Synthesis of Novel Triazinoindole-Based Thiourea Hybrid: A Study on α-Glucosidase Inhibitors and Their Molecular Docking.

Glycoside Hydrolase Inhibitors / chemical synthesis Molecular Docking Simulation Structure-Activity Relationship Thiourea / analogs & derivatives alpha-Glucosidases / chemistry
SAR alpha-glucosidase molecular docking study synthesis thiosemicarbazide triazinoindole

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
23 Oct 2019
Historique:
received: 12 09 2019
revised: 17 10 2019
accepted: 21 10 2019
entrez: 27 10 2019
pubmed: 28 10 2019
medline: 7 3 2020
Statut: epublish

Résumé

A new class of triazinoindole-bearing thiosemicarbazides (

Identifiants

DOI: 10.3390/molecules24213819 PMID: 31652777 PMC: PMC6864627
pubmed: 31652777
pii: molecules24213819
doi: 10.3390/molecules24213819
pmc: PMC6864627
pii:
doi:

Substances chimiques

Glycoside Hydrolase Inhibitors 0
alpha-Glucosidases EC 3.2.1.20
Thiourea GYV9AM2QAG

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Higher Education Commision, Pakistan
ID : 5721 & 5092.
Organisme : Higher Education Commision, Pakistan
ID : 5721 & 5092.

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest.

Références

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Auteurs

Muhammad Taha (M)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia. mtaha@iau.edu.sa.

Foziah J Alshamrani (FJ)

Neurology Department, King Fahad hospital of University, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 34211, Saudi Arabia. Fshamrani@uod.edu.sa.
Department of Neuroscience Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia. Fshamrani@uod.edu.sa.

Fazal Rahim (F)

Department of Chemistry, Hazara University, Mansehra-21300, Khyber Pakhtunkhwa, Pakistan. fazalstar@gmail.com.

Shawkat Hayat (S)

Department of Chemistry, Hazara University, Mansehra-21300, Khyber Pakhtunkhwa, Pakistan. shawkathayat866@yahoo.com.

Hayat Ullah (H)

Department of Chemistry, Hazara University, Mansehra-21300, Khyber Pakhtunkhwa, Pakistan. ayaanwazir366@gmail.com.

Khalid Zaman (K)

Department of Chemistry, Hazara University, Mansehra-21300, Khyber Pakhtunkhwa, Pakistan. khalidchemist69@yahoo.com.

Syahrul Imran (S)

Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor D.E., Malaysia. imran@isiswa.uitm.edu.my.
Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam 40450, Selangor D.E., Malaysia. imran@isiswa.uitm.edu.my.

Khalid Mohammed Khan (KM)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. khalid.khan@iccs.edu.

Farzana Naz (F)

Department of Chemistry, Jinnah University for Women, 5-C, Nazimabad, Karachi-74600, Pakistan. farzanahej@yahoo.com.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › Synthesis of Novel Triazinoindole-Based...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis of Novel Triazinoindole-Based...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis of Novel Triazinoindole-Based...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiourée › Synthesis of Novel Triazinoindole-Based...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › alpha-Glucosidase › Synthesis of Novel Triazinoindole-Based...