Bioactive secondary metabolites from new endophytic fungus Curvularia. sp isolated from Rauwolfia macrophylla.
Antioxidants
/ pharmacology
Ascomycota
/ classification
Bacteria
/ drug effects
Cholinesterase Inhibitors
/ pharmacology
Endophytes
/ metabolism
Fermentation
Free Radical Scavengers
/ pharmacology
Microbial Sensitivity Tests
Phylogeny
Phytochemicals
/ chemistry
Rauwolfia
/ microbiology
Secondary Metabolism
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
12
2018
accepted:
15
05
2019
entrez:
28
6
2019
pubmed:
28
6
2019
medline:
12
2
2020
Statut:
epublish
Résumé
Over the last decades, endophytic fungi represent a new source of pharmacologically active secondary metabolites based on the underlying assumption that they live symbiotically within their plant host. In the present study, a new endophytic fungus was isolated from Rauwolfia macrophylla, a medicinal plant from Cameroon. The fungus showed a highest homology to Curvularia sp. based on complete nucleotide sequence data generated from the internal transcribed spacer (ITS) of ribosomal DNA region. Large scale fermentation, working-up and separation of the strain extract using different chromatographic techniques afforded three bioactive compounds: 2'-deoxyribolactone (1), hexylitaconic acid (2) and ergosterol (3). The chemical structures of compounds 1-3 were confirmed by 1 and 2D NMR spectroscopy and mass spectrometry, and comparison with corresponding literature data. Biologically, the antimicrobial, antioxidant activities and the acetylcholinesterase inhibitory of the isolated compounds were studied.
Identifiants
pubmed: 31247016
doi: 10.1371/journal.pone.0217627
pii: PONE-D-18-35553
pmc: PMC6597039
doi:
Substances chimiques
Antioxidants
0
Cholinesterase Inhibitors
0
Free Radical Scavengers
0
Phytochemicals
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0217627Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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