On the occurrence of cytochrome P450 in viruses.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
18 06 2019
Historique:
pubmed: 7 6 2019
medline: 9 4 2020
entrez: 7 6 2019
Statut: ppublish

Résumé

Genes encoding cytochrome P450 (CYP; P450) enzymes occur widely in the Archaea, Bacteria, and Eukarya, where they play important roles in metabolism of endogenous regulatory molecules and exogenous chemicals. We now report that genes for multiple and unique P450s occur commonly in giant viruses in the

Identifiants

pubmed: 31167942
pii: 1901080116
doi: 10.1073/pnas.1901080116
pmc: PMC6589655
doi:

Substances chimiques

Cytochrome P-450 Enzyme System 9035-51-2

Banques de données

PDB
['6N6Q']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

12343-12352

Subventions

Organisme : NIEHS NIH HHS
ID : P42 ES007381
Pays : United States
Organisme : NIEHS NIH HHS
ID : P01 ES021923
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG003345
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131920
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM057353
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

David C Lamb (DC)

Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543.
Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, SA2 8PP Wales, United Kingdom.

Alec H Follmer (AH)

Department of Chemistry, University of California, Irvine, CA 92697-3900.

Jared V Goldstone (JV)

Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543.

David R Nelson (DR)

Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163.

Andrew G Warrilow (AG)

Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, SA2 8PP Wales, United Kingdom.

Claire L Price (CL)

Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, SA2 8PP Wales, United Kingdom.

Marie Y True (MY)

Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697-3900.

Steven L Kelly (SL)

Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, SA2 8PP Wales, United Kingdom.

Thomas L Poulos (TL)

Department of Chemistry, University of California, Irvine, CA 92697-3900.
Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697-3900.
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900.

John J Stegeman (JJ)

Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543; jstegeman@whoi.edu.

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Classifications MeSH