Engineering the metabolic pathways of lipid biosynthesis to develop robust microalgal strains for biodiesel production.
biodiesel
enhanced lipid productivity
lipid biosynthesis
metabolic engineering
robustness
Journal
Biotechnology and applied biochemistry
ISSN: 1470-8744
Titre abrégé: Biotechnol Appl Biochem
Pays: United States
ID NLM: 8609465
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
23
07
2019
accepted:
03
09
2019
pubmed:
6
9
2019
medline:
15
12
2020
entrez:
6
9
2019
Statut:
ppublish
Résumé
Algal lipids have shown promising feedstock to produce biodiesel due to higher energy content, higher cetane number, and renewable nature. However, at present, the lipid productivity is too low to meet the commercial needs. Various approaches can be employed to enhance the lipid content and lipid productivity in microalgae. Stress manipulation is an attractive option to modify the algal lipid content, but it faces the drawback of time-consuming production processing and lack of information about molecular mechanisms related to triacylglycerides production in response to stress. Developing the robust hyper lipid accumulating algal strains has gained momentum due to advances in metabolic engineering and synthetic biology tools. Understanding the molecular basis of lipid biosynthesis followed by reorienting the related pathways through genomic modification is an alluring strategy that is believed to achieve the industrial and economic robustness. This review portrays the use of integrated OMIC approaches to elucidate the molecular mechanisms of strain adaptability in response to stress conditions, and identification of molecular pathways that should become novel targets to develop novel algal strains. Moreover, an update on the metabolic engineering approaches to improve the lipid production in microalgae is also provided.
Substances chimiques
Biofuels
0
Lipids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-51Subventions
Organisme : Higher Education Commission, Pakistan
ID : 7300/Punjab/NRPU/R&D/HEC/2017
Organisme : 1000 Talent Plan of Sichuan, China
Informations de copyright
© 2019 International Union of Biochemistry and Molecular Biology, Inc.
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