Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5'-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization.

Carboxylic Acids / chemistry Catalytic Domain Decarboxylation Kinetics Models, Molecular Orotidine-5'-Phosphate Decarboxylase / chemistry Protein Conformation Protons Saccharomyces cerevisiae / chemistry Substrate Specificity Thermodynamics Uridine Monophosphate / analogs & derivatives

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
28 08 2019
Historique:
pubmed: 1 8 2019
medline: 2 10 2020
entrez: 1 8 2019
Statut: ppublish

Résumé

Kinetic parameters

Identifiants

DOI: 10.1021/jacs.9b04823 PMID: 31365243 PMC: PMC6735427
pubmed: 31365243
doi: 10.1021/jacs.9b04823
pmc: PMC6735427
doi:

Substances chimiques

Carboxylic Acids 0
Protons 0
orotidylic acid 2149-82-8
Uridine Monophosphate E2OU15WN0N
Orotidine-5'-Phosphate Decarboxylase EC 4.1.1.23

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

13468-13478

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM039754
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM116921
Pays : United States

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Auteurs

Bogdana Goryanova (B)

Department of Chemistry , University at Buffalo, SUNY , Buffalo , New York 14260-3000 , United States.

Tina L Amyes (TL)

Department of Chemistry , University at Buffalo, SUNY , Buffalo , New York 14260-3000 , United States.

John P Richard (JP)

Department of Chemistry , University at Buffalo, SUNY , Buffalo , New York 14260-3000 , United States.
ORCID: 0000-0002-0440-2387

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Role of the Carboxylate in Enzyme-Catalyzed...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Role of the Carboxylate in Enzyme-Catalyzed...
questionsmedicales.fr › Métabolisme › Décarboxylation › Role of the Carboxylate in Enzyme-Catalyzed...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Role of the Carboxylate in Enzyme-Catalyzed...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Role of the Carboxylate in Enzyme-Catalyzed...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-carbon lyases › Carboxy-lyases › Orotine 5'-phosphate decarboxylase › Role of the Carboxylate in Enzyme-Catalyzed...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Role of the Carboxylate in Enzyme-Catalyzed...
questionsmedicales.fr › Phénomènes physiques › Particules élémentaires › Nucléons › Protons › Role of the Carboxylate in Enzyme-Catalyzed...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Role of the Carboxylate in Enzyme-Catalyzed...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Role of the Carboxylate in Enzyme-Catalyzed...
questionsmedicales.fr › Phénomènes physiques › Thermodynamique › Role of the Carboxylate in Enzyme-Catalyzed...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides uridyliques › Uridine monophosphate › Role of the Carboxylate in Enzyme-Catalyzed...