Profiling the Mutational Landscape in Known Driver Genes and Novel Genes in African American Non-Small Cell Lung Cancer Patients.
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 07 2019
15 07 2019
Historique:
received:
27
07
2018
revised:
07
12
2018
accepted:
05
04
2019
pubmed:
14
4
2019
medline:
23
9
2020
entrez:
14
4
2019
Statut:
ppublish
Résumé
Identifying novel driver genes and mutations in African American non-small cell lung cancer (NSCLC) cases can inform targeted therapy and improve outcomes for this traditionally underrepresented population. Tumor DNA, RNA, and germline DNA were collected from African American NSCLC patients who participated in research conducted at the Karmanos Cancer Institute (KCI) in Detroit, Michigan. Known mutations were ascertained through the Sequenom LungCarta panel of 214 mutations in 26 genes, Of the 193 tumors tested, 77 known driver mutations were identified in 66 patients (34.2%). Sixty-seven of the 127 patients without a known driver mutation were sequenced. In 54 of these patients, 50 nonsynonymous mutations were predicted to have damaging effects among the 26 panel genes, 47 of which are not found in The Cancer Genome Atlas NSCLC white or African American samples. Analyzing the whole-exome sequence data using MutSig2CV identified a total of 88 genes significantly mutated at FDR These findings suggest that broader mutation profiling including both known and novel driver genes in African Americans with NSCLC will identify additional mutations that may be useful in treatment decision-making.
Identifiants
pubmed: 30979741
pii: 1078-0432.CCR-18-2439
doi: 10.1158/1078-0432.CCR-18-2439
pmc: PMC6635071
mid: NIHMS1526990
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4300-4308Subventions
Organisme : NCI NIH HHS
ID : R01 CA141769
Pays : United States
Organisme : CCR NIH HHS
ID : HHSN261201300011C
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC065064
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201300011I
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA184778
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009531
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA022453
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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