Sesquiterpenoids and 2-(2-phenylethyl)chromones respectively acting as α-glucosidase and tyrosinase inhibitors from agarwood of an Aquilaria plant.
Chromones
/ chemistry
Enzyme Inhibitors
/ chemistry
Glycoside Hydrolase Inhibitors
/ chemistry
Inhibitory Concentration 50
Kinetics
Molecular Docking Simulation
Molecular Structure
Monophenol Monooxygenase
/ antagonists & inhibitors
Sesquiterpenes
/ chemistry
Spectrum Analysis
/ methods
Thymelaeaceae
/ chemistry
Wood
/ chemistry
2-(2-phenylethyl)chromone
Agarwood
aquilaria plant
sesquiterpenoid
tyrosinase inhibition
α-glucosidase inhibition
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
24
4
2019
pubmed:
24
4
2019
medline:
2
5
2019
Statut:
ppublish
Résumé
The ethyl ether extract of agarwood from an Aquilaria plant afforded six new sesquiterpenoids, Agarozizanol A - F (1-6), together with four known sesquiterpenoids and six known 2-(2-phenylethyl)chromones. Their structures were elucidated via detailed spectroscopic analysis, X-ray diffraction, and comparisons with the published data. All the isolates were evaluated for the α-glucosidase and tyrosinase inhibitory activities in vitro. Compounds 5, 7, 8, and 10 showed significant inhibition of α-glucosidase with IC
Identifiants
pubmed: 31010356
doi: 10.1080/14756366.2019.1576657
pmc: PMC6495113
doi:
Substances chimiques
Chromones
0
Enzyme Inhibitors
0
Glycoside Hydrolase Inhibitors
0
Sesquiterpenes
0
Monophenol Monooxygenase
EC 1.14.18.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
853-862Références
Chem Pharm Bull (Tokyo). 2003 May;51(5):560-4
pubmed: 12736456
Crit Rev Food Sci Nutr. 1992;32(3):253-73
pubmed: 1418602
Curr Med Chem. 2005;12(4):461-9
pubmed: 15720254
J Comput Chem. 2007 Apr 30;28(6):1145-52
pubmed: 17274016
Insect Biochem Mol Biol. 2007 Dec;37(12):1327-37
pubmed: 17967351
Trends Biotechnol. 2009 Apr;27(4):199-209
pubmed: 19250692
Int J Mol Sci. 2009 May 26;10(6):2440-75
pubmed: 19582213
Pigment Cell Melanoma Res. 2009 Dec;22(6):750-60
pubmed: 19735457
Am J Ther. 2011 Mar-Apr;18(2):117-52
pubmed: 19834322
Phytochemistry. 2012 Apr;76:92-7
pubmed: 22243963
J Nat Prod. 2013 Feb 22;76(2):216-22
pubmed: 23394318
Planta Med. 2013 Sep;79(14):1329-34
pubmed: 23929247
J Asian Nat Prod Res. 2014;16(7):770-6
pubmed: 24646200
Fitoterapia. 2015 Jan;100:44-9
pubmed: 25447164
Fitoterapia. 2016 Apr;110:38-43
pubmed: 26784520
Eur J Med Chem. 2016 May 23;114:201-8
pubmed: 26974386
J Ethnopharmacol. 2016 Aug 2;189:331-60
pubmed: 27343768
Molecules. 2016 Oct 03;21(10):
pubmed: 27706109
Fitoterapia. 2017 Apr;118:49-55
pubmed: 28237880
J Enzyme Inhib Med Chem. 2017 Dec;32(1):1195-1202
pubmed: 28933230
J Nat Prod. 2018 Mar 23;81(3):543-553
pubmed: 29227647
J Enzyme Inhib Med Chem. 2018 Dec;33(1):1048-1054
pubmed: 29873272
Bioorg Chem. 2018 Dec;81:168-174
pubmed: 30130649
FEBS Lett. 1986 Jul 14;203(1):3-6
pubmed: 3720956
N Engl J Med. 1993 Jun 10;328(23):1676-85
pubmed: 8487827
Brain Res Mol Brain Res. 1997 Apr;45(1):159-62
pubmed: 9105685