Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas.

Anaplastic Lymphoma Kinase / genetics Brain Neoplasms / classification DNA Methylation Epigenomics / methods Female Gene Expression Regulation, Neoplastic Glioma / classification Humans Infant Infant, Newborn Male Protein-Tyrosine Kinases / genetics Proto-Oncogene Proteins / genetics Proto-Oncogene Proteins c-met / genetics Receptor Protein-Tyrosine Kinases / genetics Receptor, trkA / genetics Survival Analysis Exome Sequencing / methods

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
25 09 2019
Historique:
received: 18 01 2019
accepted: 13 08 2019
entrez: 27 9 2019
pubmed: 27 9 2019
medline: 14 1 2020
Statut: epublish

Résumé

Infant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors have a higher mortality rate, while high-grade tumors have a better outcome. However, we have little understanding of their biology and therefore cannot explain this behavior nor what constitutes optimal clinical management. Here we report a comprehensive genetic analysis of an international cohort of clinically annotated infant gliomas, revealing 3 clinical subgroups. Group 1 tumors arise in the cerebral hemispheres and harbor alterations in the receptor tyrosine kinases ALK, ROS1, NTRK and MET. These are typically single-events and confer an intermediate outcome. Groups 2 and 3 gliomas harbor RAS/MAPK pathway mutations and arise in the hemispheres and midline, respectively. Group 2 tumors have excellent long-term survival, while group 3 tumors progress rapidly and do not respond well to chemoradiation. We conclude that infant gliomas comprise 3 subgroups, justifying the need for specialized therapeutic strategies.

Identifiants

DOI: 10.1038/s41467-019-12187-5 PMID: 31554817 PMC: PMC6761184
pubmed: 31554817
doi: 10.1038/s41467-019-12187-5
pii: 10.1038/s41467-019-12187-5
pmc: PMC6761184
doi:

Substances chimiques

Proto-Oncogene Proteins 0
Anaplastic Lymphoma Kinase EC 2.7.10.1
MET protein, human EC 2.7.10.1
Protein-Tyrosine Kinases EC 2.7.10.1
Proto-Oncogene Proteins c-met EC 2.7.10.1
ROS1 protein, human EC 2.7.10.1
Receptor Protein-Tyrosine Kinases EC 2.7.10.1
Receptor, trkA EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4343

Subventions

Organisme : Canadian Cancer Society Research Institute (Société Canadienne du Cancer)
ID : 702296
Pays : International
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)
ID : 159805
Pays : International

