Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury.

6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology Animals Arginine / analogs & derivatives Calcium Channel Blockers / pharmacology Capsaicin / pharmacology Cyclic AMP-Dependent Protein Kinases / metabolism Excitatory Amino Acid Antagonists / pharmacology Hyperalgesia / metabolism Indoles / pharmacology Interneurons / drug effects Lidocaine / pharmacology Male Microscopy, Confocal Neuropeptide Y / drug effects Nociception / drug effects Peripheral Nerve Injuries / metabolism Posterior Horn Cells / drug effects Potassium Chloride / pharmacology Protein Transport / drug effects Protein Tyrosine Phosphatases / antagonists & inhibitors Rats Receptors, N-Methyl-D-Aspartate / metabolism Receptors, Neuropeptide Y / drug effects Sensory System Agents / pharmacology Spinal Cord / drug effects Spinal Nerve Roots / drug effects TRPV Cation Channels / metabolism Voltage-Gated Sodium Channel Blockers / pharmacology omega-Conotoxins / pharmacology
1548943) 16132352) 180081) 22880) 3132) 439518) 44093) 5311022) 56841670) 6314) 6604934) 71077) 94701) Amastatin (PubChem CID BIBO3304 (PubChem CID BVT948 (PubChem CID C-fiber MK-801 (PubChem CID NMDA (PubChem CID Neuropathic pain Neurotransmitter release Nociception PubChem CID capsaicin (PubChem CID captopril (PubChem CID d-serine (PubChem CID diprotin A (Ile-Pro-Ile lidocaine (PubChem CID neuropeptide Y (PubChem CID thiorphan (PubChem CID ω-conotoxin MVIIC (PubChem CID

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
01 11 2019
Historique:
received: 20 06 2019
accepted: 31 07 2019
pubmed: 5 8 2019
medline: 21 7 2020
entrez: 5 8 2019
Statut: ppublish

Résumé

Neuropeptide Y (NPY) modulates nociception in the spinal cord, but little is known about its mechanisms of release. We measured NPY release in situ using the internalization of its Y1 receptor in dorsal horn neurons. Y1 receptor immunoreactivity was normally localized to the cell surface, but addition of NPY to spinal cord slices increased the number of neurons with Y1 internalization in a biphasic fashion (EC

Identifiants

DOI: 10.1016/j.neuropharm.2019.107732 PMID: 31377198 PMC: PMC6904115
pubmed: 31377198
pii: S0028-3908(19)30291-6
doi: 10.1016/j.neuropharm.2019.107732
pmc: PMC6904115
mid: NIHMS1538514
pii:
doi:

Substances chimiques

4-hydroxy-3,3-dimethyl-2H-benzo(g)indole-2,5(3H)-dione 0
Calcium Channel Blockers 0
Excitatory Amino Acid Antagonists 0
Indoles 0
Neuropeptide Y 0
Receptors, N-Methyl-D-Aspartate 0
Receptors, Neuropeptide Y 0
Sensory System Agents 0
TRPV Cation Channels 0
Trpv1 protein, rat 0
Voltage-Gated Sodium Channel Blockers 0
neuropeptide Y-Y1 receptor 0
omega-Conotoxins 0
omega-conotoxin-MVIIC 147794-23-8
Potassium Chloride 660YQ98I10
6-Cyano-7-nitroquinoxaline-2,3-dione 6OTE87SCCW
Arginine 94ZLA3W45F
Lidocaine 98PI200987
Cyclic AMP-Dependent Protein Kinases EC 2.7.11.11
Protein Tyrosine Phosphatases EC 3.1.3.48
BIBO 3304 O35HK034KO
Capsaicin S07O44R1ZM

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

107732

Subventions

Organisme : NIDA NIH HHS
ID : R01 DA037621
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS062306
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS045954
Pays : United States
Organisme : RRD VA
ID : I01 RX001646
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK041301
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA033059
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

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Auteurs

Juan Carlos Marvizon (JC)

Vatche and Tamar Manoukian Division of Digestive Diseases, 900 Veterans Ave., Warren Hall Building, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, 90095, USA; Veteran Affairs Greater Los Angeles Healthcare System, 11310 Wilshire Blvd., Building 115, Los Angeles, CA, 90073, USA. Electronic address: enkephalin@protonmail.com.

Wenling Chen (W)

Vatche and Tamar Manoukian Division of Digestive Diseases, 900 Veterans Ave., Warren Hall Building, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, 90095, USA; Veteran Affairs Greater Los Angeles Healthcare System, 11310 Wilshire Blvd., Building 115, Los Angeles, CA, 90073, USA. Electronic address: WenLingChen@mednet.ucla.edu.

Weisi Fu (W)

Department of Physiology, University of Kentucky Medical Center, Lexington, KY, USA. Electronic address: pencil2bfd@gmail.com.

Bradley K Taylor (BK)

Department of Physiology, University of Kentucky Medical Center, Lexington, KY, USA; Department of Anesthesiology and Perioperative Medicine, Pittsburgh Center for Pain Research and the Pittsburgh Project to end Opioid Misuse, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: BKT@pitt.edu.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoxalines › 6-Cyano-7-nitroquinoxaline-2,3-dion e › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Eucaryotes › Animaux › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Arginine › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Inhibiteurs des canaux calciques › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras monoinsaturés › Capsaïcine › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Cyclic Nucleotide-Regulated Protein Kinases › Cyclic AMP-Dependent Protein Kinases › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents des acides aminés excitateurs › Antagonistes des acides aminés excitateurs › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles somatosensoriels › Hyperalgésie › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Cellules › Neurones › Interneurones › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Anilides › Acétanilides › Lidocaïne › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Techniques d'investigation › Microscopie confocale › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Neuropeptide Y › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception de la douleur › Nociception › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Lésions des nerfs périphériques › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules de la corne dorsale › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du potassium › Chlorure de potassium › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des protéines › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs ionotropes du glutamate › Récepteurs du N-méthyl-D-aspartate › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteur neuropeptide Y › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents du système nerveux périphérique › Agents du système nerveux sensoriel › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Racines des nerfs spinaux › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Bloqueurs de canaux sodiques › Bloqueurs de canaux sodiques voltage-dépendants › Neuropeptide Y release in the rat spinal cord...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de mollusque › Conotoxines › Conotoxines-oméga › Neuropeptide Y release in the rat spinal cord...