Identification of a mesenchymal progenitor cell hierarchy in adipose tissue.

Adipocytes / cytology Adipogenesis Adipose Tissue / cytology Animals Dipeptidyl Peptidase 4 / metabolism Hematopoietic Cell Growth Factors / metabolism Humans Intercellular Adhesion Molecule-1 / metabolism Lectins, C-Type / metabolism Mesenchymal Stem Cells / cytology Mice Sequence Analysis, RNA Single-Cell Analysis Thromboplastin / metabolism Transforming Growth Factor beta / metabolism

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
26 04 2019
Historique:
received: 29 08 2018
accepted: 27 03 2019
entrez: 27 4 2019
pubmed: 27 4 2019
medline: 1 10 2019
Statut: ppublish

Résumé

Metabolic health depends on the capacity of adipose tissue progenitor cells to undergo de novo adipogenesis. The cellular hierarchy and mechanisms governing adipocyte progenitor differentiation are incompletely understood. Through single-cell RNA sequence analyses, we show that the lineage hierarchy of adipocyte progenitors consists of distinct mesenchymal cell types that are present in both mouse and human adipose tissues. Cells marked by dipeptidyl peptidase-4 (DPP4)/CD26 expression are highly proliferative, multipotent progenitors. During the development of subcutaneous adipose tissue in mice, these progenitor cells give rise to intercellular adhesion molecule-1 (ICAM1)/CD54-expressing (CD54+) committed preadipocytes and a related adipogenic cell population marked by

Identifiants

DOI: 10.1126/science.aav2501 PMID: 31023895 PMC: PMC6816238
pubmed: 31023895
pii: 364/6438/eaav2501
doi: 10.1126/science.aav2501
pmc: PMC6816238
mid: NIHMS1053512
pii:
doi:

Substances chimiques

CLEC11A protein, human 0
Hematopoietic Cell Growth Factors 0
Lectins, C-Type 0
Transforming Growth Factor beta 0
Intercellular Adhesion Molecule-1 126547-89-5
Thromboplastin 9035-58-9
Dipeptidyl Peptidase 4 EC 3.4.14.5

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDDK NIH HHS
ID : R56 DK103008
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120982
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK122099
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008216
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103008
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107589
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007313
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007314
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK019525
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

David Merrick (D)

Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
ORCID: 0000-0001-6464-2705

Alexander Sakers (A)

Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
ORCID: 0000-0003-2010-7211

Zhazira Irgebay (Z)

Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
ORCID: 0000-0003-1373-3484

Chihiro Okada (C)

Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Catherine Calvert (C)

Division of Plastic Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Michael P Morley (MP)

Penn Center for Pulmonary Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
ORCID: 0000-0002-0958-7376

Ivona Percec (I)

Division of Plastic Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Patrick Seale (P)

Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. sealep@pennmedicine.upenn.edu.
Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
ORCID: 0000-0001-7119-1615

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Adipogenèse › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Eucaryotes › Animaux › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Dipeptidyl peptidase 4 › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de croissance hématopoïétique › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Molécule-1 d'adhérence intercellulaire › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Lectines de type C › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Thromboplastine › Identification of a mesenchymal progenitor...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Identification of a mesenchymal progenitor...