New HIV-1 circulating recombinant form 94: from phylogenetic detection of a large transmission cluster to prevention in the age of geosocial-networking apps in France, 2013 to 2017.
Adult
Cluster Analysis
DNA, Viral
/ genetics
Disease Outbreaks
/ prevention & control
Drug Resistance, Viral
/ genetics
France
/ epidemiology
HIV Infections
/ epidemiology
HIV-1
/ classification
Humans
Male
Online Social Networking
Phylogeny
Phylogeography
Recombination, Genetic
Reverse Transcriptase Polymerase Chain Reaction
Sequence Alignment
Sexual and Gender Minorities
/ statistics & numerical data
Viral Load
Viremia
/ virology
Virulence
Whole Genome Sequencing
HIV CRF94
HIV Outbreak
HIV Prevention
HIV cluster
phylogenetic analysis
Journal
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
ISSN: 1560-7917
Titre abrégé: Euro Surveill
Pays: Sweden
ID NLM: 100887452
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
entrez:
3
10
2019
pubmed:
3
10
2019
medline:
1
9
2020
Statut:
ppublish
Résumé
BackgroundEnding the HIV pandemic must involve new tools to rapidly identify and control local outbreaks and prevent the emergence of recombinant strains with epidemiological advantages.AimThis observational study aimed to investigate in France a cluster of HIV-1 cases related to a new circulating recombinant form (CRF). The confirmation this CRF's novelty as well as measures to control its spread are presented.MethodsPhylogenetic analyses of HIV sequences routinely generated for drug resistance genotyping before 2018 in French laboratories were employed to detect the transmission chain. The CRF involved was characterised by almost full-length viral sequencing for six cases. Cases' clinical data were reviewed. Where possible, epidemiological information was collected with a questionnaire.ResultsThe transmission cluster comprised 49 cases, mostly diagnosed in 2016-2017 (n = 37). All were infected with a new CRF, CRF94_cpx. The molecular proximity of this CRF to X4 strains and the high median viraemia, exceeding 5.0 log
Identifiants
pubmed: 31576801
doi: 10.2807/1560-7917.ES.2019.24.39.1800658
pmc: PMC6774227
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
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