Références

Pediatr Blood Cancer. 2014 Jul;61(7):1173-9
pubmed: 24482038
Sci Rep. 2016 Feb 10;6:21597
pubmed: 26862001
Cancer Cell. 2017 Oct 9;32(4):520-537.e5
pubmed: 28966033
J Clin Oncol. 2017 Apr 20;35(12):1320-1327
pubmed: 28414926
N Engl J Med. 2018 Feb 22;378(8):731-739
pubmed: 29466156
Nucleic Acids Res. 2013 Apr;41(7):e90
pubmed: 23476028
Genes Dev. 2007 Feb 15;21(4):379-84
pubmed: 17299132
Lancet Oncol. 2013 May;14(6):472-80
pubmed: 23598171
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
J Neurosurg Pediatr. 2017 Jul;20(1):51-55
pubmed: 28387643
Acta Neuropathol. 2016 Jun;131(6):803-20
pubmed: 27157931
Nat Med. 2012 Feb 12;18(3):378-81
pubmed: 22327623
Cancer Discov. 2017 Apr;7(4):400-409
pubmed: 28183697
Cancer Res. 2008 Nov 1;68(21):8673-7
pubmed: 18974108
Lancet Oncol. 2018 May;19(5):705-714
pubmed: 29606586
Neuro Oncol. 2017 Aug 1;19(8):1135-1144
pubmed: 28339824
Bioinformatics. 2014 May 15;30(10):1363-9
pubmed: 24478339
Nat Med. 2013 Nov;19(11):1469-1472
pubmed: 24162815
Pediatr Blood Cancer. 2016 Nov;63(11):2038-41
pubmed: 27398937
Nat Genet. 2014 May;46(5):444-450
pubmed: 24705251
Neuro Oncol. 2016 Oct 1;18(suppl_5):v1-v75
pubmed: 28475809
Br J Cancer. 2018 Sep;119(6):693-696
pubmed: 30220707
Nature. 2005 Aug 4;436(7051):720-4
pubmed: 16079850
Lancet Neurol. 2003 Jul;2(7):395-403
pubmed: 12849117
Neuro Oncol. 2012 Jun;14(6):777-89
pubmed: 22492957
J Neurooncol. 1996 May-Jun;28(2-3):245-56
pubmed: 8832466
N Engl J Med. 1996 Jun 6;334(23):1505-11
pubmed: 8618605
Bioinformatics. 2013 Aug 15;29(16):2041-3
pubmed: 23736529
Pediatr Blood Cancer. 2010 Apr;54(4):573-8
pubmed: 20049932
Bioinformatics. 2011 Jul 15;27(14):1922-8
pubmed: 21593131
N Engl J Med. 2015 Jun 25;372(26):2499-508
pubmed: 26061753
Cancer. 2016 Apr 15;122(8):1261-9
pubmed: 26970559
Nat Genet. 2012 Jan 29;44(3):251-3
pubmed: 22286216
BMJ Case Rep. 2016 Aug 16;2016:
pubmed: 27530886
Bioinformatics. 2016 Apr 15;32(8):1220-2
pubmed: 26647377
Neuro Oncol. 2015 Oct;17(10):1365-73
pubmed: 25795305
J Clin Oncol. 2015 Mar 20;33(9):1015-22
pubmed: 25667294
Nat Cell Biol. 2007 May;9(5):493-505
pubmed: 17450133
J Clin Oncol. 2017 Sep 1;35(25):2934-2941
pubmed: 28727518
Oncotarget. 2017 Jan 10;8(2):2104-2113
pubmed: 27791984
J Neuropathol Exp Neurol. 2017 Jul 1;76(7):562-570
pubmed: 28863456
World J Surg. 2013 Feb;37(2):459-65
pubmed: 23135423
Cancer Res. 2001 Jul 1;61(13):4956-60
pubmed: 11431323
Genome Biol. 2011 Aug 11;12(8):R72
pubmed: 21835007
Neuro Oncol. 2015 Jan;16 Suppl 10:x1-x36
pubmed: 25542864
Pediatr Blood Cancer. 2014 Mar;61(3):457-63
pubmed: 24039013
Clin Cancer Res. 2011 Jul 15;17(14):4790-8
pubmed: 21610142
J Clin Oncol. 2012 Jul 20;30(21):2641-7
pubmed: 22665535
J Natl Cancer Inst. 2017 Dec 1;109(12):
pubmed: 29370427
Nature. 2012 Jan 29;482(7384):226-31
pubmed: 22286061
Int J Cancer. 2003 May 20;105(1):88-91
pubmed: 12672035
Cancer Cell. 2006 Dec;10(6):459-72
pubmed: 17157787
Eur J Cancer. 2017 Aug;81:206-225
pubmed: 28649001
Neuro Oncol. 2017 Feb 1;19(2):153-161
pubmed: 27282398
PLoS Comput Biol. 2011 May;7(5):e1001138
pubmed: 21625565

Auteurs

Ana S Guerreiro Stucklin (AS)

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
ORCID: 0000-0003-3136-9241

Scott Ryall (S)

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Kohei Fukuoka (K)

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.

Michal Zapotocky (M)

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

Alvaro Lassaletta (A)

Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Pediatric Hematology and Oncology, Hospital Universitario Niño Jesús, Madrid, Spain.

Christopher Li (C)

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Taylor Bridge (T)

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

Byungjin Kim (B)

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Anthony Arnoldo (A)

Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

Paul E Kowalski (PE)

Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

Yvonne Zhong (Y)

Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

Monique Johnson (M)

Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

Claire Li (C)

Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
ORCID: 0000-0001-9326-9583

Arun K Ramani (AK)

Centre for Computational Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

Robert Siddaway (R)

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

Liana Figueiredo Nobre (LF)

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.

Pasqualino de Antonellis (P)

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

Christopher Dunham (C)

Division of Anatomic Pathology, British Columbia Children's Hospital, Vancouver, BC, Canada.
Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada.

Sylvia Cheng (S)

Department of Pediatrics, The University of British Columbia, Vancouver, BC, Canada.
Division of Hematology/Oncology/BMT, British Columbia Children's Hospital, Vancouver, BC, Canada.

Daniel R Boué (DR)

Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Department of Pathology, The Ohio State University College of Medicine, Columbus, OH, USA.

