Catalytic activity and structural changes of catalase in the presence of Levothyroxine and Isoxsuprine hydrochloride.

Biocatalysis / drug effects Catalase / chemistry Isoxsuprine / adverse effects Molecular Docking Simulation Protein Binding Protein Conformation / drug effects Quantum Theory Thyroxine / adverse effects
Catalase Isoxsuprine hydrochloride Levothyroxine

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
01 Jun 2020
Historique:
received: 16 12 2019
revised: 05 02 2020
accepted: 07 02 2020
pubmed: 12 2 2020
medline: 2 2 2021
entrez: 12 2 2020
Statut: ppublish

Résumé

Two drugs that pregnant women (with hypothyroidism) may use during pregnancy include Isoxsuprine hydrochloride (ISO) and levothyroxine (LEV); ISO to reduce uterine contractions and LEV for the treatment of hypothyroidism. In the current work, we explored the mechanism of binding affinity between the above drugs and antioxidant enzyme Bovine Liver Catalase (BLC). The experimental results confirmed that both drugs could bind with BLC to form drug-BLC complexes but LEV showed a higher binding affinity toward enzyme. The binding constants of LEV-and ISO-BLC were 0.42 × 10

Identifiants

DOI: 10.1016/j.ijbiomac.2020.02.064 PMID: 32045611
pubmed: 32045611
pii: S0141-8130(19)40360-7
doi: 10.1016/j.ijbiomac.2020.02.064
pii:
doi:

Substances chimiques

Catalase EC 1.11.1.6
Thyroxine Q51BO43MG4
Isoxsuprine R15UI3245N

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

126-136

Informations de copyright

Copyright © 2020. Published by Elsevier B.V.

Auteurs

Somaye Shahraki (S)

Department of Chemistry, University of Zabol, Zabol, Iran. Electronic address: s-shahraki@uoz.ac.ir.

Hojat Samareh Delarami (HS)

Department of Chemistry, University of Zabol, Zabol, Iran.

Maryam Saeidifar (M)

Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Karaj, Iran.

Razieh Nejat (R)

Department of Chemistry, Kosar University of Bojnord, Bojnord, Iran.

Articles similaires

Decoding the genomic terrain: functional insights into 14 chemosensory proteins in whitefly Bemisia tabaci Asia II-1.

M N Rudra Gouda, Sabtharishi Subramanian
1.00
Animals Hemiptera Insect Proteins Phylogeny Insecticides

Conservation of the cooling agent binding pocket within the TRPM subfamily.

Kate Huffer, Matthew C S Denley, Elisabeth V Oskoui et al.
1.00
TRPM Cation Channels Animals Binding Sites Mice Pyrimidinones

Drug repurposing against fucosyltransferase-2 via docking, STD-NMR, and molecular dynamic simulation studies.

Muhammad Atif, Humaira Zafar, Atia-Tul- Wahab et al.
1.00
Fucosyltransferases Drug Repositioning Molecular Docking Simulation Molecular Dynamics Simulation Humans

A head-to-head comparison of MM/PBSA and MM/GBSA in predicting binding affinities for the CB

Mei Qian Yau, Clarence W Y Liew, Jing Hen Toh et al.
1.00
Receptor, Cannabinoid, CB1 Ligands Molecular Dynamics Simulation Protein Binding Thermodynamics

Classifications MeSH

questionsmedicales.fr › Métabolisme › Biocatalyse › Catalytic activity and structural changes of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Peroxidases › Catalase › Catalytic activity and structural changes of...
questionsmedicales.fr › Composés chimiques organiques › Amines › Éthylamines › Phénéthylamines › Isoxsuprine › Catalytic activity and structural changes of...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Catalytic activity and structural changes of...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Catalytic activity and structural changes of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Catalytic activity and structural changes of...
questionsmedicales.fr › Disciplines des sciences naturelles › Physique › Physique nucléaire › Théorie quantique › Catalytic activity and structural changes of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Acides aminés aromatiques › Thyroxine › Catalytic activity and structural changes of...