Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer.
Adult
Antigens, Neoplasm
Cohort Studies
Cross-Sectional Studies
DNA, Neoplasm
/ metabolism
Duodenal Ulcer
/ epidemiology
Female
GPI-Linked Proteins
/ genetics
Gene Expression Regulation, Neoplastic
Genetic Markers
Genetic Predisposition to Disease
Genotype
Helicobacter Infections
/ complications
Helicobacter pylori
Humans
Immunoglobulin G
/ blood
Japan
/ epidemiology
Male
Middle Aged
Neoplasm Proteins
/ genetics
Polymorphism, Single Nucleotide
/ genetics
Risk Factors
Japan
PSCA
cross-sectional study
duodenal ulcer
Journal
Journal of epidemiology
ISSN: 1349-9092
Titre abrégé: J Epidemiol
Pays: Japan
ID NLM: 9607688
Informations de publication
Date de publication:
05 Jan 2021
05 Jan 2021
Historique:
pubmed:
17
12
2019
medline:
6
5
2021
entrez:
17
12
2019
Statut:
ppublish
Résumé
While duodenal ulcer (DU) and gastric cancer (GC) are both H. pylori infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in PSCA and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population. Six PSCA SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between the SNPs and risk of DU/GU. PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18-1.51; P = 2.28 × 10 Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.
Sections du résumé
BACKGROUND
BACKGROUND
While duodenal ulcer (DU) and gastric cancer (GC) are both H. pylori infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in PSCA and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population.
METHODS
METHODS
Six PSCA SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between the SNPs and risk of DU/GU.
RESULTS
RESULTS
PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18-1.51; P = 2.28 × 10
CONCLUSIONS
CONCLUSIONS
Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.
Identifiants
pubmed: 31839644
doi: 10.2188/jea.JE20190184
pmc: PMC7738644
doi:
Substances chimiques
Antigens, Neoplasm
0
DNA, Neoplasm
0
GPI-Linked Proteins
0
Genetic Markers
0
Immunoglobulin G
0
Neoplasm Proteins
0
PSCA protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12-20Références
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