Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants.
Adolescent
Adult
Aged
Aged, 80 and over
Azathioprine
/ administration & dosage
Biotransformation
Female
Gene Deletion
Glutathione Transferase
/ genetics
High-Throughput Nucleotide Sequencing
Humans
Immunosuppressive Agents
/ administration & dosage
Inflammatory Bowel Diseases
/ drug therapy
Male
Methyltransferases
/ genetics
Middle Aged
Pharmacogenomic Variants
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Treatment Outcome
Young Adult
azathioprine
glutathione-S transferase
inflammatory bowel disease
pharmacogenetics
pharmacokinetics
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
04 04 2019
04 04 2019
Historique:
received:
19
02
2019
revised:
01
04
2019
accepted:
01
04
2019
entrez:
17
4
2019
pubmed:
17
4
2019
medline:
17
4
2019
Statut:
epublish
Résumé
The contribution of candidate genetic variants involved in azathioprine biotransformation on azathioprine efficacy and pharmacokinetics in 111 young patients with inflammatory bowel disease was evaluated. Azathioprine doses, metabolites thioguanine-nucleotides (TGN) and methylmercaptopurine-nucleotides (MMPN) and clinical effects were assessed after at least 3 months of therapy. Clinical efficacy was defined as disease activity score below 10. Candidate genetic variants (
Identifiants
pubmed: 30987408
pii: genes10040277
doi: 10.3390/genes10040277
pmc: PMC6523194
pii:
doi:
Substances chimiques
Immunosuppressive Agents
0
Methyltransferases
EC 2.1.1.-
TPMT protein, human
EC 2.1.1.67
glutathione S-transferase T1
EC 2.5.1.-
GSTA1 protein, human
EC 2.5.1.18
Glutathione Transferase
EC 2.5.1.18
glutathione S-transferase M1
EC 2.5.1.18
Azathioprine
MRK240IY2L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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