Application of Dynamic Regulation to Increase L-Phenylalanine Production in
Amino Acid Transport Systems, Neutral
/ genetics
Biosynthetic Pathways
/ genetics
Escherichia coli
/ genetics
Escherichia coli Proteins
/ genetics
Fermentation
Gene Expression Regulation, Bacterial
Glucose
/ metabolism
Industrial Microbiology
/ methods
Metabolic Engineering
/ methods
Metabolic Flux Analysis
Mutation
Phenylalanine
/ biosynthesis
Phosphotransferases (Alcohol Group Acceptor)
/ genetics
Promoter Regions, Genetic
AroK
E. coli
L-Phenylalanine
dynamic regulation
fermentation
Journal
Journal of microbiology and biotechnology
ISSN: 1738-8872
Titre abrégé: J Microbiol Biotechnol
Pays: Korea (South)
ID NLM: 9431852
Informations de publication
Date de publication:
28 Jun 2019
28 Jun 2019
Historique:
pubmed:
4
6
2019
medline:
14
8
2019
entrez:
4
6
2019
Statut:
ppublish
Résumé
Current strategies of strain improvement processes are mainly focused on enhancing the synthetic pathways of the products. However, excessive metabolic flux often creates metabolic imbalances, which lead to growth retardation and ultimately limit the yield of the product. To solve this problem, we applied a dynamic regulation strategy to produce L-phenylalanine (LPhe) in
Identifiants
pubmed: 31154747
pii: 10.4014/jmb.1901.01058
doi: 10.4014/jmb.1901.01058
doi:
Substances chimiques
Amino Acid Transport Systems, Neutral
0
Escherichia coli Proteins
0
tyrP protein, E coli
0
Phenylalanine
47E5O17Y3R
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
shikimate kinase
EC 2.7.1.71
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng