Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.

Aged Aged, 80 and over Angiotensin II / administration & dosage Angiotensin-Converting Enzyme 2 Animals Aorta, Abdominal / cytology Aortic Aneurysm, Abdominal / drug therapy Apelin / genetics Apoptosis / drug effects Cardiovascular Agents / chemistry Diet, High-Fat / adverse effects Disease Models, Animal Female Gene Knockdown Techniques Humans Male Mice, Transgenic Middle Aged Myocytes, Smooth Muscle Neprilysin / genetics Oxidative Stress / drug effects Peptidyl-Dipeptidase A / metabolism Phenylephrine / administration & dosage Primary Cell Culture Proteolysis / drug effects RNA, Small Interfering / metabolism Receptors, LDL / genetics Vascular Remodeling / drug effects
ACE2 aneurysm angiotensin II apelin neutral endopeptidase

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
25 06 2019
Historique:
pubmed: 14 6 2019
medline: 9 4 2020
entrez: 14 6 2019
Statut: ppublish

Résumé

Abdominal aortic aneurysm (AAA) remains the second most frequent vascular disease with high mortality but has no approved medical therapy. We investigated the direct role of apelin (APLN) in AAA and identified a unique approach to enhance APLN action as a therapeutic intervention for this disease. Loss of APLN potentiated angiotensin II (Ang II)-induced AAA formation, aortic rupture, and reduced survival. Formation of AAA was driven by increased smooth muscle cell (SMC) apoptosis and oxidative stress in

Identifiants

DOI: 10.1073/pnas.1900152116 PMID: 31189595 PMC: PMC6600956
pubmed: 31189595
pii: 1900152116
doi: 10.1073/pnas.1900152116
pmc: PMC6600956
doi:

Substances chimiques

APLN protein, human 0
Apelin 0
Apln protein, mouse 0
Cardiovascular Agents 0
LDLR protein, human 0
RNA, Small Interfering 0
Receptors, LDL 0
Angiotensin II 11128-99-7
Phenylephrine 1WS297W6MV
Peptidyl-Dipeptidase A EC 3.4.15.1
ACE2 protein, human EC 3.4.17.23
Ace2 protein, mouse EC 3.4.17.23
Angiotensin-Converting Enzyme 2 EC 3.4.17.23
Neprilysin EC 3.4.24.11

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

13006-13015

Subventions

Organisme : CIHR
ID : PJT153306
Pays : Canada
Organisme : CIHR
ID : 136921
Pays : Canada

Informations de copyright

Copyright © 2019 the Author(s). Published by PNAS.

Références

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Auteurs

Wang Wang (W)

Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB T6G 2G3, Canada.
Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB T6G 2J2, Canada.
Department of Physiology, University of Alberta, Edmonton, AB T6G 2R7, Canada.

Mengcheng Shen (M)

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB T6G 2J2, Canada.
Department of Physiology, University of Alberta, Edmonton, AB T6G 2R7, Canada.

Conrad Fischer (C)

Department of Chemistry, University of Alberta, Edmonton, AB T6G 2N4, Canada.

Ratnadeep Basu (R)

Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB T6G 2G3, Canada.
Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB T6G 2J2, Canada.

Saugata Hazra (S)

Department of Biotechnology, Indian Institute of Technology, 247667 Roorkee, Uttarakhand, India.
Centre for Nanotechnology, Indian Institute of Technology, 247667 Roorkee, Uttarakhand, India.

Pierre Couvineau (P)

Department of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Montreal, Montreal, QC H3C 3J7, Canada.

Manish Paul (M)

Department of Biotechnology, North Orissa University, 757003 Baripada, Odisha, India.

Faqi Wang (F)

Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB T6G 2G3, Canada.
Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB T6G 2J2, Canada.

Sandra Toth (S)

Division of Vascular Surgery, University of Rochester, Rochester, NY 14642.

Doran S Mix (DS)

Division of Vascular Surgery, University of Rochester, Rochester, NY 14642.

Marko Poglitsch (M)

Attoquant Diagnostics, 1030 Vienna, Austria.

Norma P Gerard (NP)

Boston Children's Hospital, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115.

Michel Bouvier (M)

Department of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Montreal, Montreal, QC H3C 3J7, Canada.
ORCID: 0000-0003-1128-0100

John C Vederas (JC)

Department of Chemistry, University of Alberta, Edmonton, AB T6G 2N4, Canada.

Josef M Penninger (JM)

Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC V6H 3N1, Canada.

Zamaneh Kassiri (Z)

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB T6G 2J2, Canada.
Department of Physiology, University of Alberta, Edmonton, AB T6G 2R7, Canada.

Gavin Y Oudit (GY)

Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB T6G 2G3, Canada; gavin.oudit@ualberta.ca.
Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB T6G 2J2, Canada.
Department of Physiology, University of Alberta, Edmonton, AB T6G 2R7, Canada.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Apelin protects against abdominal aortic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Apelin protects against abdominal aortic...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Angiotensines › Angiotensine-II › Apelin protects against abdominal aortic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Carboxypeptidases › Angiotensin-converting enzyme 2 › Apelin protects against abdominal aortic...
questionsmedicales.fr › Eucaryotes › Animaux › Apelin protects against abdominal aortic...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Aorte › Aorte abdominale › Apelin protects against abdominal aortic...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Maladies de l'aorte › Anévrysme de l'aorte › Anévrysme de l'aorte abdominale › Apelin protects against abdominal aortic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Apeline › Apelin protects against abdominal aortic...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Apelin protects against abdominal aortic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Apelin protects against abdominal aortic...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Apelin protects against abdominal aortic...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Apelin protects against abdominal aortic...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-down de gènes › Apelin protects against abdominal aortic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Apelin protects against abdominal aortic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Apelin protects against abdominal aortic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Apelin protects against abdominal aortic...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › Apelin protects against abdominal aortic...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Néprilysine › Apelin protects against abdominal aortic...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Apelin protects against abdominal aortic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Dipeptidyl-Peptidases and Tripeptidyl-Peptidases › Peptidyl-Dipeptidase A › Apelin protects against abdominal aortic...
questionsmedicales.fr › Composés chimiques organiques › Amines › Aminoalcools › Éthanolamines › Phényléphrine › Apelin protects against abdominal aortic...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Culture de cellules primaires › Apelin protects against abdominal aortic...
questionsmedicales.fr › Métabolisme › Protéolyse › Apelin protects against abdominal aortic...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Apelin protects against abdominal aortic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Apelin protects against abdominal aortic...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Remodelage vasculaire › Apelin protects against abdominal aortic...