MIG1 as a positive regulator for the histidine biosynthesis pathway and as a global regulator in thermotolerant yeast Kluyveromyces marxianus.

Biosynthetic Pathways Gene Expression Regulation, Fungal Histidine / biosynthesis Kluyveromyces / growth & development Repressor Proteins / genetics Saccharomyces cerevisiae Proteins / genetics Thermotolerance

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
09 07 2019
Historique:
received: 11 03 2019
accepted: 27 06 2019
entrez: 11 7 2019
pubmed: 11 7 2019
medline: 4 11 2020
Statut: epublish

Résumé

Kmmig1 as a disrupted mutant of MIG1 encoding a regulator for glucose repression in Kluyveromyces marxianus exhibits a histidine-auxotrophic phenotype. Genome-wide expression analysis revealed that only HIS4 in seven HIS genes for histidine biosynthesis was down-regulated in Kmmig1. Consistently, introduction of HIS4 into Kmmig1 suppressed the requirement of histidine. Considering the fact that His4 catalyzes four of ten steps in histidine biosynthesis, K. marxianus has evolved a novel and effective regulation mechanism via Mig1 for the control of histidine biosynthesis. Moreover, RNA-Seq analysis revealed that there were more than 1,000 differentially expressed genes in Kmmig1, suggesting that Mig1 is directly or indirectly involved in the regulation of their expression as a global regulator.

Identifiants

DOI: 10.1038/s41598-019-46411-5 PMID: 31289320 PMC: PMC6617469
pubmed: 31289320
doi: 10.1038/s41598-019-46411-5
pii: 10.1038/s41598-019-46411-5
pmc: PMC6617469
doi:

Substances chimiques

MIG1 protein, S cerevisiae 0
Repressor Proteins 0
Saccharomyces cerevisiae Proteins 0
Histidine 4QD397987E

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9926

Commentaires et corrections

Type : ErratumIn

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Auteurs

Mochamad Nurcholis (M)

Graduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan.
Department of Food Science and Technology, Faculty of Agricultural Technology, Brawijaya University, Malang, 65145, Indonesia.

Masayuki Murata (M)

Graduate School of Science and Technology for Innovation, Yamaguchi University, Yamaguchi, 753-8515, Japan.

Savitree Limtong (S)

Department of Microbiology, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand.

Tomoyuki Kosaka (T)

Graduate School of Science and Technology for Innovation, Yamaguchi University, Yamaguchi, 753-8515, Japan.
Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi, 753-8515, Japan.
Research Center for Thermotolerant Microbial Resources, Yamaguchi University, Yamaguchi, 753-8315, Japan.

Mamoru Yamada (M)

Graduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan. m-yamada@yamaguchi-u.ac.jp.
Graduate School of Science and Technology for Innovation, Yamaguchi University, Yamaguchi, 753-8515, Japan. m-yamada@yamaguchi-u.ac.jp.
Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi, 753-8515, Japan. m-yamada@yamaguchi-u.ac.jp.
Research Center for Thermotolerant Microbial Resources, Yamaguchi University, Yamaguchi, 753-8315, Japan. m-yamada@yamaguchi-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Voies de biosynthèse › MIG1 as a positive regulator for the histidine...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes fongiques › MIG1 as a positive regulator for the histidine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Histidine › MIG1 as a positive regulator for the histidine...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Kluyveromyces › MIG1 as a positive regulator for the histidine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › MIG1 as a positive regulator for the histidine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › MIG1 as a positive regulator for the histidine...
questionsmedicales.fr › Phénomènes biologiques › Adaptation biologique › Adaptation physiologique › Acclimatation › Thermotolérance › MIG1 as a positive regulator for the histidine...