(1-2):129-40
pubmed: 22150313
Nat Commun. 2015 Dec 04;6:8971
pubmed: 26634437
Hum Genomics. 2015 Jul 28;9:17
pubmed: 26216216
Clin Cancer Res. 2014 Dec 1;20(23):6127-40
pubmed: 25278450
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5357-61
pubmed: 9560280
Front Genet. 2013 Jul 17;4:132
pubmed: 23882278
Chest. 2006 Dec;130(6):1784-90
pubmed: 17166997
Cancer Res. 2003 Oct 1;63(19):6556-62
pubmed: 14559851
BMJ. 2010 Jan 21;340:b5569
pubmed: 20093278
Biochem Biophys Res Commun. 2017 Apr 8;485(3):693-697
pubmed: 28237701
Genome Biol. 2017 Jan 25;18(1):17
pubmed: 28122605
Int J Environ Res Public Health. 2013 Aug 27;10(9):3886-907
pubmed: 23985773
Cancer Biol Med. 2017 Feb;14(1):90-99
pubmed: 28443208
Nature. 2001 Jun 28;411(6841):1065-8
pubmed: 11429608
Clin Epigenetics. 2015 Jan 22;7:6
pubmed: 25663950
Nature. 2002 Mar 14;416(6877):190-4
pubmed: 11894097
Cell Cycle. 2010 Oct 1;9(19):3880-3
pubmed: 20890116
Biochim Biophys Acta. 2013 May;1830(5):3217-66
pubmed: 23036594
Eur J Cardiothorac Surg. 2011 Dec;40(6):1432-7; discussion 1437-8
pubmed: 21498082
Cell Signal. 2011 Sep;23(9):1479-88
pubmed: 21596132
Cancer. 2012 Jun 15;118(12):3153-64
pubmed: 22271645
Nat Rev Cancer. 2017 Aug 24;17(9):513-527
pubmed: 28835720
Cancer. 2016 Jul 15;122(14):2168-77
pubmed: 27142338
Cell Signal. 2016 Nov;28(11):1663-72
pubmed: 27495875
Nature. 2013 Jun 27;498(7455):S10-1
pubmed: 23803942
Blood. 2011 Jun 16;117(24):6425-37
pubmed: 21422471
J Tradit Complement Med. 2015 Jan 09;5(2):100-5
pubmed: 26151019
Hum Mol Genet. 2012 Jul 1;21(13):3073-82
pubmed: 22492999
Addiction. 2004 Jan;99(1):29-38
pubmed: 14678060
Mol Oncol. 2016 Feb;10(2):330-43
pubmed: 26601720
Lung Cancer. 2005 Mar;47(3):351-9
pubmed: 15713518
Hum Hered. 2016;81(1):26-34
pubmed: 27490128
Cell Physiol Biochem. 2017;44(2):532-553
pubmed: 29145191
Trends Genet. 2007 Aug;23(8):413-8
pubmed: 17559965
Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2370-7
pubmed: 17132767
Cardiovasc Toxicol. 2006;6(1):39-50
pubmed: 16845181
J Clin Oncol. 2013 Nov 10;31(32):4140-7
pubmed: 24081945
Ann Oncol. 2014 Aug;25(8):1475-84
pubmed: 24669016
Nature. 2007 May 24;447(7143):396-8
pubmed: 17522671
Proc Am Thorac Soc. 2008 Dec 1;5(8):811-5
pubmed: 19017734
CA Cancer J Clin. 2017 Jan;67(1):7-30
pubmed: 28055103
Clin Exp Metastasis. 2013 Dec;30(8):977-92
pubmed: 23793925
Cancer Epidemiol Biomarkers Prev. 2018 Dec;27(12):1527-1535
pubmed: 30185536
Epigenetics. 2013 Feb;8(2):203-9
pubmed: 23314698
Nat Rev Clin Oncol. 2015 Oct;12(10):584-96
pubmed: 26122183
Clin Epigenetics. 2018 Apr 2;10:41
pubmed: 29619118
Cancer Prev Res (Phila). 2016 Feb;9(2):189-95
pubmed: 26645279
Nature. 2015 Jan 15;517(7534):321-6
pubmed: 25592537
J Immunol. 2004 Jul 15;173(2):920-31
pubmed: 15240679