The DEAD-box RNA helicase Ded1 has a role in the translational response to TORC1 inhibition.
5' Untranslated Regions
Cytoplasm
/ metabolism
DEAD-box RNA Helicases
/ genetics
Eukaryotic Initiation Factor-4F
/ metabolism
Nucleic Acid Conformation
Peptide Chain Elongation, Translational
Protein Biosynthesis
RNA, Messenger
/ metabolism
Saccharomyces cerevisiae
/ genetics
Saccharomyces cerevisiae Proteins
/ antagonists & inhibitors
Transcription Factors
/ antagonists & inhibitors
Journal
Molecular biology of the cell
ISSN: 1939-4586
Titre abrégé: Mol Biol Cell
Pays: United States
ID NLM: 9201390
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
pubmed:
30
5
2019
medline:
12
6
2020
entrez:
30
5
2019
Statut:
ppublish
Résumé
Ded1 is a DEAD-box RNA helicase with essential roles in translation initiation. It binds to the eukaryotic initiation factor 4F (eIF4F) complex and promotes 48S preinitiation complex assembly and start-site scanning of 5' untranslated regions of mRNAs. Most prior studies of Ded1 cellular function were conducted in steady-state conditions during nutrient-rich growth. In this work, however, we examine its role in the translational response during target of rapamycin (TOR)C1 inhibition and identify a novel function of Ded1 as a translation repressor. We show that C-terminal mutants of
Identifiants
pubmed: 31141444
doi: 10.1091/mbc.E18-11-0702
pmc: PMC6743465
doi:
Substances chimiques
5' Untranslated Regions
0
Eukaryotic Initiation Factor-4F
0
RNA, Messenger
0
Saccharomyces cerevisiae Proteins
0
TORC1 protein complex, S cerevisiae
0
Transcription Factors
0
DED1 protein, S cerevisiae
EC 3.6.1.-
DEAD-box RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2171-2184Références
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