Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration.
Animals
Docosahexaenoic Acids
/ immunology
Gene Expression
/ drug effects
Gene Expression Profiling
Gene Ontology
High-Throughput Nucleotide Sequencing
Inflammation Mediators
/ immunology
Lipid Metabolism
/ immunology
Lipids
/ analysis
Macrophages
/ drug effects
Male
Mice, Inbred C57BL
Muscle, Skeletal
/ immunology
Regeneration
/ genetics
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
10
05
2018
accepted:
20
02
2019
pubmed:
3
4
2019
medline:
30
4
2019
entrez:
3
4
2019
Statut:
ppublish
Résumé
Muscle damage elicits a sterile immune response that facilitates complete regeneration. Here, we used mass spectrometry-based lipidomics to map the mediator lipidome during the transition from inflammation to resolution and regeneration in skeletal muscle injury. We observed temporal regulation of glycerophospholipids and production of pro-inflammatory lipid mediators (for example, leukotrienes and prostaglandins) and specialized pro-resolving lipid mediators (for example, resolvins and lipoxins) that were modulated by ibuprofen. These time-dependent profiles were recapitulated in sorted neutrophils and Ly6C
Identifiants
pubmed: 30936495
doi: 10.1038/s41590-019-0356-7
pii: 10.1038/s41590-019-0356-7
pmc: PMC6537107
mid: NIHMS1522286
doi:
Substances chimiques
Inflammation Mediators
0
Lipids
0
resolvin D2
0
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
626-636Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL106173
Pays : United States
Organisme : NIH HHS
ID : R01DK115924
Pays : United States
Organisme : NIH HHS
ID : GM095467
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115924
Pays : United States
Organisme : NIGMS NIH HHS
ID : P01 GM095467
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL136044
Pays : United States
Commentaires et corrections
Type : ErratumIn
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