Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation.

Aspergillus nidulans / chemistry Cyclic AMP-Dependent Protein Kinases / metabolism Fungal Proteins / genetics Gene Deletion Gene Expression Profiling Gene Expression Regulation, Bacterial Phosphoproteins / analysis Protein Processing, Post-Translational Proteome / analysis Repressor Proteins / genetics
CreA phosphoproteomic phosphosite signal transduction transcriptomic

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
30 04 2019
Historique:
entrez: 2 5 2019
pubmed: 2 5 2019
medline: 25 6 2019
Statut: epublish

Résumé

In filamentous fungi, an important kinase responsible for adaptation to changes in available nutrients is cyclic AMP (cAMP)-dependent protein kinase (protein kinase A [PKA]). This kinase has been well characterized at a molecular level, but its systemic action and direct/indirect targets are generally not well understood in filamentous fungi. In this work, we used a

Identifiants

DOI: 10.1128/mBio.02825-18 PMID: 31040248 PMC: PMC6495382
pubmed: 31040248
pii: mBio.02825-18
doi: 10.1128/mBio.02825-18
pmc: PMC6495382
pii:
doi:

Substances chimiques

Fungal Proteins 0
Phosphoproteins 0
Proteome 0
Repressor Proteins 0
CreA protein, Aspergillus nidulans 144516-87-0
Cyclic AMP-Dependent Protein Kinases EC 2.7.11.11

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 Ribeiro et al.

Références

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Auteurs

Liliane F C Ribeiro (LFC)

Department of Chemical, Biochemical and Environmental Engineering, University of Maryland, Baltimore County (UMBC), Baltimore, Maryland, USA.

Cynthia Chelius (C)

Department of Chemical, Biochemical and Environmental Engineering, University of Maryland, Baltimore County (UMBC), Baltimore, Maryland, USA.

Karthik R Boppidi (KR)

Department of Chemical, Biochemical and Environmental Engineering, University of Maryland, Baltimore County (UMBC), Baltimore, Maryland, USA.

Nisha S Naik (NS)

Department of Chemical, Biochemical and Environmental Engineering, University of Maryland, Baltimore County (UMBC), Baltimore, Maryland, USA.

Simin Hossain (S)

Department of Chemical, Biochemical and Environmental Engineering, University of Maryland, Baltimore County (UMBC), Baltimore, Maryland, USA.

Jessica J J Ramsey (JJJ)

Department of Chemical, Biochemical and Environmental Engineering, University of Maryland, Baltimore County (UMBC), Baltimore, Maryland, USA.

Jyothi Kumar (J)

Center for Plant Science Innovation, University of Nebraska, Lincoln, Nebraska, USA.

Lucas F Ribeiro (LF)

Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Marc Ostermeier (M)

Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Bao Tran (B)

Mass Spectrometry Center, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.

Young Ah Goo (Y)

Mass Spectrometry Center, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.

Leandro J de Assis (LJ)

Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.

Mevlut Ulas (M)

Department of Biology, Maynooth University, Maynooth, County Kildare, Ireland.

Ozgur Bayram (O)

Department of Biology, Maynooth University, Maynooth, County Kildare, Ireland.

Gustavo H Goldman (GH)

Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, CEP 14040-903, São Paulo, Brazil.
Institute for Advanced Study, Technical University of Munich, Garching, Germany.
ORCID: 0000-0002-2986-350X

Stephen Lincoln (S)

Chemical & Biomolecular Engineering Department, University of Connecticut, Storrs, Connecticut, USA.

Ranjan Srivastava (R)

Chemical & Biomolecular Engineering Department, University of Connecticut, Storrs, Connecticut, USA.

Steven D Harris (SD)

Center for Plant Science Innovation, University of Nebraska, Lincoln, Nebraska, USA.

Mark R Marten (MR)

Department of Chemical, Biochemical and Environmental Engineering, University of Maryland, Baltimore County (UMBC), Baltimore, Maryland, USA marten@umbc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Aspergillus › Aspergillus nidulans › Comprehensive Analysis of Aspergillus nidulans...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Cyclic Nucleotide-Regulated Protein Kinases › Cyclic AMP-Dependent Protein Kinases › Comprehensive Analysis of Aspergillus nidulans...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Comprehensive Analysis of Aspergillus nidulans...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › Comprehensive Analysis of Aspergillus nidulans...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Comprehensive Analysis of Aspergillus nidulans...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes bactériens › Comprehensive Analysis of Aspergillus nidulans...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Comprehensive Analysis of Aspergillus nidulans...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Comprehensive Analysis of Aspergillus nidulans...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › Comprehensive Analysis of Aspergillus nidulans...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Comprehensive Analysis of Aspergillus nidulans...