Synthesis, α-glycosidase inhibitory potential and molecular docking study of benzimidazole derivatives.

Benzimidazoles / pharmacology Glycoside Hydrolase Inhibitors / chemical synthesis Glycoside Hydrolases / antagonists & inhibitors Molecular Docking Simulation Molecular Structure
Benzimidazole Molecular docking Oxadiazole Synthesis α-glycosidase inhibition

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
01 2020
Historique:
received: 11 02 2019
revised: 22 12 2019
accepted: 24 12 2019
pubmed: 9 1 2020
medline: 9 3 2021
entrez: 9 1 2020
Statut: ppublish

Résumé

A series of twenty-six analogs of benzimidazole based oxadiazole have been synthesized and evaluated against alpha-glycosidase enzyme. Most the analogs showed excellent to good inhibitory potential. Among the screened analogs, analog 1, 2, 3 and 14 with IC

Identifiants

DOI: 10.1016/j.bioorg.2019.103555 PMID: 31911306
pubmed: 31911306
pii: S0045-2068(19)30226-3
doi: 10.1016/j.bioorg.2019.103555
pii:
doi:

Substances chimiques

Benzimidazoles 0
Glycoside Hydrolase Inhibitors 0
Glycoside Hydrolases EC 3.2.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103555

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Muhammad Taha (M)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia. Electronic address: mtaha@iau.edu.sa.

Fazal Rahim (F)

Depatment of Chemistry, Hazara University, Mansehra 21300, Khyber Pakhtunkhwa, Pakistan.

Khalid Zaman (K)

Depatment of Chemistry, Hazara University, Mansehra 21300, Khyber Pakhtunkhwa, Pakistan.

Manikandan Selvaraj (M)

Monash University School of Chemical Engineering, Bandar Sunway 47500 Selangor Darul Ehsan, Malaysia.

Nizam Uddin (N)

Department of Chemistry, University of Karachi, Karachi 75270, Pakistan.

Rai Khalid Farooq (RK)

Department of Neuroscience Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

Muhammad Nawaz (M)

Department of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.

Muhammad Sajid (M)

Department of Biochemistry, Hazara University, Mansehra 21300, Khyber Pakhtunkhwa, Pakistan.

Faisal Nawaz (F)

Department of Chemistry, University of Wah, Quaid Avenue, Wah Cantt 47000, Pakistan.

Mohamad Ibrahim (M)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia.

Khalid Mohammed Khan (KM)

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzimidazoles › Synthesis, α-glycosidase inhibitory potential...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › Synthesis, α-glycosidase inhibitory potential...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Synthesis, α-glycosidase inhibitory potential...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis, α-glycosidase inhibitory potential...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Synthesis, α-glycosidase inhibitory potential...