The Spectrum of α-Thalassemia Mutations in the Lak Population of Iran.

Genotype Heterozygote Humans Iran / epidemiology Mutation Sequence Analysis, DNA / methods alpha-Globins / genetics alpha-Thalassemia / ethnology
Iran gene mutation α-Thalassemia (α-thal)

Journal

Hemoglobin
ISSN: 1532-432X
Titre abrégé: Hemoglobin
Pays: England
ID NLM: 7705865

Informations de publication

Date de publication:
Mar 2019
Historique:
entrez: 16 7 2019
pubmed: 16 7 2019
medline: 14 1 2020
Statut: ppublish

Résumé

α-Thalassemia (α-thal) is one of the most common genetic disorders worldwide. The aim of this study was to investigate for the first time the α-thal mutation spectrum in the Lak population living in Lorestan Province, Iran. One hundred and seventy-six α-thal carriers participated in the study. Multiplex gap-polymerase chain reaction (gap-PCR), amplification refractory mutation system (ARMS)-PCR and direct sequencing were used for the detection of different mutations on the α-globin (

Identifiants

DOI: 10.1080/03630269.2019.1614049 PMID: 31304855
pubmed: 31304855
doi: 10.1080/03630269.2019.1614049
doi:

Substances chimiques

alpha-Globins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

107-111

Auteurs

Keivan Moradi (K)

a Medical Biology Research Center , Kermanshah University of Medical Sciences , Kermanshah , Iran.

Mozaffar Aznab (M)

b Department of Hematology Oncology, School of Medicine , Kermanshah University of Medical Sciences , Kermanshah , Iran.

Susan Tahmasebi (S)

c Medical Genetics Laboratory , Kermanshah University of Medical Sciences , Kermanshah , Iran.

Zahra Dastafkan (Z)

c Medical Genetics Laboratory , Kermanshah University of Medical Sciences , Kermanshah , Iran.

Leila Omidniakan (L)

c Medical Genetics Laboratory , Kermanshah University of Medical Sciences , Kermanshah , Iran.

Mahsa Ahmadi (M)

c Medical Genetics Laboratory , Kermanshah University of Medical Sciences , Kermanshah , Iran.

Reza Alibakhshi (R)

d Department of Biochemistry, School of Medicine , Kermanshah University of Medical Sciences , Kermanshah , Iran.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Génotype › The Spectrum of α-Thalassemia Mutations in the...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Hétérozygote › The Spectrum of α-Thalassemia Mutations in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Spectrum of α-Thalassemia Mutations in the...
questionsmedicales.fr › Régions géographiques › Asie › Asie de l'Ouest › Moyen Orient › Iran › The Spectrum of α-Thalassemia Mutations in the...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › The Spectrum of α-Thalassemia Mutations in the...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › The Spectrum of α-Thalassemia Mutations in the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Globines › Hémoglobines › Sous-unités de l'hémoglobine › Globines alpha › The Spectrum of α-Thalassemia Mutations in the...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Hémoglobinopathies › Thalassémie › alpha-Thalassémie › The Spectrum of α-Thalassemia Mutations in the...