Regulation of Noise-Induced Loss of Serotonin Transporters with Resveratrol in a Rat Model Using 4-[
Animals
Brain
/ drug effects
Corpus Striatum
/ drug effects
Fluorine Radioisotopes
/ administration & dosage
Humans
Immunohistochemistry
Positron-Emission Tomography
Rats
Resveratrol
/ administration & dosage
Serotonin
/ chemistry
Serotonin Plasma Membrane Transport Proteins
/ drug effects
Selective Serotonin Reuptake Inhibitors
/ administration & dosage
Tissue Distribution
/ drug effects
4-[18F]-ADAM
noise-induced hearing loss
resveratrol
serotonin transporters
small-animal PET
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
05 Apr 2019
05 Apr 2019
Historique:
received:
19
02
2019
revised:
28
03
2019
accepted:
04
04
2019
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
28
7
2019
Statut:
epublish
Résumé
Serotonin (5-HT) plays a crucial role in modulating the afferent fiber discharge rate in the inferior colliculus, auditory cortex, and other nuclei of the ascending auditory system. Resveratrol, a natural polyphenol phytoalexin, can inhibit serotonin transporters (SERT) to increase synaptic 5-HT levels. In this study, we investigated the effects of resveratrol on noise-induced damage in the serotonergic system. Male Sprague-Dawley rats were anaesthetized and exposed to an 8-kHz tone at 116 dB for 3.5 h. Resveratrol (30 mg/kg, intraperitoneal injection [IP]) and citalopram (20 mg/kg, IP), a specific SERT inhibitor used as a positive control, were administered once a day for four consecutive days, with the first treatment occurring 2 days before noise exposure. Auditory brainstem response testing and positron emission tomography (PET) with
Identifiants
pubmed: 30959762
pii: molecules24071344
doi: 10.3390/molecules24071344
pmc: PMC6480549
pii:
doi:
Substances chimiques
Fluorine Radioisotopes
0
Serotonin Plasma Membrane Transport Proteins
0
Serotonin Uptake Inhibitors
0
Serotonin
333DO1RDJY
Resveratrol
Q369O8926L
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Science and Technology, Taiwan
ID : MOST 102-2314-B-016 -050 and 103-2314-B-016-002
Organisme : Tri-Service General Hospital, Taipei, Taiwan
ID : TSGH-C108-156
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