Genotypic characterisation of monepantel resistance in historical and newly derived field strains of Teladorsagia circumcincta.
Aminoacetonitrile
/ analogs & derivatives
Animals
Anthelmintics
/ pharmacology
DNA, Helminth
/ chemistry
Drug Resistance
/ genetics
Genotype
High-Throughput Nucleotide Sequencing
/ veterinary
Loss of Function Mutation
/ physiology
Male
Microsatellite Repeats
Scotland
Sequence Alignment
Sheep
Sheep Diseases
/ drug therapy
Trichostrongyloidea
/ classification
Trichostrongyloidiasis
/ drug therapy
United Kingdom
Anthelmintic resistance
MPTL-1 gene
Microsatellite
Monepantel
Teladorsagia circumcincta
Journal
International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
Titre abrégé: Int J Parasitol Drugs Drug Resist
Pays: Netherlands
ID NLM: 101576715
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
26
07
2019
revised:
02
10
2019
accepted:
04
10
2019
pubmed:
18
10
2019
medline:
15
5
2020
entrez:
18
10
2019
Statut:
ppublish
Résumé
Recent reports of monepantel (MPTL) resistance in UK field isolates of Teladorsagia circumcincta has highlighted the need for a better understanding of the mechanism of MPTL-resistance in order to preserve its anthelmintic efficacy in this economically important species. Nine discrete populations of T. circumcincta were genotypically characterised; three MPTL-susceptible isolates, three experimentally selected MPTL-resistant strains and three field derived populations. Full-length Tci-mptl-1 gene sequences were generated and comparisons between the MPTL-susceptible isolates, MPTL-resistant strains and one field isolate, showed that different putative MPTL-resistance conferring mutations were present in different resistant isolates. Truncated forms of the Tci-mptl-1 gene were also observed. The genetic variability of individual larvae, within and between populations, was examined using microsatellite analyses at 10 'neutral' loci (presumed to be unaffected by MPTL). Results confirmed that there was little background genetic variation between the populations, global F
Identifiants
pubmed: 31622822
pii: S2211-3207(19)30106-X
doi: 10.1016/j.ijpddr.2019.10.002
pmc: PMC6796645
pii:
doi:
Substances chimiques
Anthelmintics
0
DNA, Helminth
0
Aminoacetonitrile
3739OQ10IJ
monepantel
82MA79VJ33
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-69Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M003949
Pays : United Kingdom
Informations de copyright
Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.
Références
Vet Parasitol. 2016 Sep 15;228:193-196
pubmed: 27692326
Vet Rec. 2007 Oct 13;161(15):535-6
pubmed: 17938416
Int J Parasitol Drugs Drug Resist. 2015 Feb 07;5(1):9-15
pubmed: 25941625
Vet Parasitol Reg Stud Reports. 2018 Jan;11:12-14
pubmed: 31014610
Int J Parasitol. 2007 Mar;37(3-4):435-47
pubmed: 17234192
Mol Pharmacol. 2015 Jan;87(1):96-102
pubmed: 25352042
Bioinformatics. 2012 Oct 1;28(19):2537-9
pubmed: 22820204
Int J Parasitol Drugs Drug Resist. 2012 Mar 03;2:92-7
pubmed: 24533269
Mol Biochem Parasitol. 2002 Apr 9;120(2):297-300
pubmed: 11897135
PLoS Negl Trop Dis. 2015 Feb 06;9(2):e0003494
pubmed: 25658086
Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):236-240
pubmed: 28501715
PLoS Pathog. 2013;9(8):e1003524
pubmed: 23950710
Mol Biochem Parasitol. 1994 Feb;63(2):299-303
pubmed: 7911975
Vet Parasitol. 2018 Jun 15;257:48-53
pubmed: 29907192
Parasit Vectors. 2016 Sep 29;9(1):522
pubmed: 27682865
Genetics. 1978 Jul;89(3):583-90
pubmed: 17248844
Int J Parasitol. 2008 Jan;38(1):111-22
pubmed: 17727857
Parasite Immunol. 2009 May;31(5):274-82
pubmed: 19388948
Int J Parasitol. 2010 Sep;40(11):1247-55
pubmed: 20451524
Biol Direct. 2008 May 21;3:20
pubmed: 18495041
Life Sci. 2006 Nov 25;79(26):2413-31
pubmed: 16979192
PLoS Pathog. 2009 Apr;5(4):e1000380
pubmed: 19360096
Int J Parasitol. 2008 Jul;38(8-9):885-900
pubmed: 18068173
Parasitol Res. 2010 Jan;106(2):529-32
pubmed: 19795134
Nature. 2008 Mar 13;452(7184):176-80
pubmed: 18337814
Vet Parasitol. 2007 Mar 31;144(3-4):313-20
pubmed: 17101226
Vet Parasitol. 2019;276S:100003
pubmed: 34311939
Vet Parasitol. 2013 Nov 15;198(1-2):166-71
pubmed: 23953148
Biochem Pharmacol. 1984 Oct 1;33(19):3037-40
pubmed: 6487354
Vet Parasitol. 2015 Apr 30;209(3-4):278-80
pubmed: 25770852
Int J Parasitol. 1988 Nov;18(7):885-936
pubmed: 3066771
Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):199-206
pubmed: 27760394
Int J Parasitol Drugs Drug Resist. 2015 May 15;5(2):69-76
pubmed: 26042197
Mol Ecol. 2009 Dec;18(24):5086-100
pubmed: 19900171
Mol Biol Evol. 2007 Mar;24(3):621-31
pubmed: 17150975
Exp Parasitol. 2000 Aug;95(4):271-6
pubmed: 11038310
Int J Parasitol Drugs Drug Resist. 2012 Feb 12;2:20-8
pubmed: 24533268
Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):70-80
pubmed: 29414109
Mol Ecol Resour. 2010 May;10(3):564-7
pubmed: 21565059
Vet Parasitol. 2012 Oct 26;189(2-4):299-307
pubmed: 22560313
Mol Biochem Parasitol. 2008 May;159(1):59-63
pubmed: 18295911
Mol Biochem Parasitol. 2006 Aug;148(2):181-9
pubmed: 16687182
PLoS Genet. 2017 Jun 23;13(6):e1006857
pubmed: 28644839
Vet Parasitol. 2004 Sep 2;123(3-4):189-99
pubmed: 15325045
Vet Parasitol. 2016 Jan 30;216:4-6
pubmed: 26801587
Vet Rec. 2001 Dec 22-29;149(25):778-9
pubmed: 11808671
Vet Parasitol. 2005 Dec 10;134(3-4):261-6
pubmed: 16168563
Vet Parasitol. 2016 Apr 15;220:77-82
pubmed: 26995725
Vet Parasitol. 1999 Jan 14;80(3):231-7
pubmed: 9950346
Vet Rec. 2005 Jan 22;156(4):105-9
pubmed: 15704550
Parasit Vectors. 2014 Dec 17;7:598
pubmed: 25515711
Int J Parasitol. 1990 Jul;20(4):515-23
pubmed: 2210945
Trends Parasitol. 2004 Oct;20(10):477-81
pubmed: 15363441
Pharmacogenet Genomics. 2008 Feb;18(2):129-40
pubmed: 18192899