Whole transcriptome sequencing reveals that non-coding RNAs are related to embryo morphogenesis and development in rabbits.

Animals Embryo, Mammalian / metabolism Embryonic Development / genetics Gene Regulatory Networks Morphogenesis RNA, Circular / metabolism RNA, Long Noncoding / metabolism RNA, Messenger / metabolism RNA-Seq Rabbits / embryology Exome Sequencing
Embryo morphogenesis Embryonic development RNA-Seq Rabbit circRNAs lncRNAs

Journal

Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135

Informations de publication

Date de publication:
05 2020
Historique:
received: 15 08 2019
revised: 07 11 2019
accepted: 19 12 2019
pubmed: 28 12 2019
medline: 7 4 2021
entrez: 28 12 2019
Statut: ppublish

Résumé

The roles of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in embryonic development remain unclear. We performed a comprehensive analysis of lncRNA and circRNA profiles in rabbit embryos at different stages by whole transcriptome sequencing. We identified 719 lncRNAs and 744 circRNAs that were differentially expressed between stages S1, S2 and S3. A total of 241 differentially expressed lncRNAs and 166 differentially expressed circRNAs were significantly involved in embryonic morphogenesis and development. An RNA network was established and of the embryonic development-associated RNAs, the lncRNAs TCONS_00009253 and TCONS_00010436 were persistently downregulated, while circRNA_07129, circRNA_15209, and circRNA_12526 were persistently upregulated, and their co-expressed mRNAs TBX1, WNT3 and FGFR2 were persistently downregulated during embryonic development. These candidate RNAs were mainly involved in the Wnt, PI3K-Akt, and calcium signaling pathways. This study reports candidate lncRNAs and circRNAs that may be indispensable for the morphogenesis and development of rabbit embryos.

Identifiants

DOI: 10.1016/j.ygeno.2019.12.016 PMID: 31881265
pubmed: 31881265
pii: S0888-7543(19)30551-8
doi: 10.1016/j.ygeno.2019.12.016
pii:
doi:

Substances chimiques

RNA, Circular 0
RNA, Long Noncoding 0
RNA, Messenger 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2203-2212

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflicts of interest.

Auteurs

Liangde Kuang (L)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Min Lei (M)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Congyan Li (C)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Zhiqiang Guo (Z)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Yongjun Ren (Y)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Xiangyu Zhang (X)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Jie Zheng (J)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Cuixia Zhang (C)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Chao Yang (C)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Xiuli Mei (X)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Li Tang (L)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Yang Ji (Y)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Xiaodong Deng (X)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Rui Yang (R)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China.

Xiaohong Xie (X)

Sichuan Animal Sciences Academy, NO. 7 Niusha Road, Chengdu, Sichuan 610066, China; Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China. Electronic address: swin258@163.com.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Whole transcriptome sequencing reveals that...
questionsmedicales.fr › Structures de l'embryon › Embryon de mammifère › Whole transcriptome sequencing reveals that...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Whole transcriptome sequencing reveals that...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › Whole transcriptome sequencing reveals that...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Whole transcriptome sequencing reveals that...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN circulaire › Whole transcriptome sequencing reveals that...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › Whole transcriptome sequencing reveals that...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Whole transcriptome sequencing reveals that...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › RNA-Seq › Whole transcriptome sequencing reveals that...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › Whole transcriptome sequencing reveals that...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Séquençage de l'exome › Whole transcriptome sequencing reveals that...