Jonathan L Finlay (JL)

Division of Hematology/Oncology/Bone Marrow Transplantation, Nationwide Children's Hospital, Columbus, OH, USA.

Scott L Coven (SL)

Division of Hematology/Oncology/Bone Marrow Transplantation, Nationwide Children's Hospital, Columbus, OH, USA.

Inmaculada de Prada (I)

Department of Pathology, Hospital Universitario Niño Jesús, Madrid, Spain.

Marta Perez-Somarriba (M)

Department of Pediatric Hematology and Oncology, Hospital Universitario Niño Jesús, Madrid, Spain.

Claudia C Faria (CC)

Division of Neurosurgery, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal.
Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

Michael A Grotzer (MA)

Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.

Elisabeth Rushing (E)

Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland.

David Sumerauer (D)

Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

Josef Zamecnik (J)

Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

Lenka Krskova (L)

Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

Miguel Garcia Ariza (M)

Department of Pediatric Oncology, Hospital Cruces, Bilbao, Spain.

Ofelia Cruz (O)

Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.

Andres Morales La Madrid (A)

Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.

Palma Solano (P)

Department of Pediatric Oncology, Hospital Infantil Virgen del Rocio, Sevilla, Spain.

Keita Terashima (K)

Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.

Yoshiko Nakano (Y)

Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.
ORCID: 0000-0001-5394-8194

Koichi Ichimura (K)

Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.
ORCID: 0000-0002-3851-2349

Motoo Nagane (M)

Department of Neurosurgery, Kyorin University Faculty of Medicine, Tokyo, Japan.
ORCID: 0000-0002-0018-1652

Hiroaki Sakamoto (H)

Department of Pediatric Neurosurgery, Osaka City General Hospital, Osaka, Japan.

Maria Joao Gil-da-Costa (MJ)

Division of Pediatric Hematoncology, University Hospital de São João, Porto, Portugal.

Roberto Silva (R)

Department of Pathology, University Hospital de São João, Porto, Portugal.

Donna L Johnston (DL)

Division of Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.

Jean Michaud (J)

Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON, Canada.

Bev Wilson (B)

Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.

Frank K H van Landeghem (FKH)

Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.

Angelica Oviedo (A)

Department of Anatomic Pathology, Dalhousie University, Halifax, NS, Canada.
Department of Pathology Laboratory Medicine, IWK Health Centre, Halifax, NS, Canada.

P Daniel McNeely (PD)

Division of Neurosurgery, IWK Health Centre, Halifax, NS, Canada.

Bruce Crooks (B)

Division of Hematology-Oncology, IWK Health Centre, Halifax, NS, Canada.

Iris Fried (I)

The Department of Pediatric Hematology Oncology, Hadassah Medical Center, Jerusalem, Israel.

Nataliya Zhukova (N)

Children's Cancer Centre, Royal Children's Hospital, Melbourne, Australia.

Jordan R Hansford (JR)

Children's Cancer Centre, Royal Children's Hospital, Melbourne, Australia.
Murdoch Children's Research Institute, Department of Paediatrics, University of Melbourne, Melbourne, Australia.
ORCID: 0000-0001-7733-383X

Amulya Nageswararao (A)

Division of Pediatric Hematology/Oncology, Mayo Clinic, Rochester, MN, USA.

Livia Garzia (L)

Department of Medicine, McGill University, Montreal, QC, Canada.

Mary Shago (M)

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

Michael Brudno (M)

Centre for Computational Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

Meredith S Irwin (MS)

Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.

Ute Bartels (U)

Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.

Vijay Ramaswamy (V)

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
ORCID: 0000-0002-6557-895X

Eric Bouffet (E)

Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.

Michael D Taylor (MD)

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Department of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.

Uri Tabori (U)

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

Cynthia Hawkins (C)

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada. cynthia.hawkins@sickkids.ca.
The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON, Canada. cynthia.hawkins@sickkids.ca.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. cynthia.hawkins@sickkids.ca.
Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada. cynthia.hawkins@sickkids.ca.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs à activité tyrosine kinase › Kinase du lymphome anaplasique › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-met › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs à activité tyrosine kinase › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs facteur croissance nerf › Récepteur trkA › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Alterations in ALK/ROS1/NTRK/MET drive a group...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Séquençage de l'exome › Alterations in ALK/ROS1/NTRK/MET drive a group...