Activation of P-TEFb by RBM7: To Live or Let Die.

DNA Damage Positive Transcriptional Elongation Factor B Promoter Regions, Genetic RNA Polymerase II

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
18 04 2019
Historique:
entrez: 20 4 2019
pubmed: 20 4 2019
medline: 12 10 2019
Statut: ppublish

Résumé

In this issue of Molecular Cell, Bugai et al. (2019) unveil that a key step of the pro-survival cellular response to a genotoxic attack is the activation of P-TEFb by RBM7. This crucial step triggers RNA polymerase II release from promoter-proximal pausing and expression of DNA damage response genes.

Identifiants

DOI: 10.1016/j.molcel.2019.03.039 PMID: 31002802
pubmed: 31002802
pii: S1097-2765(19)30268-0
doi: 10.1016/j.molcel.2019.03.039
pii:
doi:

Substances chimiques

Positive Transcriptional Elongation Factor B EC 2.7.11.-
RNA Polymerase II EC 2.7.7.-

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

223-224

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Nicolas Le May (N)

IGBMC (CNRS, INSERM, UdS), 1 rue Laurent Fries, 67400 Illkirch Graffenstaden, France.

Frédéric Coin (F)

IGBMC (CNRS, INSERM, UdS), 1 rue Laurent Fries, 67400 Illkirch Graffenstaden, France. Electronic address: fredr@igbmc.fr.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Activation of P-TEFb by RBM7: To Live or Let Die.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs d'élongation transcriptionnelle › Facteur B d'élongation transcriptionnelle positive › Activation of P-TEFb by RBM7: To Live or Let Die.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Activation of P-TEFb by RBM7: To Live or Let Die.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › RNA polymerase II › Activation of P-TEFb by RBM7: To Live or Let Die.