Synthesis of new indazole based dual inhibitors of α-glucosidase and α-amylase enzymes, their in vitro, in silico and kinetics studies.

Computer Simulation Enzyme Inhibitors / chemical synthesis Glycoside Hydrolase Inhibitors / chemical synthesis In Vitro Techniques Indazoles / chemistry Kinetics Magnetic Resonance Spectroscopy Molecular Docking Simulation Molecular Structure Structure-Activity Relationship alpha-Amylases / antagonists & inhibitors
Carbothioamide Hyperglycemia Indazole α-amylase α-glucosidase

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
01 2020
Historique:
received: 02 04 2019
revised: 01 07 2019
accepted: 11 08 2019
pubmed: 28 8 2019
medline: 20 2 2021
entrez: 28 8 2019
Statut: ppublish

Résumé

The current study describes the discovery of novel inhibitors of α-glucosidase and α-amylase enzymes. For that purpose, new hybrid analogs of N-hydrazinecarbothioamide substituted indazoles 4-18 were synthesized and fully characterized by EI-MS, FAB-MS, HRFAB-MS,

Identifiants

DOI: 10.1016/j.bioorg.2019.103195 PMID: 31451297
pubmed: 31451297
pii: S0045-2068(19)30513-9
doi: 10.1016/j.bioorg.2019.103195
pii:
doi:

Substances chimiques

Enzyme Inhibitors 0
Glycoside Hydrolase Inhibitors 0
Indazoles 0
alpha-Amylases EC 3.2.1.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103195

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Rafaila Rafique (R)

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Khalid Mohammed Khan (KM)

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia. Electronic address: khalid.khan@iccs.edu.
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Sridevi Chigurupati (S)

Department of Pharmacology, Faculty of Pharmacy, Qassim University, Buraidah 52571, Saudi Arabia.

Abdul Wadood (A)

Department of Biochemistry, Shankar Campus, Abdul Wali Khan University, Mardan, Khyber Pukhtoonkhwa, Pakistan.

Ashfaq Ur Rehman (AU)

Department of Biochemistry, Shankar Campus, Abdul Wali Khan University, Mardan, Khyber Pukhtoonkhwa, Pakistan.

Arunkumar Karunanidhi (A)

Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Shehryar Hameed (S)

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Muhammad Taha (M)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia.

Mariya Al-Rashida (M)

Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Synthesis of new indazole based dual...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Synthesis of new indazole based dual...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › Synthesis of new indazole based dual...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Synthesis of new indazole based dual...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indazoles › Synthesis of new indazole based dual...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Synthesis of new indazole based dual...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Synthesis of new indazole based dual...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis of new indazole based dual...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Synthesis of new indazole based dual...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis of new indazole based dual...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Amylases › alpha-Amylases › Synthesis of new indazole based dual...