HLA-A, -B, -C, -DRB1, and -DQB1 allele and haplotype frequencies: An analysis of umbilical cord blood units at the Barcelona Cord Blood Bank.
3' Untranslated Regions
Alleles
Blood Banks
Female
Fetal Blood
/ immunology
Gene Frequency
Genotype
HLA-A Antigens
/ genetics
HLA-A2 Antigen
/ genetics
HLA-B Antigens
/ genetics
HLA-B44 Antigen
/ genetics
HLA-C Antigens
/ genetics
HLA-DQ beta-Chains
/ genetics
HLA-DRB1 Chains
/ genetics
Haplotypes
Homozygote
Humans
Linkage Disequilibrium
Male
Mothers
Polymorphism, Single Nucleotide
Pregnancy
HLA
NGS
alleles
cord blood
frequencies
haplotypes
Journal
HLA
ISSN: 2059-2310
Titre abrégé: HLA
Pays: England
ID NLM: 101675570
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
04
02
2019
revised:
18
07
2019
accepted:
25
07
2019
pubmed:
30
7
2019
medline:
9
7
2020
entrez:
30
7
2019
Statut:
ppublish
Résumé
Allele-level HLA compatibility in cord blood transplantation has been associated with better transplant outcomes and is recommended as a selection criterion. It is also a crucial aspect for other therapeutic applications involving cord blood-derived cells. Determination of high-resolution HLA frequencies is an important step towards improving the quality of cord blood banks. We analyzed HLA-A, -B, -C, -DRB1, and -DQB1 allele frequencies in 5458 high-quality cord blood units from the Barcelona Cord Blood Bank and identified 275 class I and 121 class II HLA alleles. A*02:01, B*44:03, C*07:01, DRB1*07:01 and DQB1*03:01 were the most frequent alleles at each locus. We detected 26 novel alleles and were able to determine the presence or absence of some null alleles, including C*04:09N, in a large number of units. We also analyzed maternal HLA typing information for 1877 units to determine real haplotype frequencies and linkage disequilibrium. A*29:02-B*44:03-C*16:01-DRB1*07:01-DQB1*02:02 was the most frequent HLA haplotype and the DRB1-DQB1 gene pair contained the two-locus haplotypes with the strongest linkage disequilibrium values. Four of the 11 unique haplotypes identified in the HLA-homozygous cord blood units were the top-ranking haplotypes identified and were present in 18% of the cohort. This is the first study to report on HLA allele and haplotype frequencies for umbilical cord blood units from the Barcelona Cord Blood Bank and the largest study to date involving two fields of HLA resolution typing of Spanish registry data.
Substances chimiques
3' Untranslated Regions
0
HLA-A Antigens
0
HLA-A*02:01 antigen
0
HLA-A2 Antigen
0
HLA-A29 antigen
0
HLA-B Antigens
0
HLA-B*44:03 antigen
0
HLA-B44 Antigen
0
HLA-C Antigens
0
HLA-C*04:09N antigen
0
HLA-C*16 antigen
0
HLA-DQ beta-Chains
0
HLA-DQB1 antigen
0
HLA-DRB1 Chains
0
HLA-DRB1*07 antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
347-359Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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